Results 51 to 60 of about 10,859,059 (267)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The hidden enzymology of bacterial natural product biosynthesis
Nature Reviews Chemistry, 2019 Bacterial natural products display astounding structural diversity, which, in turn, endows them with a remarkable range of biological activities that are of significant value to modern society.
T. Scott, J. Piel
semanticscholar +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
mBioSphingofungins are sphinganine analog mycotoxins acting as inhibitors of serine palmitoyl transferases, enzymes responsible for the first step in the sphingolipid biosynthesis.
Katarina Jojić +9 more
doaj +1 more source
Aporphine Alkaloids from the Chinese Tree
Natural Product Communications, 2007 Three new oxygenated noraporphine alkaloids were isolated from the bark of the Chinese tree Neolitsea aurata var. paraciculata. The new compounds, (+)-11-methoxynorcassythicine, (+)-11-methoxynorneolitsine, (+)-11-methoxynorboldine, were isolated along ...
Malcolm S. Buchanan +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Resistance-Gene Directed Discovery of a Natural Product Herbicide with a New Mode of Action
Nature, 2018 Bioactive natural products have evolved to inhibit specific cellular targets and have served as lead molecules for health and agricultural applications for the past century1–3.
Yan Yan +9 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
First Stereoselective Total Synthesis of (3)-De--methylbotryosphaeriodiplodin
Natural Product Communications, 2019 A simple and highly efficient first stereoselective total synthesis of a benzofused macrocyclic lactone, ( 3S,7R )-de- O -methylbotryosphaeriodiplodin has been accomplished utilizing Jacobson's kinetic resolution, Marouka asymmetric allylation, Stille ...
Jhillu S. Yadav +5 more
doaj +1 more source