Results 21 to 30 of about 10,859,059 (267)

Cheminformatics in Natural Product‐based Drug Discovery

Molecular Informatics, 2020
This review seeks to provide a timely survey of the scope and limitations of cheminformatics methods in natural product‐based drug discovery. Following an overview of data resources of chemical, biological and structural information on natural products ...
Ya Chen, J. Kirchmair
semanticscholar   +1 more source

Analysis and Evaluation of Nutrient Components, Bioactive Substances and Heavy Metal Content of Stropharia rugosoannulata in Bo’ai County

Shipin gongye ke-ji, 2022
This study systematically determined the nutrient components, bioactive substances and heavy metal content of Stropharia rugosoannulata in Bo’ai County, and its nutritional value was analyzed and evaluated.
Bingnian JING, Xia CHANG, Lei WEI, Xiaoyang XIE, Yong ZHOU, Zhiyao WANG, Yuqing LIU, Wei WANG   +7 more
doaj   +1 more source

Creating and screening natural product libraries

Natural product reports (Print), 2020
The National Cancer Institute of the United States (NCI) has initiated a Cancer Moonshot program entitled the NCI Program for Natural Product Discovery.
Brice A. P. Wilson, C. Thornburg, C. J. Henrich, T. Grkovic, B. O’Keefe   +4 more
semanticscholar   +1 more source

Assessment of iridoid profiles in the growth period of aerial parts of Pseudolysimachion rotundum var. subintegrum and their antioxidant and MUC5AC inhibitory potential

Applied Biological Chemistry, 2023
YPL-001 is a drug substance of Pseudolysimachion rotundum var. subintegrum and has been reported to be a potent COPD inhibitor. For the first time, this study demonstrated a correlation among the iridoid constituents, antioxidants, and MUC5AC inhibition ...
Soobin Song, Doo-Young Kim, Seon Min Oh, So-Yeun Woo, Il-joo Kim, Mun-Ock Kim, Ji-Yoon Park, Namho Kim, Hae-Young Kim, Juhee Lee, Sang Yoon Kim, Bang Yeon Hwang, Hyung Won Ryu, Sei-Ryang Oh   +13 more
doaj   +1 more source

Anticancer Effects of Seaweed-Derived Bioactive Compounds

Applied Sciences, 2021
Cancer remains a major life-threatening disease worldwide. The development of anticancer drugs using natural products obtained from marine organisms has been proposed as an alternative approach.
Heesu Lee, Baskar Selvaraj, Jae Wook Lee
doaj   +1 more source

Natural Product

Definitions, 2020
Amaryllidaceae alkaloids (AAs) are a unique class of specialized metabolites containing heterocyclic nitrogen bridging that play a distinct role in higher plants.
T. Jayawardena, Natacha Mérindol, A. Nuwan, S. Liyanage, Isabel Desgagn´e-Penix   +4 more
semanticscholar   +1 more source

Natural products in drug discovery: advances and opportunities

Nature reviews. Drug discovery, 2021
Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases.
A. Atanasov, S. Zotchev, V. Dirsch, Ilkay Erdogan Maciej Judith M. Davide Wolfram Rudolf Edw Orhan Banach Rollinger Barreca Weckwerth Bauer Bay, I. Orhan, M. Banach, J. Rollinger, D. Barreca, W. Weckwerth, R. Bauer, E. Bayer, M. Majeed, A. Bishayee, V. Bochkov, G. Bonn, N. Braidy, F. Bucar, A. Cifuentes, G. D’Onofrio, Michael A. Bodkin, M. Diederich, A. Dinkova-Kostova, T. Efferth, Khalid El Bairi, N. Arkells, Tai-Ping Fan, B. Fiebich, M. Freissmuth, M. Georgiev, S. Gibbons, K. Godfrey, Christian W. Gruber, J. Heer, Lukas A. Huber, E. Ibáñez, A. Kijjoa, A. Kiss, Aiping Lu, F. A. Macias, Mark J. S. Miller, A. Mocan, Rolf Müller, Ferdinando Nicoletti, George Perry, V. Pittalà, L. Rastrelli, M. Ristow, G. Russo, A. S. Silva, D. Schuster, H. Sheridan, K. Skalicka‐Woźniak, L. Skaltsounis, E. Sobarzo-Sánchez, D. Bredt, H. Stuppner, A. Sureda, N. Tzvetkov, R. A. Vacca, Bharat B. Aggarwal, M. Battino, Francesca Giampieri, M. Wink, J. Wolfender, Jianbo Xiao, A. Yeung, G. Lizard, M. Popp, Michael Heinrich, I. Berindan‐Neagoe, M. Stadler, M. Daglia, R. Verpoorte, C. Supuran   +73 more
semanticscholar   +1 more source

Lactic Acid Bacteria Isolates and the Microbiome of Cincalok, Tempoyak, and Mandai: A Traditional Fermented Food from Kalimantan Island, Indonesia

International Journal of Food Science
Indonesia has abundant traditional fermented food with various lactic acid bacteria (LAB), which can be developed into probiotics for pharmaceutical and functional food and feed products.
Retno Murwani, Refa Anggraeni, Gregorius Nico Adi Setiawan, Putri Dyah Astari, Ni Kadek Dita Cahyani, Mada Triandala Sibero, Ambariyanto Ambariyanto   +6 more
doaj   +1 more source

Automated quantification of the phagocytosis of Aspergillus fumigatus conidia by a novel image analysis algorithm

Frontiers in Microbiology, 2015
Studying the pathobiology of the fungus Aspergillus fumigatus has gained a lot of attention in recentyears. This is due to the fact that this fungus is a human pathogen that can cause severe diseases, likeinvasive pulmonary aspergillosis in ...
Kaswara eKraibooj, Hanno eSchoeler, Carl Magnus Svensson, Axel A Brakhage, Marc Thilo eFigge   +4 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source