Results 21 to 30 of about 303,590 (193)

From 'Kilo-Labor' to CarboGen [PDF]

, 2008
CarboGen Laboratories AG, a chemical service company focusing on the supply of experimental active pharmaceutical ingredients (API) in kilo quantities to research-based pharmaceutical companies started-up originally in the under-used 'Kilo Lab' of the ...
Beer, Dieter, Herzig, Thomas
core   +2 more sources

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Química orgánica para estudiantes de ingeniería de minas e ingeniería metalúrgica [PDF]

, 1994
Organic Chemistry is usually related to agricultural, pharmaceutical, alimentary, petroleum and derivate industries among others. However, the use of organic substances in other different industrial fields, like mining and metallurgy has increased and it
Maurelia Gómez, R.
core   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Fate of drugs during wastewater treatment [PDF]

, 2013
This is the post-print version of the final paper published in TrAC Trends in Analytical Chemistry. The published article is available from the link below.
Andrási, Bagnall, Baker, Baker, Barceló, Bedding, Bernhard, Brodin, Bruce Petrie, Buisson, Carbonaro, Chen, Chiaia-Hernandez, Chiu, Clara, Coelho, Duan, Elise Cartmell, Ewan J. McAdam, Ferrer, Galus, Gardner, Gaulke, Gomes, Gomes, Gomes, Gong, Grabic, Gracia-Lor, Gros, Gros, Grover, Guibaud, Gunnarsson, Göbel, Hashimoto, Helbling, Hignite, Ho, Hoigne, Huber, Huber, Huntscha, Hörsing, Ifelebuegu, Jelic, John N. Lester, Jones, Jones, Jones, Jones, Joss, Kasprzyk-Hordern, Khunjar, Kim, Kimura, Kosjek, Kreuzinger, Langford, Lishman, López-Serna, López-Serna, Marchese, Mark D. Scrimshaw, Matamoros, Maurer, McAdam, Metcalfe, Nakada, Nakada, Nieto, Ort, Ort, Petrie, Radjenovic, Radjenović, Reungoat, Robertson, Rosal, Samaras, Schaar, Sebők, Shen, Silva, Snyder, Snyder, Sumpter, Ternes, Ternes, Urase, Vader, Wagner, Wu, Wunder, Yang, Zearley, Zhao, Zorita, Zuloaga   +98 more
core   +2 more sources

Macromolecules Applied to Pharmaceutical Chemistry [PDF]

Molecules, 2005
Macromolecular and polymer science have evolved significantly over the past few years, with remarkable advances in many areas such as polymeric drugs, self-assembly systems, implant materials, drug delivery systems and controlled drug release.[...]
openaire   +2 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Revisiting the structure and chemistry of 3(5)-Substituted Pyrazoles [PDF]

, 2019
Pyrazoles are known as versatile scaffolds in organic synthesis and medicinal chemistry, often used as starting materials for the preparation of more complex heterocyclic systems with relevance in the pharmaceutical field.
Alam, Alina Secrieru, Alkorta, Andes, Anwar, Behr, Brown, Castillo, Catalan, Chauhan, Clark, Elguero, Elnagdi, Favre, Fichez, Hall, Horta, Katritzky, Katritzky, Kost, Kumar, Larina, Maria Lurdes Santos Cristiano, Mert, Minkin, Minkin, Mohamed, Nagy, Nimbalkar, Paul Michael O’Neill, Schofield, Simons, Szajda, Taylor, Zerbi   +34 more
core   +2 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source