Results 71 to 80 of about 7,942,931 (308)
Direct construction of vicinal all-carbon quaternary stereocenters in natural product synthesis
, 2015 Molecules containing vicinal all-carbon quaternary stereocenters are found in many secondary metabolites, and they exhibit a variety of biological and pharmacological activities.
Yang, Zhen +3 more
core +1 more source
, 2020 The chemical composition is detailed in this paper of the essential oils of aerial parts of Artemisia campestris ssp. campestris, collected from ten different locations in Lithuania. The major component in all the oils was caryophellene oxide (8.5-38.8%),
Laffont-Schwob, Isabelle +5 more
core +1 more source
Unzipping Natural Products: Improved Natural Product Structure Predictions by Ensemble Modeling and Fingerprint Matching [PDF]
, 2018 This pre-print explores ensemble modeling of natural product targets to match chemical structures to precursors found in large open-source gene cluster repository antiSMASH. Commentary on method, effectiveness, and limitations are enclosed.
Yohann, Potier +5 more
core +1 more source
Functional Diversification and Structural Origins of Plant Natural Product Methyltransferases
, 2022 In plants, methylation is a common step in specialized metabolic pathways, leading to a vast diversity of natural products. The methylation of these small molecules is catalyzed by S-adenosyl-l-methionine (SAM)-dependent methyltransferases, which are ...
Stephanie Provenzano +5 more
core +1 more source
THE PRODUCTION AND NATURE OF STREPTOCOLYSIN. [PDF]
JAMA: The Journal of the American Medical Association, 1903 In 1897 Bordet1drew attention to the fact that there generally is more or less hemolysis in the blood of a rabbit which has died of streptococcus infection. This hemolysis is not constantly observed, but was present, for instance, in 37 of 40 rabbits dying of streptococcus infection, in which it was looked for in this laboratory during the last eight ...
openaire +1 more source
Natural Product Reports, 2018 This review of 2016 literature describes the structures and biological activities of 1277 new marine natural products and the structure revision and absolute configuration of previously reported MNPs. The chemical diversity of 28 609 MNPs reported since 1957 is also investigated and compared to that of approved drugs.
John W. Blunt +5 more
openaire +4 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Discovery and characterization of natural products that act as pheromones in fish
, 2018 Fish use a diverse collection of molecules to communicate with conspecifics. Since Karlson and Luscher termed these molecules 'pheromones', chemists and biologists have joined efforts to characterize their structures and functions. In particular,
Li K(李可)
core +1 more source
Amyloid as a natural product [PDF]
The Journal of Cell Biology, 2003 Amyloid fibrils, such as those found in Alzheimer's and the gelsolin amyloid diseases, result from the misassembly of peptides produced by either normal or aberrant intracellular proteolytic processing. A paper in this issue by Marks and colleagues (Berson et al., 2003) demonstrates that intra-melanosome fibrils are formed through normal biological ...
Kelly, Jeffery W., Balch, William E.
openaire +2 more sources
mBioSphingofungins are sphinganine analog mycotoxins acting as inhibitors of serine palmitoyl transferases, enzymes responsible for the first step in the sphingolipid biosynthesis.
Katarina Jojić +9 more
doaj +1 more source