Results 41 to 50 of about 7,942,931 (308)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Memòria resum d’actuacions Parc Natural dels Ports 2020 [PDF]

, 2021
Gestió efectuada durant el 2020 al Parc Natural dels Ports, destacar les accions estratègiques i les fites més rellevants en cada un dels àmbits i línies de treball.info:eu-repo/semantics ...
Parc Natural dels Ports
core  

Bioactive natural products from Bacteroidetes

, 2022
10451065Bacteria representing the phylum Bacteroidetes produce a diverse range of natural products, including polyketides, peptides and lactams. Here, we discuss unique aspects of the bioactive compounds discovered thus far, and the corresponding ...
Spohn, Marius S., Schäberle, Till Friedrich, Brinkmann, Stephan   +2 more
core   +1 more source

Micheliolide ameliorates colon cancer cachexia by modulating gut microbiota–immune signaling via Phocaeicola vulgatus enrichment

Microbiome
Background Cancer cachexia profoundly impacts patient survival and quality of life. Current treatments fail to halt this trajectory, highlighting an urgent clinical need for host-directed therapies capable of uncoupling skeletal muscle wasting from tumor
Hye-Young Youn, Sunhee Park, Huitae Min, Nguyen Bao Ngoc, Young Hyun Kim, Kwang-Hyun Cha, Young Tae Park, Hyog Young Kwon, Choong-Gu Lee, Myungsuk Kim   +9 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Anticancer agents from diverse natural sources [PDF]

, 2014
Cancer is one of the major causes of death and the number of new cases, as well as the number of individuals living with cancer, is expanding continuously.
Riley, Darren Lyall, Khazir, Jabeena, Cowan, Don A., Mir, Bilal Ahmad, Pilcher, Lynne A.   +4 more
core   +1 more source

Enhanced diastereomeric mixture analysis through integration of quantum chemical calculations with spatio-conformational information obtained from ultraselective NMR techniques

Applied Biological Chemistry
Nuclear Magnetic Resonance (NMR) spectroscopy has become indispensable for elucidating molecular structures in pharmaceutical and natural product chemistry, where precise stereochemical configurations critically determine biological activities and ...
Miyeon Bang, Jin Wook Cha
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

N-2, N-2, 7-trimethylguanine, a new trimethylated guanine natural product from the New Zealand ascidian, Lissoclinum notti

, 2001
From the New Zealand ascidian, Lissoclinum notti a new natural product, N-2,N-2,7-trimethylguanine (1) has been isolated.
Copp, Brent, Babcock, Russell, Pearce, Allison, Lambert, G   +3 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source