Results 81 to 90 of about 10,859,059 (267)

Elucidation of the protective effect of schisandrin C originating from Schisandra chinensis (Turcz.) Baill. against indomethacin-induced intestinal injury by combining network pharmacology, molecular docking, and experimental validation

Applied Biological Chemistry
Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), especially indomethacin, has severe adverse effects on the gastrointestinal system. Schisandra chinensis (Turcz.) Baill., an herbal medicine used to treat several gastrointestinal diseases ...
Son Hung Tran, Uyen Tran Tu Nguyen, Mi Ri Kim, Hee Ju Lee, Esther Youn, Won Young Bae, Suk Woo Kang, Won Kyu Kim, Ki Young Choi, Keunwan Park, Kyungsu Kang   +10 more
doaj   +1 more source

The Aspergillus fumigatus cell wall integrity signalling pathway: drug target, compensatory pathways and virulence

Frontiers in Microbiology, 2015
Aspergillus fumigatus is the most important airborne fungal pathogen, causing severe infections with invasive growth in immunocompromised patients. The fungal cell wall prevents the cell from lysing and protects the fungus against environmental stress ...
Vito eValiante, Juliane eMacheleidt, Martin eFöge, Axel A Brakhage   +3 more
doaj   +1 more source

Natural product-based amyloid inhibitors

Biochemical Pharmacology, 2017
Many chronic human diseases, including multiple neurodegenerative diseases, are associated with deleterious protein aggregates, also called protein amyloids. One common therapeutic strategy is to develop protein aggregation inhibitors that can slow down,
P. Velander, Ling-Tao Wu, Frances Henderson, Shijun Zhang, D. Bevan, Bin Xu   +5 more
semanticscholar   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function

Natural product reports (Print), 2017
Cytochrome P450 enzymes (P450s) are some of the most exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in steroid biosynthesis and drug metabolism in humans, P450s are key players in natural product biosynthetic ...
J. Rudolf, Chin-Yuan Chang, M. Ma, B. Shen   +3 more
semanticscholar   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Radicals in natural product synthesis

Chemical Society Reviews, 2018
Free radical intermediates have intrigued chemists since their discovery, and an evermore widespread appreciation for their unique reactivity has resulted in the employment of these species throughout the field of chemical synthesis. This is most evident
Kevin J Romero, Matthew S Galliher, D. Pratt, C. Stephenson   +3 more
semanticscholar   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source