Results 121 to 130 of about 492,973 (270)
Next SustainabilityThe present review aims to evaluate the potential of plant-derived saponins from Northeast India as sustainable alternatives to conventional synthetic surfactants.
Vani G. Viswam +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Highlights of the chemistry and pharmacological potential of 8-hydroxyquinoline: a review
Discover ChemistryFundamental heterocyclic molecules, quinolone and its analogs, especially 8-hydroxyquinoline, play a significant role in chemical synthesis. It has become clear that 8-hydroxyquinoline derivatives are incredibly adaptable molecules with a wide range of ...
Lian Ojotule Abah +9 more
doaj +1 more source
ChemistryBenzimidazole derivatives are a privileged family of heterocyclic compounds that have remarkable structural diversity and find various pharmacological and industrial applications.
Nuaman F. Alheety +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
A mechanistic perspective on the chemistry of biocatalytic desaturation
Tetrahedron ChemDesaturation is a fundamental transformation in both synthetic organic chemistry and essential biological processes. While chemical desaturation methods exhibit broad substrate tolerance, they often suffer from harsh reaction conditions and ...
Yueyue Zhu +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Green Chemistry Letters and ReviewsInitially, biobased polymers were replaced by synthetic plastics due to their superior properties. However, growing concerns about the toxicity of plastics have emerged following extensive global production and reliance on single-use plastics, which ...
Haitham Al-Madhagi
doaj +1 more source