Results 71 to 80 of about 10,859,059 (267)

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Data-based reconstruction of gene regulatory networks of fungal pathogens

Frontiers in Microbiology, 2016
In the emerging field of systems biology of fungal infection, one of the central roles belongs to the modelling of gene regulatory networks (GRNs). Utilising omics-data, GRNs can be predicted by mathematical modelling. Here, we review current advances of
Reinhard eGuthke, Silvia eGerber, Theresia eConrad, Sebastian eVlaic, Saliha eDurmus, Tunahan eCakir, Erdogan eSevilgen, Ekaterina eShelest, Jörg eLinde   +8 more
doaj   +1 more source

NPASS: natural product activity and species source database for natural product research, discovery and tool development

Nucleic Acids Res., 2017
There has been renewed interests in the exploration of natural products (NPs) for drug discovery, and continuous investigations of the therapeutic claims and mechanisms of traditional and herbal medicines.
Xian Zeng, Peng Zhang, Weidong He, Chu Qin, S. Chen, Lin Tao, Yali Wang, Ying Tan, Dan Gao, Bo-hua Wang, Zhe Chen, Weiping Chen, Yu Yang Jiang, Y. Chen   +13 more
semanticscholar   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

How to predict molecular interactions between species?

Frontiers in Microbiology, 2016
Organisms constantly interact with other species through physical contact which leads to chan-ges on the molecular level, for example the transcriptome. These changes can be monitored forall genes, with the help of high-throughput experiments such as RNA-
Jörg eLinde, Sylvie eSchulze, Jana eSchleicher, Reinhard eGuthke   +3 more
doaj   +1 more source

NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening

ACS Chemical Biology, 2018
The US National Cancer Institute’s (NCI) Natural Product Repository is one of the world’s largest, most diverse collections of natural products containing over 230,000 unique extracts derived from plant, marine, and microbial organisms that have been ...
C. Thornburg, J. Britt, Jason R. Evans, R. Akee, J. Whitt, Spencer K Trinh, Matthew J Harris, Jerell R Thompson, Teresa L Ewing, S. Shipley, P. Grothaus, D. Newman, J. Schneider, T. Grkovic, B. O’Keefe   +14 more
semanticscholar   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Isolation of Lactic Acid Bacteria with Cholesterol-Lowering Activity from Digestive Tracts of Indonesian Native Chickens

Media Peternakan, 2017
The aim of the study was to identify the cholesterol-lowering activity of indigenous lactic acid bacteria isolated from the small intestine, cecum, and colon of Indonesian native chickens and evaluated for bile salt hydrolase (BSH) activity in vitro by ...
H. Julendra, Ade Erma Suryani, Lusty Istiqomah, Ema Damayanti, Muslih Anwar, Naditya Fitriani   +5 more
doaj   +1 more source

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

Frontiers in Pharmacology, 2018
Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy are the common cancer treatments. However, the development of adverse effects resulting from chemotherapy and radiotherapy hinders the clinical use, and negatively ...
Qing-Yu Zhang, Fei-Xuan Wang, Ke-Ke Jia, L. Kong   +3 more
semanticscholar   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source