Results 61 to 70 of about 483,083 (302)
Pharmaceutical powder compressibility - a science-based approach [PDF]
, 2012 Background: The compressibility is a crucial property of powder formulations. For being able to compress a powder mixture to tablets with satisfactory pharmacocinetical behaviour, its compressibility has to be within a certain range.
Gentis, Nicolaos D.
core +1 more source
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
The Future of Pharmaceutical Manufacturing Sciences
Journal of Pharmaceutical Sciences, 2015 The entire pharmaceutical sector is in an urgent need of both innovative technological solutions and fundamental scientific work, enabling the production of highly engineered drug products. Commercial-scale manufacturing of complex drug delivery systems (DDSs) using the existing technologies is challenging.
Rantanen, Jukka, Khinast, Johannes
openaire +3 more sources
The Diffusion of Science-Driven Drug Discovery: Organizational Change in Pharmaceutical Research [PDF]
Recent work linking the adoption of key organizational practices to productivity raises an important question: if adoption increases productivity so dramatically, why does adoption across an industry take so long? This paper explores this question in the
Scott Stern +2 more
core
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
MCQs in Pharmaceutical Science and Technology
, 2010 Multiple choice questions (MCQs) are a key assessment and study tool in pharmacy courses throughout the world. MCQs in Pharmaceutical Science and Technology will serve as an invaluable resource for students and instructors in pharmaceutical science ...
Garg, S.
core
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Electron diffraction determines molecular absolute configuration in a pharmaceutical nanocrystal
Science, 2019 Dynamical refinement spots a difference For chiral molecules used in drugs, one isomer can have beneficial bioactivity, whereas the others are useless or even harmful.
P. Brázda, L. Palatinus, M. Babor
semanticscholar +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Modernizing Pharmaceutical Manufacturing: from Batch to Continuous Production
Journal of Pharmaceutical Innovation, 2015 The Food and Drug Administration (FDA) regulates pharmaceutical drug products to ensure a continuous supply of high-quality drugs in the USA. Continuous processing has a great deal of potential to address issues of agility, flexibility, cost, and ...
Sau Lee +8 more
semanticscholar +1 more source