Results 11 to 20 of about 8,248,717 (265)

Streptomyces cell-free systems for natural product discovery and engineering [PDF]

, 2022
Streptomyces bacteria are a major microbial source of natural products, which are encoded within so-called biosynthetic gene clusters (BGCs). This highlight discusses the emergence of native Streptomyces cell-free systems as a new tool to accelerate the ...
Lai, H-E, Li, J, Freemont, Paul S, Moore, Simon J., Lai, Hung-En, Freemont, PSS, Li, Jian, Moore, SJJ   +7 more
core   +1 more source

Facile Detection of Light-Controlled Radical Scavengers from Natural Products Using In Situ UV-LED NMR Spectroscopy

Antioxidants, 2022
With the recent development of chemical analysis technology, attention has been placed on natural light-sensitive compounds that exhibit photoreactivity to expand the structural diversity of natural product chemistry. Photochemical reactions that proceed
InWha Park, Goeun Park, Yoojin Choi, Seung-Woo Jo, Hak Cheol Kwon, Jin-Soo Park, Jin Wook Cha   +6 more
doaj   +1 more source

Limonene as natural product extraction solvent [PDF]

, 2023
First reported in 2004, and subsequently advanced by Chemat’s and other research teams in the following two decades, the use of d-limonene as natural product extraction solvent offers multiple benefits that go beyond its environmentally benign nature ...
Mario, Pagliaro, Rosaria, Ciriminna, Anne-Sylvie, Fabiano-Tixier   +2 more
core   +1 more source

Desaturation of the Sphingofungin Polyketide Tail Results in Increased Serine Palmitoyltransferase Inhibition

Microbiology Spectrum, 2022
Serine palmitoyltransferase catalyzes the first step of the sphingolipid biosynthesis. Recently, sphingolipid homeostasis has been connected to several human diseases, making serine palmitoyltransferases an interesting therapeutic target.
Sandra Hoefgen, Alexander U. Bissell, Ying Huang, Fabio Gherlone, Luka Raguž, Christine Beemelmanns, Vito Valiante   +6 more
doaj   +1 more source

Identification of Tyrosinase Inhibitors and Their Structure-Activity Relationships via Evolutionary Chemical Binding Similarity and Structure-Based Methods

Molecules, 2021
Tyrosinase is an enzyme that plays a crucial role in the melanogenesis of humans and the browning of food products. Thus, tyrosinase inhibitors that are useful to the cosmetic and food industries are required.
Prasannavenkatesh Durai, Young-Joon Ko, Jin-Chul Kim, Cheol-Ho Pan, Keunwan Park   +4 more
doaj   +1 more source

From environmental adaptation to host survival: Attributes that mediate pathogenicity of Candida auris

Virulence, 2022
Candida species are a major cause of invasive fungal infections. While Candida albicans, C. glabrata, C. parapsilosis, and C. tropicalis are the most dominant species causing life-threatening candidiasis, C.
Stefanie Allert, Daniela Schulz, Philipp Kämmer, Peter Großmann, Thomas Wolf, Sascha Schäuble, Gianni Panagiotou, Sascha Brunke, Bernhard Hube   +8 more
doaj   +1 more source

Minerals Composition and Characterization of the Hatchery Eggshell Waste Treated with Different Preparation Methods

Jurnal Ilmu dan Teknologi Hasil Ternak, 2021
The preparation process needs to be carried out in the treatment of hatchery waste. The objective of the study was to determine the mineral content and characterization of the eggshell waste after preparation.
Ahmad Iskandar Setiyawan, Diah Pratiwi, Mohammad Faiz Karimy, Safna Fauziah   +3 more
doaj   +1 more source

Natural Product Scores and Fingerprints Extracted from Artificial Neural Networks. [PDF]

, 2021
Due to their desirable properties, natural products are an important ligand class for medicinal chemists. However, due to their structural distinctiveness, traditional cheminformatic approaches, like ligand-based virtual screening, often perform worse ...
Joana, Massa, Janosch, Menke, Oliver, Koch   +2 more
core   +1 more source

Evolutionary chemical binding similarity approach integrated with 3D-QSAR method for effective virtual screening

BMC Bioinformatics, 2020
Background Despite continued efforts using chemical similarity methods in virtual screening, currently developed approaches suffer from time-consuming multistep procedures and low success rates.
Prasannavenkatesh Durai, Young-Joon Ko, Cheol-Ho Pan, Keunwan Park   +3 more
doaj   +1 more source

Natural product-based PROteolysis TArgeting Chimeras (PROTACs)

, 2022
Covering: upto 2022 Natural products have an embedded recognition of protein surfaces. They possess this property as they are produced by biosynthetic enzymes and are substrates for one or more enzymes in the biosynthetic pathway. The inherent advantages,
Liu, Miaomiao, Quinn, Ronald J, Martyn, Alexander P   +2 more
core   +1 more source