Results 91 to 100 of about 303,783 (310)

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

A real time chemotaxis assay unveils unique migratory profiles amongst different primary murine macrophages.

PLoS ONE, 2013
Chemotaxis assays are an invaluable tool for studying the biological activity of inflammatory mediators such as CC chemokines, which have been implicated in a wide range of chronic inflammatory diseases.
Asif J Iqbal, Daniel Regan-Komito, Ivy Christou, Gemma E White, Eileen McNeill, Amy Kenyon, Lewis Taylor, Theodore S Kapellos, Edward A Fisher, Keith M Channon, David R Greaves   +10 more
doaj   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

A high-throughput chemotaxis assay for assessing immunotoxicity using multiple human immune cell types

NAM Journal
New approach methodologies (NAMs) for immunotoxicity are critically needed for rapidly identifying immunotoxicants, filling gaps for data-poor chemicals, and reducing the number of vertebrate animals used in toxicity testing.
Drake W. Phelps, Nadia Barbo, Stephanie N. Caty, Joshua A. Harrill, Kimberly Slentz-Kesler   +4 more
doaj   +1 more source

A Chemotaxis Receptor Modulates Nodulation during the Azorhizobium caulinodans-Sesbania rostrata Symbiosis

, 2016
Azorhizobium caulinodans ORS571 is a free-living nitrogen-fixing bacterium which can induce nitrogen-fixing nodules both on the root and the stem of its legume host Sesbania rostrata.
Xie, ZH, Zhang, ZH, Elmerich, C, Liu, W, Jiang, N, Li, Y, Alexandre, G, Xie, ZH (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai, Peoples R China. zhxie@yic.ac.cn, Wu, HL   +8 more
core   +1 more source

Developing stochastic models for spatial inference: bacterial chemotaxis. [PDF]

, 2010
BACKGROUND: Biological systems are inherently inhomogeneous and spatial effects play a significant role in processes such as pattern formation. At the cellular level proteins are often localised either through static attachment or via a dynamic ...
Teo Yik-Ying, Yoonjoo Choi, Yu Y.-D., Yik-Ying Teo, Dalby Andrew R., Andrew R Dalby, Yu, Y.D., Dalby, A.R., Choi Yoonjoo, Dalby A.R., Yoon-Dong Yu, Choi Y., Choi, Y., Teo, Y.Y., Yu Yoon-Dong, Teo Y.-Y.   +15 more
core   +1 more source

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

Novel Pseudotaxis Mechanisms Improve Migration of Straight-Swimming Bacterial Mutants Through a Porous Environment

mBio, 2015
Bacterial locomotion driven by flagella is given directionality by the chemotaxis signal transduction network. In the classic plate assays of migration in porous motility agar, efficient motility is compromised in chemotaxis mutants of diverse bacteria ...
Bitan Mohari, Nicholas A. Licata, David T. Kysela, Peter M. Merritt, Suchetana Mukhopadhay, Yves V. Brun, Sima Setayeshgar, Clay Fuqua   +7 more
doaj   +1 more source

Dynamic localization of chemotaxis proteins in Bacillus subtilis

, 2010
Understanding the subcellular localization of a protein or protein clusters is helpful to conceive the function of the proteins or the mechanism of the pathway involving these proteins.
Wu, Kang
core  

Chemotaxis can take plant-parasitic nematodes to the source of a chemo-attractant via the shortest possible routes

, 2010
It has long been recognized that chemotaxis is the primary means by which nematodes locate host plants. Nonetheless, chemotaxis has received scant attention.
Curtis, R. H. C., Powers, S. J., Reynolds, A. M., Dutta, T. K., Andy M. Reynolds, Brian R. Kerry, Tushar K. Dutta, Rosane H. C. Curtis, Stephen J. Powers, Kerry, B. R., Gaur, H. S., Hari S. Gaur   +11 more
core   +1 more source