Results 11 to 20 of about 10,859,059 (267)
Natural product fragment combination to performance-diverse pseudo-natural products
Nature Communications, 2021 Natural product structure and fragment-based compound development inspire pseudo-natural product design through different combinations of a given natural product fragment set to compound classes expected to be chemically and biologically diverse.
Michael Grigalunas +12 more
semanticscholar +1 more source
BMC Bioinformatics, 2020 Background Despite continued efforts using chemical similarity methods in virtual screening, currently developed approaches suffer from time-consuming multistep procedures and low success rates.
Prasannavenkatesh Durai +3 more
doaj +1 more source
mBio, 2020 Fumonisin (FB) mycotoxins produced by species of the genus Fusarium detrimentally affect human and animal health upon consumption, due to the inhibition of ceramide synthase.
Slavica Janevska +7 more
doaj +1 more source
Iterative machine learning-based chemical similarity search to identify novel chemical inhibitors
Journal of Cheminformatics, 2023 Machine learning-based chemical screening has made substantial progress in recent years. However, these predictions often have low accuracy and high uncertainty when identifying new active chemical scaffolds.
Prasannavenkatesh Durai +4 more
doaj +1 more source
British Journal of Pharmacology, 2020 Conclusions This editorial illustrates major requirements that authors should con- sider before submitting articles to BJP (see Table 3 for authors' check- list).
A. Izzo +14 more
semanticscholar +1 more source
Food and Agricultural Immunology, 2018 Ovotransferrin (OVT) is one of the major proteins in avian albumen that exerts diverse biological activities. This study is aimed to investigate the antiviral effect and mechanism of OVT from the avian egg.
Yulan Zhou +6 more
doaj +1 more source
Frontiers in Microbiology, 2015 Opportunistic fungal pathogens can cause bloodstream infection and severe sepsis upon entering the blood stream of the host. The early immune response in human blood comprises the elimination of pathogens by antimicrobial peptides and innate immune cells,
Teresa eLehnert +5 more
doaj +1 more source
Applied Biological Chemistry, 2023 The high prevalence of methicillin-resistant Staphylococcus aureus (MRSA) infection threatens the effectiveness of current clinical settings. Antimicrobial photodynamic therapy (APDT) is a promising alternative to antibiotics for treating infections due ...
Ngoc Minh Ha +9 more
doaj +1 more source
Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2
Natural product reports (Print), 2019 According to a 2012 survey from the Centers for Disease Control and Prevention, approximately 18% of the U.S. population uses natural products (including plant-based or botanical preparations) for treatment or prevention of disease.
Lindsay K. Caesar, Nadja B. Cech
semanticscholar +1 more source
Microbial Chassis Development for Natural Product Biosynthesis.
Trends in Biotechnology, 2020 Engineering microbial cells to efficiently synthesize high-value-added natural products has received increasing attention in recent years. In this review, we describe the pipeline to build chassis cells for natural product production.
Xianhao Xu +4 more
semanticscholar +1 more source