Results 81 to 90 of about 97,795 (300)

Local Recurrence and Oncological Outcomes After Transanal Total Mesorectal Excision With Intersphincteric Resection for Lower Rectal Cancer: A Nationwide Multicenter Cohort Study (Ta‐Ta‐Mi Study)

Annals of Gastroenterological Surgery, EarlyView.
The 3‐year local recurrence (LR), recurrence‐free survival, and overall survival rates were 7.3%, 79.5%, and 98.1%, respectively. Multivariable analysis identified circumferential resection margin (CRM)/radial margin (RM) positivity as an independent risk factor for LR.
Kan Tanabe, Shinichiro Mori, Kenji Baba, Takeru Matsuda, Ichiro Takemasa, Koji Okabayashi, Chikayoshi Tani, Tatsuya Manabe, Yoshihiro Kakeji, Takao Ohtsuka, Seiichiro Yamamoto, Takeshi Naitoh, Ta‐Ta‐Mi Study Group Collaborative of the Japan Society of Laparoscopic Colorectal Surgery   +12 more
wiley   +1 more source

H&E to recurrence score: A step forward, but not yet a substitute for genomic testing

Translational Oncology
Shamai and colleagues developed a multimodal deep-learning model that predicts Oncotype DX recurrence scores from routine H&E slides and clinicopathological variables in hormone receptor‑positive, HER2‑negative early breast cancer.
Shiqiong Zhou, Qinghua Ke
doaj   +1 more source

Nasal Tuft Cell Markers Are Predictive of Overall Survival in Sinonasal Neuroendocrine and Sinonasal Undifferentiated Carcinomas

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Sinonasal neuroendocrine carcinoma (SNEC) and sinonasal undifferentiated carcinoma (SNUC) are rare aggressive malignancies with no established prognostic markers. Because features of POU2F3+ small cell lung carcinomas have been identified in both tumors, we evaluated immunostaining for POU2F3, a tuft cell transcription factor, and ...
Nikolina Dioufa, Ricardo V. Bruneto, Jennifer E. Douglas, Nithin D. Adappa, James N. Palmer, Noam A. Cohen, Michael A. Kohanski   +6 more
wiley   +1 more source

Direct Effects of Chemoradiotherapy following Esophagectomy

, 2011
<i>Background:</i> Esophageal cancer is a major cause of morbidity and mortality, but despite continuing research, few effective therapies have been identified.
V. Juhasz, T. Koszegi, L. Bogar, S. Marton, A. Papp, L. Cseke, P.O. Horvath, S. Ghosh   +7 more
core   +1 more source

Impact of chemoradiotherapy on the survival of unresectable locally advanced pancreatic cancer: a retrospective cohort analysis

, 2023
Background The role of chemoradiotherapy in unresectable locally advanced pancreatic cancer is still unclear. Methods Data from patients with unresectable locally advanced pancreatic cancer were extracted from the Surveillance, Epidemiology, and End ...
Zi-Meng Wang, Hong-Bin Ma, Yan Meng
core   +1 more source

Growth Differentiation Factor 15 as a Cerebrospinal Fluid Biomarker for the Diagnosis and Prognosis of Leptomeningeal Metastasis

Annals of Neurology, EarlyView.
Objective As leptomeningeal metastasis (LM) has a poor prognosis, reliable cerebrospinal fluid (CSF) diagnostic biomarkers are urgently needed. This study evaluated the diagnostic value of CSF growth differentiation factor 15 (GDF15) in LM from lung adenocarcinoma (LUAD) and breast cancer (BC).
Haoyu Ruan, Jie Li, Fuhai Wang, Lei Zhang, Jie Luo, Yuan Mu, Ting Wang, Yuqing Wu, Jingping Liu, Yunyun Ning, Xuan Deng, Ming Guan, Jian Xu   +12 more
wiley   +1 more source

Mechanism study of lncRNA RMRP regulating esophageal squamous cell carcinoma through miR-580-3p/ATP13A3 axis

Discover Oncology
Objective It is well-known that lncRNAs regulate energy metabolism in tumors. This study focused on the action of RMRP on esophageal squamous cell carcinoma (ESCC) cell proliferation, apoptosis, and glycolysis.
ZiRui Tan, ShengJie Luan, XiaoPeng Wang, WenPeng Jiao, Pu Jiang   +4 more
doaj   +1 more source

ANALYSIS OF HEMATOLOGIC, HEPATIC AND PANCREATIC TOXICITY DURING NEOADJUVANT CHEMORADIOTHERAPY IN PATIENTS WITH LOCALLY ADVANCED GASTRIC CANCER

Сибирский онкологический журнал, 2018
Purpose. We analyzed the frequency and severity of hematologic, hepatic and pancreatic toxicity during and after completion of neoadjuvant chemoradiotherapy in patients with gastric cancer.Material and methods.
V. Yu. Skoropad, D. D. Kudryavtsev, E. N. Anikina, M. V. Poluaktova, L. N. Titova   +4 more
doaj   +1 more source

O6-methylguanine-DNA Methyltransferase Promoter Methylation in Patients with Rectal Adenocarcinoma After Chemoradiotherapy Treatment: Clinical Implications [PDF]

, 2019
Brief Report 283Aims: To analyze the clinical relevance of O6-methylguanine-DNA methyltransferase in rectal adenocarcinoma treated with chemoradiotherapy followed by surgery.
Doello, Kevin, Perazzoli, Gloria, Cabeza Montilla, Laura, Jiménez Luna, Cristina, Oliver Esteve, Jaime Antonio, Ortiz Quesada, Raúl, Jaime Gómez-Millán, Raúl Ortiz, Cabeza, Laura, Ortiz, Raúl, Jimenez-Luna, Cristina, Cristina Jimenez-Luna, Gómez-Millán, Jaime, Oliver, Jaime A., Medina, Jose A., Jose A. Medina, Gloria Perazzoli, Jaime A. Oliver, Laura Cabeza, Kevin Doello   +19 more
core   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source