Advances in Radiotherapy for Neoadjuvant Therapy of Stage III Non‐Small Cell Lung Cancer
Cancer Science, EarlyView.This review summarizes three neoadjuvant radiotherapy techniques for stage III NSCLC, highlighting SFRT's low‐toxicity dual immune‐tumor control benefits and radioimmunotherapy's superior pathological response to guide precise multimodal treatment. ABSTRACT This review aims to systematically summarize the mechanisms of action, clinical evolution, and ...
Qinrong Mao +5 more
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Cap-assisted photodynamic therapy for esophageal cancer: precise irradiation field control for tumor-confined treatment. [PDF]
EndoscopySugawara N +6 more
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Perioperative Durvalumab for Resectable NSCLC: Updated Outcomes for Japanese Patients in AEGEAN
Cancer Science, EarlyView.In prespecified exploratory analyses of Japanese patients with resectable NSCLC enrolled in the AEGEAN trial, perioperative durvalumab plus neoadjuvant chemotherapy demonstrated clinically meaningful improvements in the primary endpoints of EFS and pCR versus neoadjuvant chemotherapy alone.
Tetsuya Mitsudomi +16 more
wiley +1 more source
Cancer Science, EarlyView.INHBB secreted by colorectal cancer cells activates ACVR2B‐SMAD signaling to induce CD8+ T‐cell exhaustion and drive tumor progression. SB431542 blocks this oncogenic immune‐suppressive axis. ABSTRACT To investigate the expression pattern, biological functions and regulatory mechanisms of inhibin beta B (INHBB) in colorectal cancer (CRC), and to ...
Guanghui Liu +5 more
wiley +1 more source
Survival outcomes of postoperative radiotherapy and chemotherapy in early-stage cervical cancer: a Surveillance, Epidemiology, and End Results database-based stratified analysis. [PDF]
Transl Cancer ResWeng C, Wang Y, Chen W, Chen S, Zou L.
europepmc +1 more source
Cancer Science, EarlyView.In patients with esophageal squamous cell carcinoma receiving definitive radiotherapy combined with systemic therapy, posttreatment TP53 mutation clearance and ctDNA‐MRD negativity predict favorable outcomes, whereas persistent ctDNA signals indicate elevated relapse risk, supporting nucleosome‐ and MRD‐informed surveillance and risk‐stratification ...
Shutang Liu +9 more
wiley +1 more source
Cost-effectiveness of pembrolizumab plus chemoradiotherapy versus placebo plus chemoradiotherapy for high-risk locally advanced cervical cancer in Saudi Arabia: A model-based economic evaluation. [PDF]
Medicine (Baltimore)Almalki ZS +8 more
europepmc +1 more source
PABPC1 in Cancer: From a Translational Housekeeper to a Stress‐Responsive Regulatory Hub
Cancer Science, EarlyView.PABPC1 shifts from a translational housekeeper to a stress‐responsive oncogenic hub via phase separation, PTMs, and non‐coding RNA crosstalk, selectively driving oncogene translation and therapy resistance in cancer. ABSTRACT PABPC1, long recognized as a constitutive translational housekeeper, has emerged as a stress‐responsive translational ...
Cuiwei Zhang, Ye Zhu, Wenbo Long
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Analysis of real-world clinical outcomes of perioperative chemotherapy compared to preoperative chemoradiotherapy in esophagogastric adenocarcinoma. [PDF]
CancerOyenuga M +10 more
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Cancer Science, EarlyView.WJOG14120L NESSIE evaluated cisplatin, gemcitabine, and necitumumab (CGN) as second‐line therapy after ICI‐based treatment in 46 patients with advanced squamous NSCLC. ORR was 26.1%, DCR 87.0%, and median PFS 4.4 months. Although the predefined ORR threshold was not met, CGN showed modest antitumor activity with manageable toxicity.
Hiroshige Yoshioka +15 more
wiley +1 more source