Results 41 to 50 of about 27,977,136 (206)
Computational pharmaceutical materials science [PDF]
Journal of Cheminformatics, 2014 Pharmaceutical materials science addresses the physical solid-state properties of pharmaceutical products, such as solubility and stability of crystal structures. Especially the different properties of different polymorphs, salts and hydrates of an Active Pharmaceutical Ingredient (API) are of interest, although more recently the amorphous state has ...
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Heliyon, 2017 Aims: d-Serine (d-Ser), a co-agonist of N-methyl-d-aspartate receptor (NMDAR), is effective for treating schizophrenia. The present study investigated changes in plasma and striatal d-Ser levels in Sprague-Dawley (SD) rats after intraperitoneal d-Ser ...
Mayu Onozato +8 more
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Mechanism of Action and Target Identification: A Matter of Timing in Drug Discovery
iScience, 2020 Summary: Two opposing viewpoints are held regarding the need for understanding a drug's molecular target and mechanism of action. One extreme viewpoint is that it is unnecessary, because, after all, there are many beneficial drugs in use for which the ...
Ronald L. Davis
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iScience, 2021 Summary: The 2019 coronavirus disease (COVID-19) became a worldwide pandemic with currently no approved effective antiviral drug. Flux balance analysis (FBA) is an efficient method to analyze metabolic networks.
Ali Kishk +2 more
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Celebrating Women in the Pharmaceutical Sciences [PDF]
Molecular Pharmaceutics, 2021 Lynne S. Taylor +5 more
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R&D, Within and Between Patent Competition in the Pharmaceutical Industry [PDF]
, 2013 We analyse the consequences of the increasing complexity of R&D on within- and between-patent competition in the pharmaceutical industry. The intensity of competition is measured by jointly considering the timing from market launch to patent expiry, the
Magazzini, Laura +2 more
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Heliyon, 2018 Androgen biosynthesis in males occurs to a large extent in testicular Leydig cells. This study focused on the evaluation of three murine Leydig cell lines as potential screening tool to test xenobiotics interfering with gonadal androgen synthesis.
Roger T. Engeli +3 more
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, 2014 Plenaries and Special Presentations:Supriya Sharma, Acting Associate Assistant Deputy Minister, Health Canada: "Facing Tomorrow's Regulatory Challenges Today"Mick Bhatia, McMaster Stem Cell and Cancer Research Institute (SCC-RI): "Potential Applications
Canadian Society for Pharmaceutical Sciences (CSPS) +1 more
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Heliyon, 2018 Mesoporous silica with hexagonal type structure containing amine functional group was introduced. Firstly, aminopropyl hexagonal mesoporous silica was synthetized in a co-condensation process, via templating route of n-dodecylamine.
Fatemeh Farjadian +4 more
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Evaluation of incentives for R&D in the pharmaceutical industry with applications for neglected diseases [PDF]
, 2011 PhDThis thesis is concerned with the development of incentives for pharmaceutical R&D, specifically for neglected diseases. The following approaches are adopted.
Trushin, Eshref
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