Results 1 to 10 of about 12,027 (208)
Development of an interfering peptide M1-20 with potent anti-cancer effects by targeting FOXM1
Cell Death and Disease, 2023 Disrupting protein–protein interactions (PPIs) has emerged as a promising strategy for cancer drug development. Interfering peptides disrupting PPIs can be rationally designed based on the structures of natural sequences mediating these interactions ...
Huitong Bu +8 more
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Journal of Chemistry, 2017 Liquid speciation is important for reliable process design and optimization of gas-liquid absorption process. Liquid-phase speciation methods are currently available, although they involve tedious and time-consuming laboratory work. Raman spectroscopy is
Maths Halstensen +3 more
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t-SMILES: a fragment-based molecular representation framework for de novo ligand design
Nature CommunicationsEffective representation of molecules is a crucial factor affecting the performance of artificial intelligence models. This study introduces a flexible, fragment-based, multiscale molecular representation framework called t-SMILES (tree-based SMILES ...
Juan-Ni Wu +5 more
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Medical imaging-based companion diagnostics for solid tumors
EngMedicineHeterogeneity within the solid tumor microenvironment contributes to a poor prognosis and limited therapeutic responses. Companion diagnostics (CDx), a clinical technique that gives doctors vital biomarker information to enhance patient outcomes through ...
Rui Yin +6 more
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Uma proposta experimental para o ensino de MCR-ALS [PDF]
Química NovaChemometrics has gained significant importance in higher education and the job market, leading to an increasing number of teaching approaches for various chemometric tools.
Nathan S. Perrud +3 more
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A self-reactivated PdCu catalyst for aldehyde electro-oxidation with anodic hydrogen production
Nature CommunicationsThe low-potential aldehyde oxidation reaction can occur at low potential (~0 VRHE) and release H2 at the anode, enabling hydrogen production with less than one-tenth of the energy consumption required for water splitting.
Ming Yang +11 more
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Pulse potential mediated selectivity for the electrocatalytic oxidation of glycerol to glyceric acid
Nature CommunicationsPreventing the deactivation of noble metal-based catalysts due to self-oxidation and poisonous adsorption is a significant challenge in organic electro-oxidation.
Wei Chen +6 more
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Scientific ReportsNipah virus (NiV), with its significantly higher mortality rate compared to COVID-19, presents a looming threat as a potential next pandemic, particularly if constant mutations of NiV increase its transmissibility and transmission.
Siyun Yang, Supratik Kar
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Electroreductive alkylations of (hetero)arenes with carboxylic acids
Nature CommunicationsCarboxylic acids are widely available and generally inexpensive from abundant biomass feedstocks, and they are suitable and generic coupling partners in synthetic chemistry.
Bing Wang +3 more
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