Results 181 to 190 of about 350,788 (241)

Harnessing Organometallic Au(III) Complexes as Precision Scaffolds for Next‐Generation Therapeutic and Imaging Agents

open access: yesChemBioChem, EarlyView.
Cyclometalated gold(III) complexes offer a versatile platform for selective biological interactions, including cysteine arylation, redox modulation, and enzyme inhibition. This review explores their roles in anticancer, antimicrobial, and protein modification strategies, highlighting their ability to disrupt metabolic pathways, modulate aquaporins, and
Sophie R. Thomas, Riccardo Bonsignore
wiley   +1 more source

Synthesis and Evaluation of Trehalose‐Based Mertansine Warheads for BCG Delivery of Anti‐Cancer Agents

open access: yesChemBioChem, Accepted Article.
Non‐muscle invasive bladder cancer (NMIBC) accounts for 75% of bladder cancer cases, with Bacillus Calmette‐Guérin (BCG) immunotherapy as the gold standard for high‐risk patients. BCG elicits a robust immune response but is limited by adverse effects and resistance. To enhance its efficacy, we developed a trehalose‐based conjugation strategy, tethering
Michael Grimmeisen   +10 more
wiley   +1 more source

Advances in Organic Porous Polymeric‐Supported Photothermal Phase Change Materials

open access: yesCarbon Energy, EarlyView.
This article introduces the latest progress in the preparation and application of PTPCMs based on porous polymer carriers, evaluates the influence of different porous polymer materials on the performance of PTPCMs, elucidates the mechanisms of photothermal conversion and heat storage, and discusses future research challenges and possible solutions ...
Fulai Zhao   +6 more
wiley   +1 more source

The expression of PRMT5 is associated with postoperative chemotherapeutic outcome in colon cancer. [PDF]

open access: yesBMC Cancer
Lu L   +9 more
europepmc   +1 more source

Deciphering the transcriptomic landscape of early HR+/HER2− breast cancer in very young women

open access: yes
Cancer Communications, EarlyView.
Iris Garrido‐Cano   +15 more
wiley   +1 more source

Recent Cutting‐Edge Technologies for the Delivery of Peptide Nucleic Acid

open access: yesChemistry – A European Journal, EarlyView.
This review provides an overview of PNA cellular delivery methods, starting with traditional peptide‐based systems and progressing to advanced approaches using nanoparticles, liposomes, and calixarene. It highlights how these innovative strategies have opened the way for more effective and efficient PNA delivery, ultimately enhancing the potential for ...
Concetta Avitabile   +4 more
wiley   +1 more source

Balancing Antigen Loading on Gold Nanoparticles: Implications for Future Cancer Vaccine Strategies

open access: yesChemistry – A European Journal, EarlyView.
The synthesis of multicomponent cancer vaccines on AuNP carriers could be rationalized by the simultaneous functionalization of the antigen and immunomodulator components on the same particles. Immunization with a “diluted” amount of MUC1‐functionalized AuNPs is still capable of eliciting a strong immune response.
Mattia Ghirardello   +8 more
wiley   +1 more source

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