Results 41 to 50 of about 28,995,883 (293)

Crystallization for Pharmaceutical and Food Science

Current Pharmaceutical Design, 2018

Hongxun, Hao, Qiuxiang, Yin, Jian, Zhong, Xichang, Wang   +3 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Computational pharmaceutical materials science [PDF]

Journal of Cheminformatics, 2014
Pharmaceutical materials science addresses the physical solid-state properties of pharmaceutical products, such as solubility and stability of crystal structures. Especially the different properties of different polymorphs, salts and hydrates of an Active Pharmaceutical Ingredient (API) are of interest, although more recently the amorphous state has ...
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Alteration in plasma and striatal levels of d-serine after d-serine administration with or without nicergoline: An in vivo microdialysis study

Heliyon, 2017
Aims: d-Serine (d-Ser), a co-agonist of N-methyl-d-aspartate receptor (NMDAR), is effective for treating schizophrenia. The present study investigated changes in plasma and striatal d-Ser levels in Sprague-Dawley (SD) rats after intraperitoneal d-Ser ...
Mayu Onozato, Hiromi Nakazawa, Katsuyuki Ishimaru, Chihiro Nagashima, Minori Fukumoto, Hitomi Hakariya, Tatsuya Sakamoto, Hideaki Ichiba, Takeshi Fukushima   +8 more
doaj   +1 more source

Mechanism of Action and Target Identification: A Matter of Timing in Drug Discovery

iScience, 2020
Summary: Two opposing viewpoints are held regarding the need for understanding a drug's molecular target and mechanism of action. One extreme viewpoint is that it is unnecessary, because, after all, there are many beneficial drugs in use for which the ...
Ronald L. Davis
doaj   +1 more source

DCcov: Repositioning of drugs and drug combinations for SARS-CoV-2 infected lung through constraint-based modeling

iScience, 2021
Summary: The 2019 coronavirus disease (COVID-19) became a worldwide pandemic with currently no approved effective antiviral drug. Flux balance analysis (FBA) is an efficient method to analyze metabolic networks.
Ali Kishk, Maria Pires Pacheco, Thomas Sauter   +2 more
doaj   +1 more source

Celebrating Women in the Pharmaceutical Sciences [PDF]

Molecular Pharmaceutics, 2021
Lynne S. Taylor, Christel A. S. Bergström, Afsaneh Lavasanifar, Feng Qian, Raj Suryanarayanan, Kristofer J. Thurecht   +5 more
openaire   +4 more sources

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

การประยุกต์ใช้พอลิเมอร์ที่มีรอยพิมพ์ประทับโมเลกุลสำหรับเลือกตรวจวัดและแยกสารไตรคลอโรอาซีติคในน้ำดื่ม

, 2007
Thesis (Ph.D., Pharmaceutical Science)--Prince of Songkla University ...
Wimon Intakong
core   +2 more sources