Results 61 to 70 of about 519,309 (312)

Methodological approaches to assessing digital maturity of logistics activities of pharmaceutical enterprises [PDF]

, 2023
The aim: development of methodological approaches to assessing the digital maturity of the logistics activity of a pharmaceutical enterprise and elaboration of the proposed methodology on the example of those domestic enterprises that have a developed ...
Ольга Вікторівна Olga Posilkina Посилкіна, Gladkova, Olga, Litvinova, Olena, Ольга Вячеславна Olga Gladkova Гладкова, Юлія Сергіївна Yuliia Bratishko Братішко, Олена Вячеславна Elena Litvinova Літвінова, Bratishko, Yuliia, Lisna, Anastasiіа, Posilkina, Olga, Анастасія Геннадіївна Anastasiіа Lisna Лісна   +9 more
core   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

PHARMACEUTICAL EVALUATION AND POST-MARKET SURVEILLANCE STUDY OF THREE BRANDS OF LISINOPRIL TABLETS IN SUDAN [PDF]

, 2021
Background: Lisinopril is a type of angiotensin-converting enzyme (ACE) inhibitor that used to treat high blood pressure (hypertension) in adults and children.
Alaa I. M. Ahmed, Gamil, Abdrhman Mahmoud, Magbool, Fatehalrahman F., Hassan, Anasseya HA, Ahmed, Alaa I. M., Fatehalrahman F. Magbool, Ali, Nagwa J. M., Anasseya HA Hassan, Nagwa J. M. Ali, Abdrhman Mahmoud Gamil   +9 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

R&D, Within and Between Patent Competition in the Pharmaceutical Industry [PDF]

, 2013
We analyse the consequences of the increasing complexity of R&D on within- and between-patent competition in the pharmaceutical industry. The intensity of competition is measured by jointly considering the timing from market launch to patent expiry, the
Magazzini, Laura, Pammolli, Fabio, Riccaboni, Massimo   +2 more
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

TO THE 90TH ANNIVERSARY OF BIRTHDAY OF PROFESSOR V.G. BELIKOV

Фармация и фармакология (Пятигорск), 2015
The article is devoted to basic life milestones of Professor, Doctor of Pharmaceutical Science, Honored Scientist of Russia V.G. Belikov, who made a great contribution to the development of domestic pharmaceutical education and science, more than 30 ...
B. V. Borovsky, M. V. Larsky, O. O. Frolova   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source