Results 181 to 190 of about 145,026 (255)

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

A sustainable spectrofluorimetric method for ivabradine quantification based on erythrosin B quenching with quantum mechanical modeling and Box-Behnken design optimization. [PDF]

RSC Adv
Alqahtani AS, Abduljabbar MH, Alnemari RM, Althobaiti MM, Aldawsari MF, Al-Mutairi AA, Serag A, Almalki AH.   +7 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Spectrofluorimetric quantification of terconazole in pharmaceutical creams with comprehensive sustainability evaluation. [PDF]

BMC Chem
AlSalem HS, Alharbi SN, Mahmoud SA, Katamesh NS, Abdel-Lateef MA.   +4 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Heteroatom-doped MXene quantum dots for selective transition metal ion sensing: from atomic-level design to intelligent and deployable platforms. [PDF]

RSC Adv
Daoud E, Imad Najm B, Salim Waleed O, Shukla MB, M M R, Sasikumar Y, Sharma V, Aldulaimi A, Smaeilpour S.   +8 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Toward sustainable diagnostics for <i>Candida albicans</i>: the role of artificial intelligence in analytical chemistry from data processing to Python-based blueness and redness evaluation metrics. [PDF]

RSC Adv
Saleh AM, Hassan RYA, Badawey AM, Marzouk HM.   +3 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

A multihued sustainable appraisal of the electrochemical method for synchronized micro-estimation of the household drug Paracetamol with Aceclofenac or Dicyclomine. [PDF]

Sci Rep
Ahmed AR, Ragab MAA, Korany MA, Khashaba SA, Aboras SI.   +4 more
europepmc   +1 more source