Results 81 to 90 of about 8,248,717 (265)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

The palmitoyl-CoA ligase Fum16 is part of a Fusarium verticillioides fumonisin subcluster involved in self-protection

mBio
Fusarium verticillioides produces the mycotoxin fumonisin B1 (FB1), which disrupts sphingolipid biosynthesis by inhibiting ceramide synthase and affects the health of plants, animals, and humans. The means by which F. verticillioides protects itself from
Fabio Gherlone, Katarina Jojić, Ying Huang, Sandra Hoefgen, Vito Valiante, Slavica Janevska   +5 more
doaj   +1 more source

Aspergillus fumigatus melanins: Interference with the host endocytosis pathway and impact on virulence

Frontiers in Microbiology, 2013
The opportunistic human pathogenic fungus Aspergillus fumigatus produces at least two types of melanin, namely pyomelanin and dihydroxynaphthalene (DHN) melanin.
Thorsten eHeinekamp, Andreas eThywissen, Juliane eMacheleidt, Sophia eKeller, Vito eValiante, Axel A Brakhage, Axel A Brakhage   +6 more
doaj   +1 more source

Natural Product Primary Sulfonamides and Primary Sulfamates

, 2015
Primary sulfonamide and primary sulfamate functional groups feature prominently in the structures of U.S. FDA-approved drugs. However, the natural product chemical space contains few examples of these well-known zinc-binding chemotypes, with just two ...
Mujumdar, Prashant, Poulsen, Sally-Ann
core   +1 more source

Biological control of stored-product insects in commodities, food processing facilities and museums [PDF]

, 2010
Non-chemical control methods have gained importance in integrated pest management, as policies aiming to minimize the application of residual chemical insecticides are being adopted by many companies, and a growing market of organic produce.
Schöller, Matthias, Schöller, M.
core   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Optimized psilocybin production in tryptophan catabolism‐repressed fungi

Microbial Biotechnology
The high therapeutic potential of psilocybin, a prodrug of the psychotropic psilocin, holds great promise for the treatment of mental disorders such as therapy‐refractory depression, alcohol use disorder and anorexia nervosa.
Slavica Janevska, Sophie Weiser, Ying Huang, Jun Lin, Sandra Hoefgen, Katarina Jojić, Amelia E. Barber, Tim Schäfer, Janis Fricke, Dirk Hoffmeister, Lars Regestein, Vito Valiante, Johann E. Kufs   +12 more
doaj   +1 more source

Candida albicans induces Metabolic Reprogramming in human NK cells and responds to Perforin with a Zinc Depletion Response

Frontiers in Microbiology, 2016
As part of the innate immune system, natural killer (NK) cells are directly involved in the response to fungal infections. Perforin has been identified as the major effector molecule acting against many fungal pathogens.
Daniela eHellwig, Jessica eVoigt, Maria eBouzani, Jürgen eLöffler, Daniela eAlbrecht-Eckardt, Michael eWeber, Sascha eBrunke, Ronny eMartin, Oliver eKurzai, Oliver eKurzai, Kerstin eHünniger   +10 more
doaj   +1 more source

Profiling the natural product-likeness of Latin American compound libraries [PDF]

Compound databases of natural products play a crucial role in drug discovery and development projects and have implications in other areas, such as food chemical research, ecology and metabolomics. Recently, we put together the first version of the Latin
Ann-Kathrin, Prinz, Alejandro, Gómez-García, Miguel Á., Chávez-Fumagalli, Oliver, Koch, Oscar M., Mosquera Martinez, Dionisio A., Olmedo, Marilia, Valli, Adriano D., Andricopulo, Haruna L., Barazorda-Ccahuana, Hoover A., Valencia Sánchez, Vanderlan da S., Bolzani, Johny R., Rodríguez Pérez, Daniel A., Acuña Jiménez, Marvin J., Núñez, Héctor F., Cortés Hernández, Pablo N., Solís, José L., Medina-Franco, William J., Zamora, Barazorda Ccahuana, Haruna Luz, Mosquera Martínez, Oscar Marino, Olmedo, Dionisio Antonio, Rodríguez Pérez, Johny Roberto, Prinz, Ann Kathrin, da Silva Bolzani, Vanderlan, Koch, Oliver, Acuña Jiménez, Daniel Alonso, Marilia Valli, Marilia, Zamora Ramírez, William J., Gómez García, Alejandro, Medina Franco, José Luis, Defini Andricopulo, Adriano, Valencia Sánchez, Hoover Albeiro, Solis González, Pablo Narciso, Cortés Hernández, Hector Fabio, Chávez Fumagalli, Miguel Angel, Núñez, Marvin José   +35 more
core   +3 more sources

Natural product fragment combination to performance-diverse pseudo-natural products

, 2021
Natural product structure and fragment-based compound development inspire pseudo-natural product design through different combinations of a given natural product fragment set to compound classes expected to be chemically and biologically diverse.
Pahl, A., Scheel, R., Strohmann, C., Sievers, S., Grigalunas, M., Gally, J., Waldmann, H., Foley, D., Burhop, A., Wild, N., Mantel, Y., Antonchick, A., Zinken, S., Sievers, Sonja, Waldmann, Herbert, Grigalunas, Michael, Mantel, Yannik, Strohmann, Carsten, Gally, José-Manuel, Scheel, Rebecca, Antonchick, Andrey P., Foley, Daniel J., Zinken, Sarah, Pahl, Axel, Burhop, Annina, Wild, Niklas   +25 more
core   +1 more source