Results 81 to 90 of about 168,140 (338)

Phase 1b/2a trial of the superoxide dismutase mimetic GC4419 to reduce chemoradiotherapy-induced oral mucositis in patients with oral cavity or oropharyngeal carcinoma [PDF]

, 2018
PURPOSE: To assess the safety of the superoxide dismutase mimetic GC4419 in combination with radiation and concurrent cisplatin for patients with oral cavity or oropharyngeal cancer (OCC) and to assess the potential of GC4419 to reduce severe oral ...
Adkins, Douglas, Agarwala, Sanjiv S, Allen, Bryan G, Anderson, Carryn M, Brill, Jeffrey M, Buatti, John M, Chen, Yuhchyau, Holmlund, Jon T, Lee, Christopher M, Mould, Diane R, Sonis, Stephen T, Sun, Wenqing, Venigalla, Madhavi L, Zhen, Weining   +13 more
core   +2 more sources

Late anastomotic complication after laparoscopic surgery for clinical stage I low rectal cancers located within 5 cm of the anal verge: Sub‐analysis of the ultimate trial

Annals of Gastroenterological Surgery, EarlyView.
Anastomotic stenosis and late fistula formation frequently emerge as secondary consequences of early AL, and represent significant complications linked to permanent stoma creation, often proving resistant to treatment. Intestinal prolapse is a characteristic anastomotic complication of ISR that can be caused by excessive intestinal mobilization.
Manabu Shimomura, Masanori Yoshimitsu, Yuichiro Tsukada, Hideki Ohdan, Jun Watanabe, Yosuke Fukunaga, Yasumitsu Hirano, Kazuhiro Sakamoto, Hiroki Hamamoto, Hisanaga Horie, Nobuhisa Matsuhashi, Yoshiaki Kuriu, Shuntaro Nagai, Madoka Hamada, Shinichi Yoshioka, Shinobu Ohnuma, Tamuro Hayama, Koki Otsuka, Yusuke Inoue, Kazuki Ueda, Yuji Toiyama, Satoshi Maruyama, Shigeki Yamaguchi, Keitaro Tanaka, Motoko Suzuki, Toshihiro Misumi, Takeshi Naitoh, Masahiko Watanabe, Masaaki Ito, Ultimate Trial Group   +29 more
wiley   +1 more source

Clinical factors of post-chemoradiotherapy as valuable indicators for pathological complete response in locally advanced rectal cancer

Clinics
OBJECTIVES: Pathological complete response has shown a better prognosis for patients with locally advanced rectal cancer after preoperative chemoradiotherapy.
Jianhong Peng, Junzhong Lin, Miaozhen Qiu, Xiaojun Wu, Zhenhai Lu, Gong Chen, Liren Li, Peirong Ding, Yuanhong Gao, Zhifan Zeng, Huizhong Zhang, Desen Wan, Zhizhong Pan   +12 more
doaj   +1 more source

Phase 1 Trial of Pembrolizumab Administered Concurrently With Chemoradiotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Nonrandomized Controlled Trial.

JAMA Oncology, 2020
Importance Consolidative programmed death ligand-1 (PD-L) inhibition after chemoradiotherapy improves overall survival and progression-free survival (PFS) for stage III non-small cell lung cancer (NSCLC) and requires safety evaluation for incorporation ...
S. Jabbour, A. Berman, R. Decker, Yong Lin, S. Feigenberg, S. Gettinger, C. Aggarwal, C. Langer, C. Simone, J. Bradley, J. Aisner, J. Malhotra   +11 more
semanticscholar   +1 more source

Prognostic factors for patients with esophageal cancer who achieve pathological complete response in the primary tumor after upfront chemotherapy or chemoradiotherapy

Annals of Gastroenterological Surgery, EarlyView.
Male gender and pathological lymph node metastasis are independent poor prognostic factors in patients with esophageal cancer who receive upfront treatment followed by surgery and achieved pathological complete response of the primary tumor. Among patients without pathological lymph node metastasis, the upfront chemotherapy group showed significantly ...
Masaaki Motoori, Koji Tanaka, Hiroshi Miyata, Makoto Yamasaki, Osamu Shiraishi, Atsushi Takeno, Tomoki Makino, Keijiro Sugimura, Takushi Yasuda, Yuichiro Doki   +9 more
wiley   +1 more source

