Results 81 to 90 of about 7,942,931 (308)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Solvent derived artifacts in natural products chemistry
, 2009 Solvents play an important and critical role in natural product chemistry. They are mainly used during the extraction and purification of metabolites from a biological matrix. To a lesser extent, solvents are also used as reagents or catalysts to perform
Maltese, Federica +2 more
core
Aporphine Alkaloids from the Chinese Tree
Natural Product Communications, 2007 Three new oxygenated noraporphine alkaloids were isolated from the bark of the Chinese tree Neolitsea aurata var. paraciculata. The new compounds, (+)-11-methoxynorcassythicine, (+)-11-methoxynorneolitsine, (+)-11-methoxynorboldine, were isolated along ...
Malcolm S. Buchanan +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
, 2016 [EN] The chemical composition of essential oils from Satureja cuneifolia growing in east Spain was analyzed by GC, GC/MS. Forty-five compounds accounting for 99.1% of the total oil were identified.
Blazquez, M.A. +4 more
core
First Stereoselective Total Synthesis of (3)-De--methylbotryosphaeriodiplodin
Natural Product Communications, 2019 A simple and highly efficient first stereoselective total synthesis of a benzofused macrocyclic lactone, ( 3S,7R )-de- O -methylbotryosphaeriodiplodin has been accomplished utilizing Jacobson's kinetic resolution, Marouka asymmetric allylation, Stille ...
Jhillu S. Yadav +5 more
doaj +1 more source
Systems biology of fungal infection
Frontiers in Microbiology, 2012 Elucidation of pathogenicity mechanisms of the most important human pathogenic fungi, Aspergillus fumigatus and Candida albicans, has gained great interest in the light of the steadily increasing number of cases of invasive fungal infections.A key ...
Fabian eHorn +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Empowering natural product science with AI: leveraging multimodal data and knowledge graphs
Artificial intelligence (AI) is accelerating how we conduct science, from folding proteins with AlphaFold and summarizing literature findings with large language models, to annotating genomes and prioritizing newly generated molecules for screening using
Mejri, Yassine M +7 more
core +1 more source
Natural Product Reports, 2019 A comprehensive review of 1554 new MNPs, including numerous novel and bioactive compounds from marine bacteria.
Anthony R. Carroll +4 more
openaire +12 more sources