Results 181 to 190 of about 280,831 (264)

Local Ras/actin signaling orients individual pseudopods in shallow gradients. [PDF]

Proc Natl Acad Sci U S A
van Haastert PJM.
europepmc   +1 more source

Managing the meniscus Part 2: Traumatic tear patterns, biologic augmentation, transplantation, innovation and future research

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Acute, traumatic meniscus tears are common and should be repaired whenever possible. However, the biological age of the patient, along with the specific tear morphology, may significantly influence the selection of the repair technique, expected clinical outcomes and the postoperative rehabilitation protocol.
Armin Runer, Matthew P. Kolevar, Ehab M. Nazzal, Jonathan D. Hughes, Sebastian Kopf, Aaron J. Krych, Michael T. Hirschmann, Robert F. LaPrade, Alan Getgood, Tim Spalding, Robert Prill, Maria Tuca, Matthieu Ollivier, Sebastian Siebenlist, Sachin Tapasvi, Volker Musahl   +15 more
wiley   +1 more source

Chemotaxis kinase CheA is regulated by modulating interdomain interactions. [PDF]

Biophys J
Lu-Diaz KW, Huang J, Chen J, Fejzo J, Thompson LK.   +4 more
europepmc   +1 more source

Myeloid Focal Adhesion Kinase Promotes Macrophage Accumulation but Does Not Alter Tumor Progression in Hepatocellular Carcinoma

Molecular Carcinogenesis, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) develops within an immunologically complex tumor microenvironment that is heavily shaped by infiltrating myeloid cells. Immune‐based treatment strategies such as atezolizumab plus bevacizumab have shown promising therapeutic benefits, but patients do not experience durable responses.
Eugene Ham, Kyle Boedeker, Claudia Rose Keating, Ruisong Ye, Frankie Montalbano, Sophia Mankaruse, Xianzhong Ding, Jonathan P. Rennhack, Wei Qiu   +8 more
wiley   +1 more source

A role for PaxB in regulating blebbing: experimental insights and theoretical perspectives from Dictyostelium discoideum. [PDF]

BMC Mol Cell Biol
Santiago Z, Wey B, Sewwandi de Silva SHD, Reznik J, Siby L, Asante-Asamani E, Brazil D.   +6 more
europepmc   +1 more source

Proteomic Signatures of Ectopic Fat Distribution: Tissue‐Specific Drivers and Clinical Implications

Med Research, EarlyView.
Integration of plasma proteomics and multi‐organ MRI in 666 UK Biobank participants, combined with a knockoff‐based causal inference and machine learning framework, reveals organ‐specific drivers of ectopic fat: PLA2G1B (pancreas), ERBB2/IGFBP2 (liver), CA14 (muscle), and NCAM2/TNFRSF10B (pericardium). These drivers engage distinct pathways (e.g., PI3K‐
Bing Zhang, Fen Yang, Xingji Lian, Jie He, Shuijin Huang, Mingjuan Fan, Yin Liang, Jiaqiang Huang, LongYan Yin, Hong Wang   +9 more
wiley   +1 more source

Propulsion-enhanced chemotaxis drives bifunctional enzymatic nanorobots deep into tumors. [PDF]

Natl Sci Rev
Li S, Nie G, Zhao Y.
europepmc   +1 more source

Natural Killer Subset Changes and Vascular Endothelial Growth Factor‐A Plasma Profile in Progressive Supranuclear Palsy: The NKscape Study

Movement Disorders, EarlyView.
Abstract Background Emerging evidence implicates neuroinflammation in progressive supranuclear palsy (PSP) pathophysiology, with elevated cyto‐chemokines suggesting natural killer (NK) cell involvement. Methods We characterized peripheral NK in PSP (N = 11) versus Parkinson's disease (PD, N = 10) and healthy controls (HC, N = 8) at both ...
Marina Picillo, Cristina Basile, Francesco Montella, Valentina Lopardo, Mariangela Orlando, Roberta Tarallo, Domenico Palumbo, Viola Melone, Maria Francesca Tepedino, Paolo Barone, Annibale Alessandro Puca, Elena Ciaglia   +11 more
wiley   +1 more source

Transcriptome, metabolome, and inflammatory and oxidative properties of <i>Clostridium butyricum</i> CB1002 clinical strain and its isogenic mutant Δ<i>hbd</i>. [PDF]

Appl Environ Microbiol
Nicolas L, Mesa V, Ferraris L, Delannoy J, Cokelaer T, Chollet C, Castelli F, Zerrad-Saadi A, Barbut F, Aires J.   +9 more
europepmc   +1 more source

Solvability and Boundedness in Chemotaxis‐Consumption Models With Oppositely Acting Nonlocal Sources

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT In this paper, we investigate a chemotaxis system featuring a class of external source terms that incorporate both local and nonlocal growth as well as dampening effects. The model describes the evolution of a cell density u$$ u $$, which migrates in response to a chemical signal v$$ v $$, within an impermeable habitat.
Rafael Díaz Fuentes, Fatma Gamze Düzgün, Silvia Frassu, Giuseppe Viglialoro   +3 more
wiley   +1 more source