Results 101 to 110 of about 4,560,586 (338)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Elucidation of the protective effect of schisandrin C originating from Schisandra chinensis (Turcz.) Baill. against indomethacin-induced intestinal injury by combining network pharmacology, molecular docking, and experimental validation

Applied Biological Chemistry
Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), especially indomethacin, has severe adverse effects on the gastrointestinal system. Schisandra chinensis (Turcz.) Baill., an herbal medicine used to treat several gastrointestinal diseases ...
Son Hung Tran, Uyen Tran Tu Nguyen, Mi Ri Kim, Hee Ju Lee, Esther Youn, Won Young Bae, Suk Woo Kang, Won Kyu Kim, Ki Young Choi, Keunwan Park, Kyungsu Kang   +10 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Synthesis, Bioevaluation, Structure-Activity Relationship and Docking Studies of Natural Product Inspired (Z)-3-benzylideneisobenzofuran-1(3H)-ones as Highly Potent antioxidants and Antiplatelet agents [PDF]

, 2020
Bharti Rajesh Kumar Shyamlal, Lalit Yadav, Mohit K. Tiwari, Manas Mathur, Jaroslav Prikhodko, I. V. Mashevskaya, Dharmendra Kumar Yadav, Sandeep Chaudhary   +7 more
openalex   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Natural Products Chemistry & Research [PDF]

, 2019
Zelalem Abdisa, Kalkidan Tarekegn, A Devanesan, T Zipora, Bag Smilin, G Deviram, O Ogbole, P Segun, P Fasinu, S Rimjhim, N Kumari, K Jainendra, S Nemanja, M Tatjana, Z Bojan, S Vesna, M Mzwandile, R Rodney, Z Zodwa, K Muhammad, R Muhammad, U Hizb, A Mazhar, K Thanzami, C Malsawmtluangi, H Lalhlenmawiaa, S Veenus, Jos Cs De Oliveiraa, P Juceni, Jorge Davida, T Amene, T Getachew, G Mirutse, S Workineh, S Volodymyr, R Melissa, I Shabana, Z Jianping, E Tadesse, T Dereje, G Mirutse, R Sawant, A Godghate, Sahira Bk, & Cathrine, L, R Bounar, L Takia, R Messaoud, C Pierre, Mahfuza K, I Ekramu, I Rafiku, A Aziz, V Thanh, J Christopher, C Michael, D Phuong, D Dixon, G Jeena, A Tesfaye, G Terefe, M Giday, W Shibeshi, M Fufa, F Deressa, T Deyou, N Abdisa, A Kaisarun, C Emma, L Wendy, Y Ping, G Ashenafi, A Mohammedbrhan, T Wondmagegn, E Abyot, S Balakumar, S Rajan, T Thirunalasundari, S Jeeva, G Rukunga, P Waterman, V Samoylenko, M Jacob, S Khan, J Zhao, K Bacha, Y Tariku, F Gebreyesus, S Zerihun, Q Abdul, A Syed, M Waheed, J Sayyed, H Solomon, S Mohammed, I Hamzat, M Bashir, H Saidu, P Erasto   +99 more
openalex   +1 more source

Role of Plant-based Natural Products in the Treatment of Type 2 Diabetes

, 2021
O. J. Jinarathne, K. S. Jayasiri, K. R. Hulugalla, W.M. A.N. Wanasinghe, Sashiprabha M. Vithanarachchi   +4 more
openalex   +2 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source