Results 51 to 60 of about 1,233,997 (314)

Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function [PDF]

, 2017
Cytochrome P450 enzymes (P450s) are some of the most exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in steroid biosynthesis and drug metabolism in humans, P450s are key players in natural product biosynthetic ...
Ben Shen, Chang, Chin-Yuan, Ming Ma, Jeffrey D. Rudolf, Chin-Yuan Chang, Rudolf, Jeffrey D., Shen, Ben, Ma, Ming   +7 more
core   +1 more source

Regional comparison study of Epimedium koreanum using UHPLC-QTOF/MS-based metabolomics approach

Applied Biological Chemistry
The untargeted metabolomics-based molecular networking approach combined with multivariate analysis, proves to be an effective strategy for distinguishing raw materials in herbal medicine according to specific criteria.
Alfan Danny Arbianto, Min Kim, Seon Min Oh, Hyun-Jae Jang, Hyung Won Ryu, Jin-Hyub Paik, Sei-Ryang Oh, Jongmin Ahn   +7 more
doaj   +1 more source

A new high-performance heterologous fungal expression system based on regulatory elements from the Aspergillus terreus terrein gene cluster

Frontiers in Microbiology, 2015
Recently, the Aspergillus terreus terrein gene cluster was identified and selected for development of a new heterologous expression system. The cluster encodes the specific transcription factor TerR that is indispensable for terrein cluster induction. To
Markus eGressler, Peter eHortschansky, Elena eGeib, Matthias eBrock, Matthias eBrock   +4 more
doaj   +1 more source

Association Between Dinutuximab Beta Exposure and Post‐End‐of‐Treatment Survival in Neuroblastoma: A Weighted Patient‐Level Analysis of Three Clinical Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko, Holger N. Lode, Alberto Garaventa, Carla Manzitti, Roberto Luksch, Dominique Valteau‐Couanet, Marion Gambart, John Anderson, Juliet Gray, Adela Canete, Lucas Moreno, Aleksandra Wieczorek, Cormac Owens, Shifra Ash, Isaac Yaniv, Genevieve Laureys, Hans Loibner, Katarzyna Śladowska, Ruth Ladenstein, Paweł Kawalec   +19 more
wiley   +1 more source

Micheliolide ameliorates colon cancer cachexia by modulating gut microbiota–immune signaling via Phocaeicola vulgatus enrichment

Microbiome
Background Cancer cachexia profoundly impacts patient survival and quality of life. Current treatments fail to halt this trajectory, highlighting an urgent clinical need for host-directed therapies capable of uncoupling skeletal muscle wasting from tumor
Hye-Young Youn, Sunhee Park, Huitae Min, Nguyen Bao Ngoc, Young Hyun Kim, Kwang-Hyun Cha, Young Tae Park, Hyog Young Kwon, Choong-Gu Lee, Myungsuk Kim   +9 more
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Anti-atherogenic Effects of Soybean (Glycine max) Seed and Ginger (Zingiber officinale) Rhizome Extracts on Type 2 Diabetic Rat Model [PDF]

, 2022
[ARCHIVES] Copyright Article From:Tropical Journal of Natural Product Research (TJNPR)Diabetes mellitus (DM) is linked to an increase in dyslipidemia, which is associated with atherosclerosis, one of the leading causes of cardiovascular ...
Wibisono, Nugroho, Triliana, Rahma, Purnomo, Yudi   +2 more
core  

Enhanced diastereomeric mixture analysis through integration of quantum chemical calculations with spatio-conformational information obtained from ultraselective NMR techniques

Applied Biological Chemistry
Nuclear Magnetic Resonance (NMR) spectroscopy has become indispensable for elucidating molecular structures in pharmaceutical and natural product chemistry, where precise stereochemical configurations critically determine biological activities and ...
Miyeon Bang, Jin Wook Cha
doaj   +1 more source

THE PRODUCTION AND NATURE OF STREPTOCOLYSIN. [PDF]

JAMA: The Journal of the American Medical Association, 1903
In 1897 Bordet1drew attention to the fact that there generally is more or less hemolysis in the blood of a rabbit which has died of streptococcus infection. This hemolysis is not constantly observed, but was present, for instance, in 37 of 40 rabbits dying of streptococcus infection, in which it was looked for in this laboratory during the last eight ...
openaire   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source