Results 151 to 160 of about 189,065 (308)

Theiler’s virus infection provokes the overexpression of genes coding for the chemokine Ip10 (CXCL10) in SJL/J murine astrocytes, which can be inhibited by modulators of estrogen receptors

, 2017
© 2014, Journal of NeuroVirology, Inc. Theiler’s murine encephalomyelitis virus (TMEV) induces demyelination in susceptible strains of mice (SJL/J) through an immunopathological process that is mediated by CD4+ Th1 T cell.
García-Segura, Luis M., Cerciat, M., Sanz-Rodríguez, Francisco, Rubio, Nazario, Unkila, M., Arévalo, María Ángeles   +5 more
core   +1 more source

PARP inhibitor radiosensitization enhances anti-PD-L1 immunotherapy through stabilizing chemokine mRNA in small cell lung cancer

Nature Communications
Immunotherapy (IO) is an effective treatment for various cancers; however, the benefits are modest for small cell lung cancer (SCLC). The poor response of SCLC to anti-PD-1/PD-L1 IO is due in part to the lack of cytotoxic T cells because of limited ...
Xiaozhuo Ran, Bell Xi Wu, Venkatasubramanian Vidhyasagar, Lifang Song, Xu Zhang, Reese Jalal Ladak, Mona Teng, Wail Ba-alawi, Vivek Philip, Housheng H. He, Nahum Sonenberg, Benjamin H. Lok   +11 more
doaj   +1 more source

Sequential activation of conventional and plasmacytoid dendritic cells in autoimmune pancreatitis and systemic lupus erythematosus: similarities and dissimilarities

Frontiers in Immunology
Type 1 autoimmune pancreatitis (AIP) and systemic lupus erythematosus (SLE) are caused by type I IFNs secreted by plasmacytoid dendritic cells (pDCs).
Akane Hara, Tomohiro Watanabe, Kosuke Minaga, Ken Kamata, Warren Strober, Masatoshi Kudo   +5 more
doaj   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Molecular Functions and Drug Prediction of MMP1 and TGFBR2 in Nasopharyngeal Carcinoma

Journal of Clinical Laboratory Analysis, EarlyView.
MMP1 and TGFBR2 were validated by machine learning and external datasets as the candidate genes. Dexamethasone showed strong binding affinity to MMP1 (−7.72 kcal/mol) and TGFBR2 (−7.27 kcal/mol) in docking studies. Knockdown of MMP1 repressed the malignant phenotypes of NPC cells.
Feng Wang, Binbin Ge, Ming Li, Xiaochun Xia, Fuming Zhang, Pengqin Xu   +5 more
wiley   +1 more source

Study on Characteristics of Chemokine CXCL10 Gene Cloned from cDNA Expression Library of Ujumqin Sheep

, 2020
Chemokines were a major regulator of body's inflammatory and immune responses. In this study, the cDNA fragment of chemokine CXC ligand 10 (CXCL10) was cloned from the Ujumqin sheep ear marginal tissue cDNA expression library; the CXCL10 gene had ...
Y H Ma, P F Hu, W J Guan, N Lei, Q J Zhao, X C Li, X Y Lan   +6 more
core  

Chemokine expression and internalization by LSEC.

, 2015
(A) Chemokine mRNA expression was quantified in resting and TNF-α/IFN-γ activated LSEC in relation to GAPDH. (B) LSEC layer were incubated with fluorochrome-labeled CXCL10 or CXCL12 at 37°C or 4°C.
Katja Wechsung (751234), Michael Schumann (1906327), Alexander Scheffold (3394), Ulrike Erben (252359), Nils Kruse (348106), Katrin Neumann (331616), Anja A. Kühl (181163), Katja Klugewitz (348107)   +7 more
core   +1 more source

Dual role of CXCL10 in cancer progression: implications for immunotherapy and targeted treatment‎

Cancer Biology & Therapy
CXCL10 is a chemokine crucial for immune cell recruitment and inflammation modulation, especially ‎within the tumor microenvironment.‎ This review critically analyzes the underexplored role of CXCL10 in modulating ‎JAK/STAT, MAPK/ERK, and PI3K/Akt ...
Osama A. Madkhali, Sivakumar S. Moni, Yosif Almoshari, Fahad Y. Sabei, Awaji Y. Safhi   +4 more
doaj   +1 more source

Nail Lichen Planus in Children ‐ Epidemiology, Pathogenesis, Clinical Presentation, and Treatment

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail lichen planus (NLP) is a chronic inflammatory disorder that, while rare in children compared to adults, represents a significant cause of pediatric nail dystrophy that requires early recognition to prevent permanent scarring and nail loss.
Francesca Pampaloni, Matilde Iorizzo
wiley   +1 more source

The uterine-chemokine-brain axis: menstrual cycle-associated symptoms (MCAS) are in part mediated by CCL2, CCL5, CCL11, CXCL8 and CXCL10

, 2023
The uterine-chemokine-brain axis: menstrual cycle-associated symptoms (MCAS) are in part mediated by CCL2, CCL5, CCL11, CXCL8 and ...
C Roomruangwong (13330680), A F Carvalho (13330368), Michael Maes (13055841), S Sirivichayakul (13330596)   +3 more
core