Results 41 to 50 of about 10,859,059 (267)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Anticancer Activity of Phytochemicals from Nepalese Plants: A Review of Active Phytochemicals and Screening Methods

Natural Product Communications
Medicinal plants have long been sought after as a source of potentially valuable compounds to combat cancer. This review purposes that the phytochemicals found in Nepalese medicinal plants possess significant potential anticancer activity, which calls ...
Anup Luitel, Lalit Mohan Pant, Niru Thapa, Manika Shrestha, Anup Adhikari, Ronak Shrestha, Ashwinee Kumar Shrestha, Rajan Shrestha, Janardan Lamichhane   +8 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Targeting Bacterial Genomes for Natural Product Discovery

TIPS - Trends in Pharmacological Sciences, 2019
Bacterial natural products and their analogues constitute more than half of the new small molecule drugs developed over the last several decades. Despite this success, interest in natural products from major pharmaceutical companies has decreased even as
Edward Kalkreuter, Guohui Pan, Alexis J. Cepeda, B. Shen   +3 more
semanticscholar   +1 more source

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019.

Journal of Natural Products, 2020
This review is an updated and expanded version of the five prior reviews that were published in this journal in 1997, 2003, 2007, 2012, and 2016. For all approved therapeutic agents, the time frame has been extended to cover the almost 39 years from the ...
D. Newman, G. Cragg
semanticscholar   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation

bioRxiv, 2018
Nimbolide, a terpenoid natural product derived from the Neem tree, impairs cancer pathogenicity; however, the direct targets and mechanisms by which nimbolide exerts its effects are poorly understood. Here, we used activity-based protein profiling (ABPP)
Jessica N. Spradlin, Xirui Hu, Carl C. Ward, S. Brittain, Michael D. Jones, Lisha Ou, Milton To, A. Proudfoot, E. Ornelas, Mikias Woldegiorgis, James A. Olzmann, D. Bussiere, J. Thomas, John A. Tallarico, J. McKenna, M. Schirle, T. J. Maimone, Daniel K. Nomura   +17 more
semanticscholar   +1 more source