Results 61 to 70 of about 555,640 (280)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Heliyon, 2016 Objectives: Microfluidic perfusion systems are used for assessing cell and tissue function while assuring cellular viability. Low perfusate flow rates, desired both for conserving reagents and for extending the number of channels and duration of ...
Austin Rountree +5 more
doaj +1 more source
Неперервна професійна освіта: теорія та практика, 2022 The relevance of the scientific topic is based on finding and solving the problems of selecting and improving the methodology of organization and conducting laboratory work in the teaching of pharmaceutical chemistry for students of the «Pharmacy ...
Galina Rizak
doaj +1 more source
Heliyon, 2020 Transferrin receptor protein 1 (TfR1) is an important molecule in anti-cancer therapy. Targeted delivery of such therapeutic compounds improves their cellular uptake and circulation time, thereby enhancing therapeutic efficacy.
Maha Ateeq AL-Refaei +2 more
doaj +1 more source
Tailored novel phosphonate-based hybrid materials by design for diverse applications [PDF]
, 2018 Hybrid materials are composed of an organic and an inorganic part, placed together in such a way that the final product has defined structures and properties.
Demadis, Konstantinos D.
core
Molecular Oncology, EarlyView.The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat +18 more
wiley +1 more source
Salmon cartilage proteoglycan promotes the healing process of Staphylococcus aureus-infected wound
Heliyon, 2018 Wound healing is the critical event for maintaining skin function and barrier. Inflammatory state in which a variety of cells are activated and accumulated is important for wound healing.
Shouhei Hirose +3 more
doaj +1 more source
, 2009 Identifying promising compounds from a vast collection of feasible compounds is an important and yet challenging problem in the pharmaceutical industry.
Mandal, Abhyuday +2 more
core +1 more source
Similarity-based data mining in files of two-dimensional chemical structures using fingerprint measures of molecular resemblance [PDF]
, 2011 This paper reviews the use of measures of intermolecular similarity for processing databases of chemical structures, which play an important role in the discovery of new drugs by the pharmaceutical industry.
Willett, P.
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source