Results 21 to 30 of about 8,248,717 (265)
68 million natural product-like compound database generated via molecular language processing [PDF]
, 2023 Natural products are a rich resource of bioactive compounds for valuable applications across multiple fields such as food, agriculture, medicine. For natural product discovery, high throughput in silico screening offers a cost-effective alternative to ...
Shi Jun, Ang +9 more
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mBio, 2020 Fumonisin (FB) mycotoxins produced by species of the genus Fusarium detrimentally affect human and animal health upon consumption, due to the inhibition of ceramide synthase.
Slavica Janevska +7 more
doaj +1 more source
Iterative machine learning-based chemical similarity search to identify novel chemical inhibitors
Journal of Cheminformatics, 2023 Machine learning-based chemical screening has made substantial progress in recent years. However, these predictions often have low accuracy and high uncertainty when identifying new active chemical scaffolds.
Prasannavenkatesh Durai +4 more
doaj +1 more source
Bioactive natural products from Bacteroidetes
, 2022 10451065Bacteria representing the phylum Bacteroidetes produce a diverse range of natural products, including polyketides, peptides and lactams. Here, we discuss unique aspects of the bioactive compounds discovered thus far, and the corresponding ...
Spohn, Marius S. +2 more
core +1 more source
Establishment of a Phenotypic-based Sand Dollar Fellaster zelandiae Embryo Development Assay and its Application in Defining the Structure-Activity Relationship of Discorhabdin Alkaloids [PDF]
, 2013 An embryo development assay using the common New Zealand intertidal species Fellaster zelandiae (sand dollar) is presented. The assay was validated by comparing activity profiles of a range of discorhabdin alkaloids, natural products sourced from ...
Cropp, Brent R., Grkovic, Tanja
core +2 more sources
Cell factory engineering for improved production of natural products [PDF]
, 2019 Natural product biosynthesis is inherently linked with the primary metabolism in terms of providing precursors and co-factors. Thus, even though it is important to improve the performance of natural product biosynthetic enzymes in building efficient cell
Nielsen, Jens +2 more
core +1 more source
Food and Agricultural Immunology, 2018 Ovotransferrin (OVT) is one of the major proteins in avian albumen that exerts diverse biological activities. This study is aimed to investigate the antiviral effect and mechanism of OVT from the avian egg.
Yulan Zhou +6 more
doaj +1 more source
Applied Biological Chemistry, 2023 The high prevalence of methicillin-resistant Staphylococcus aureus (MRSA) infection threatens the effectiveness of current clinical settings. Antimicrobial photodynamic therapy (APDT) is a promising alternative to antibiotics for treating infections due ...
Ngoc Minh Ha +9 more
doaj +1 more source
Frontiers in Microbiology, 2015 Opportunistic fungal pathogens can cause bloodstream infection and severe sepsis upon entering the blood stream of the host. The early immune response in human blood comprises the elimination of pathogens by antimicrobial peptides and innate immune cells,
Teresa eLehnert +5 more
doaj +1 more source
Applied Biological Chemistry, 2023 YPL-001 is a drug substance of Pseudolysimachion rotundum var. subintegrum and has been reported to be a potent COPD inhibitor. For the first time, this study demonstrated a correlation among the iridoid constituents, antioxidants, and MUC5AC inhibition ...
Soobin Song +13 more
doaj +1 more source