Results 51 to 60 of about 7,942,931 (308)

Nephrotoxicity of Natural Products [PDF]

open access: yesBlood Purification, 2016
<b><i>Background:</i></b> The manufacture and sale of natural products constitute a multi-billion dollar industry. Nearly a third of the American population admit to using some form of complementary or alternative medicine, with many using them in addition to prescription medications.
Mary, Nauffal, Steven, Gabardi
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Anticancer Activity of Phytochemicals from Nepalese Plants: A Review of Active Phytochemicals and Screening Methods

open access: yesNatural Product Communications
Medicinal plants have long been sought after as a source of potentially valuable compounds to combat cancer. This review purposes that the phytochemicals found in Nepalese medicinal plants possess significant potential anticancer activity, which calls ...
Anup Luitel   +8 more
doaj   +1 more source

Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters

open access: yesFrontiers in Microbiology, 2015
Microorganisms form diverse multispecies communities in various ecosystems. The high abundance of fungal and bacterial species in these consortia results in specific communication between the microorganisms.
Tina eNetzker   +13 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Molecular Docking of Soybean (Glycine max) Seed and Ginger (Zingiber officinale) Rhizome Components as Anti-Diabetic Through Inhibition of Dipeptidyl Peptidase 4 (DPP-4) and Alpha-Glucosidase Enzymes

open access: yes, 2021
[ARCHIVES] Copyright Article From:Tropical Journal of Natural Product Research (TJNPR)Dipeptidyl Peptidase-4 (DPP-4) and alpha-glucosidase (α-glucosidase) are enzymes involved in carbohydrate metabolism.
Hakim, Reza   +3 more
core   +1 more source

Bioactive Natural Products [PDF]

open access: yesJournal of Chemistry, 2013
Bioactive natural products have never ceased to play an important role in the search of novel therapeutic agents. Natural products from the nature such as the plant and marine sources form an integral part of the living system, and they have existed ever since the beginning of life.Therefore, it is undeniable that works related to natural products ...
Hadi, A. Hamid A.   +2 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

A new secondary metabolite from Korean traditional herb plant hovenia dulcis

open access: yes, 2018
Investigation of chemical compounds from the butanol soluble layer of the traditional herb Hovenia dulcis has led to the isolation of a new compound, identified as 2-methoxybenzoic acid-5-O-α-L-rhamnopyranoside (1), along with three known compounds ...
남상집
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

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