Asthma caused by durvalumab after chemoradiotherapy in two patients with non‐small cell lung cancer

Respirology Case Reports, 2021
Durvalumab, an anti‐programmed cell death‐ligand 1 (PD‐L1) antibody, is currently used in the maintenance therapy for patients with stage III non‐small cell lung cancer after platinum‐based chemoradiotherapy.
Takehiro Uemura, Kensuke Fukumitsu, Ken Maeno, Satoshi Fukuda, Tomohiro Onuki, Yoshihiro Kanemitsu, Tetsuya Oguri, Akio Niimi, Toyoaki Hida   +8 more
doaj   +1 more source

Feasibility and Efficacy of Definitive Radiotherapy with 66 Gy and Concurrent Carboplatin-Paclitaxel Chemotherapy for Stage III Non-Small Cell Lung Cancer. [PDF]

, 2017
Purpose/Objectives : This study was conducted to assess the feasibility and efficacy of definitive radiotherapy (RT) with a total dose of 66 Gy and concurrent carboplatin-paclitaxel chemotherapy for patients (pts) with stage Ⅲ non-small celllung cancer ...
Asakawa, Isao, Hasegawa, Masatoshi, Hontsu, Shigeto, Inoue, Kazuya, Kimura, Hiroshi, Miura, Sachiko, Tamamoto, Tetsuro, Yoshimine, Tadashi   +7 more
core  

Prognostic value of PD-L1 expression on tumor cells combined with CD8+ TIL density in patients with locally advanced non-small cell lung cancer treated with concurrent chemoradiotherapy. [PDF]

, 2020
BACKGROUND/AIM:mmune checkpoint inhibition (CPI) has an increasing impact in the multimodal treatment of locally advanced non-small cell lung cancer (LA-NSCLC). Increasing evidence suggests treatment outcome depending on tumor cell PD-L1 expression.
Belka, Claus, Eze, Chukwuka, Gennen, Kathrin, Karin, Monika, Käsmann, Lukas, Manapov, Farkhad, Neumann, Jens, Orth, Michael, Reu, Simone, Roengvoraphoj, Olarn, Taugner, Julian, Tufman, Amanda   +11 more
core   +1 more source

Optimizing CIGB-300 intralesional delivery in locally advanced cervical cancer [PDF]

, 2015
Background:We conducted a phase 1 trial in patients with locally advanced cervical cancer by injecting 0.5 ml of the CK2-antagonist CIGB-300 in two different sites on tumours to assess tumour uptake, safety, pharmacodynamic activity and identify the ...
A Perera, A Prats, A Rodriguez-Ulloa, A Siddiqui-Jain, AM Solares, B E Acevedo, C A Casacó, C M Valenzuela, CA Naranjo, D F Alonso, F Piazza, I Baladrón, I García, I Hernández, J A Ancízar, JA Siegel, JL Soriano-García, JS Duncan, KA Ahmad, L A Torres, L González, L Molina, M A Coca, M R Sarduy, M Solares, P A López-Saura, P Therasse, R Gómez, R Prudent, RE Carter, S E Perea-Rodríguez, S Tawfic, SE Perea, SE Perea, SE Perea, V Reyes, Y M González, Y M Martínez, Y Perera, Y Perera, Y Perera, Y Perera   +41 more
core   +2 more sources

Impact of primary tumor clinicopathological factors on prognosis after hepatic resection for rectal liver metastases

Annals of Gastroenterological Surgery, EarlyView.
This retrospective study evaluates the prognostic factors in patients undergoing curative hepatic resection for rectal cancer liver metastases. It identifies lateral lymph node metastasis and perineural invasion as significant prognostic factors. Moreover, patients with these factors required nonsurgical treatment in the early postoperative period ...
Tomofumi Uotani, Takeshi Takamoto, Satoshi Nara, Daisuke Ban, Takahiro Mizui, Konosuke Moritani, Shunsuke Tsukamoto, Yukihide Kanemitsu, Tsutomu Fujii, Minoru Esaki   +9 more
wiley   +1 more source