Results 91 to 100 of about 1,233,997 (314)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

First Stereoselective Total Synthesis of (3)-De--methylbotryosphaeriodiplodin

Natural Product Communications, 2019
A simple and highly efficient first stereoselective total synthesis of a benzofused macrocyclic lactone, ( 3S,7R )-de- O -methylbotryosphaeriodiplodin has been accomplished utilizing Jacobson's kinetic resolution, Marouka asymmetric allylation, Stille ...
Jhillu S. Yadav, Chitteti Divya Vani, Mule Chowdeswari, K. Ananthalakshmi, N. Bhasker, Basi V. Subba Reddy   +5 more
doaj   +1 more source

Systems biology of fungal infection

Frontiers in Microbiology, 2012
Elucidation of pathogenicity mechanisms of the most important human pathogenic fungi, Aspergillus fumigatus and Candida albicans, has gained great interest in the light of the steadily increasing number of cases of invasive fungal infections.A key ...
Fabian eHorn, Thorsten eHeinekamp, Olaf eKniemeyer, Johannes ePollmächer, Vito eValiante, Axel A Brakhage, Axel A Brakhage   +6 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The palmitoyl-CoA ligase Fum16 is part of a Fusarium verticillioides fumonisin subcluster involved in self-protection

mBio
Fusarium verticillioides produces the mycotoxin fumonisin B1 (FB1), which disrupts sphingolipid biosynthesis by inhibiting ceramide synthase and affects the health of plants, animals, and humans. The means by which F. verticillioides protects itself from
Fabio Gherlone, Katarina Jojić, Ying Huang, Sandra Hoefgen, Vito Valiante, Slavica Janevska   +5 more
doaj   +1 more source

Aspergillus fumigatus melanins: Interference with the host endocytosis pathway and impact on virulence

Frontiers in Microbiology, 2013
The opportunistic human pathogenic fungus Aspergillus fumigatus produces at least two types of melanin, namely pyomelanin and dihydroxynaphthalene (DHN) melanin.
Thorsten eHeinekamp, Andreas eThywissen, Juliane eMacheleidt, Sophia eKeller, Vito eValiante, Axel A Brakhage, Axel A Brakhage   +6 more
doaj   +1 more source

Natural products in cosmetics

Natural Products and Bioprospecting, 2022
AbstractThe global cosmetics market reached US$500 billion in 2017 and is expected to exceed US$800 billion by 2023, at around a 7% annual growth rate. The cosmetics industry is emerging as one of the fastest-growing industries of the past decade. Data shows that the Chinese cosmetics market was US$60 billion in 2021.
openaire   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Optimized psilocybin production in tryptophan catabolism‐repressed fungi

Microbial Biotechnology
The high therapeutic potential of psilocybin, a prodrug of the psychotropic psilocin, holds great promise for the treatment of mental disorders such as therapy‐refractory depression, alcohol use disorder and anorexia nervosa.
Slavica Janevska, Sophie Weiser, Ying Huang, Jun Lin, Sandra Hoefgen, Katarina Jojić, Amelia E. Barber, Tim Schäfer, Janis Fricke, Dirk Hoffmeister, Lars Regestein, Vito Valiante, Johann E. Kufs   +12 more
doaj   +1 more source

Candida albicans induces Metabolic Reprogramming in human NK cells and responds to Perforin with a Zinc Depletion Response

Frontiers in Microbiology, 2016
As part of the innate immune system, natural killer (NK) cells are directly involved in the response to fungal infections. Perforin has been identified as the major effector molecule acting against many fungal pathogens.
Daniela eHellwig, Jessica eVoigt, Maria eBouzani, Jürgen eLöffler, Daniela eAlbrecht-Eckardt, Michael eWeber, Sascha eBrunke, Ronny eMartin, Oliver eKurzai, Oliver eKurzai, Kerstin eHünniger   +10 more
doaj   +1 more source