Results 41 to 50 of about 4,560,586 (338)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Discovery of 15-deoxynaphthomycins activating the antioxidant NRF2-ARE pathway from Streptomyces sp. N50 via genome mining, global regulator introduction, and molecular networking

Microbial Cell Factories
Genome mining is a promising avenue for expanding the repertoire of microbial natural products, which are important for drug development. This approach involves predicting genetically encoded small molecules by examining bacterial genomes via accumulated
Min-Seon Kim, Baskar Selvaraj, Hee-Tae Yeo, Jun-Su Park, Jae Wook Lee, Jin-Soo Park   +5 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Regional comparison study of Epimedium koreanum using UHPLC-QTOF/MS-based metabolomics approach

Applied Biological Chemistry
The untargeted metabolomics-based molecular networking approach combined with multivariate analysis, proves to be an effective strategy for distinguishing raw materials in herbal medicine according to specific criteria.
Alfan Danny Arbianto, Min Kim, Seon Min Oh, Hyun-Jae Jang, Hyung Won Ryu, Jin-Hyub Paik, Sei-Ryang Oh, Jongmin Ahn   +7 more
doaj   +1 more source

A new high-performance heterologous fungal expression system based on regulatory elements from the Aspergillus terreus terrein gene cluster

Frontiers in Microbiology, 2015
Recently, the Aspergillus terreus terrein gene cluster was identified and selected for development of a new heterologous expression system. The cluster encodes the specific transcription factor TerR that is indispensable for terrein cluster induction. To
Markus eGressler, Peter eHortschansky, Elena eGeib, Matthias eBrock, Matthias eBrock   +4 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Enhanced diastereomeric mixture analysis through integration of quantum chemical calculations with spatio-conformational information obtained from ultraselective NMR techniques

Applied Biological Chemistry
Nuclear Magnetic Resonance (NMR) spectroscopy has become indispensable for elucidating molecular structures in pharmaceutical and natural product chemistry, where precise stereochemical configurations critically determine biological activities and ...
Miyeon Bang, Jin Wook Cha
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

On the Hochschild homology of open Frobenius algebras [PDF]

, 2015
We prove that the shifted Hochschild chain complex $C\_*(A,A)[m]$ of a symmetric open Frobenius algebra $A$ of degree $m$ has a natural homotopy coBV-algebra structure.
Abbaspour, Hossein
core   +2 more sources

Natural Connection with Totally Skew-Symmetric Torsion on Riemannian Almost Product Manifolds [PDF]

, 2011
On a Riemannian almost product manifold $(M,P,g)$ we consider a linear connection preserving the almost product structure $P$ and the Riemannian metric $g$ and having a totally skew-symmetric torsion.
DIMITAR MEKEROV, Gauduchon P., Gray A., Helgason S., Lichnerowicz A., Lichnerowicz A., MANCHO MANEV, Mekerov D., Mihova V., Staikova M., Staikova M., Yano K.   +11 more
core   +1 more source