Results 121 to 130 of about 56,264 (258)

Phase II study of pregabalin for the prevention of chemotherapy induced nausea and vomiting

O Mundo da Saúde
To evaluate the role of pregabalin in the protection of chemotherapy-induced nausea and vomiting, we performed a phase II randomized, double-blind, placebo-controlled trial to investigate whether pregabalin could improve the complete control of nausea ...
Carla Santos Rossi Paniquar, Auro del Giglio, Alayne Magalhães Trindade Domingues Yamada, Felipe José Silva Melo Cruz   +3 more
doaj   +1 more source

Efficacy, safety, and relapse outcomes of MAPK inhibitors in pediatric Langerhans cell histiocytosis: A real‐world study

International Journal of Cancer, Volume 158, Issue 10, Page 2674-2683, 15 May 2026.
What's new? Mitogen‐activated protein kinase (MAPK) inhibitors are promising treatments for pediatric Langerhans cell histiocytosis (LCH), a rare heterogeneous neoplasm that often affects multiple organ systems. Which MAPK inhibitors are most effective against LCH remains uncertain.
Xue Tang, Jing‐jing Sun, Zhi Wan, Xiao‐yu Jing, Xia Guo, Ju Gao   +5 more
wiley   +1 more source

Model‐informed precision dosing of carboplatin in cancer patients by leveraging myelosuppression data from electronic health records

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1457-1472, May 2026.
Abstract Aims This study aimed to develop and validate a population pharmacokinetic‐pharmacodynamic (pop‐PK‐PD) model to describe carboplatin‐induced myelosuppression in cancer patients and support dose individualization. Methods Data from 580 cancer patients treated with carboplatin at Amsterdam UMC between 2019 and 2022 were used for model ...
Alessandro De Carlo, Elena Maria Tosca, Mirjam Crul, Tim Schutte, Lia van Zuijlen, Idris Bahce, Medhat M. Said, Jan Buter, Harmen Huls, Paolo Magni, Imke Bartelink   +10 more
wiley   +1 more source

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1287-1308, May 2026.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Effect of neiguan acupoint pressure on improving chemotherapy⁃induced nausea and vomiting in cancer patients:a Meta analysis

Huli yanjiu, 2020
ObjectiveTo systematically evaluate the clinical effect of neiguan acupoint pressure on improving chemotherapy-induced nausea and vomiting in cancer patients.MethodThe RCTs related to effect of neiguan acupoint pressure on improving chemotherapy-induced ...
CHEN Feng, YANG Xue, LIU Li, LI Le, WANG Yiping   +4 more
doaj  

Impact of Physical Frailty on Early Intolerance to CAPOX Chemotherapy in Patients With Colon, Rectal, and Gastric Cancer

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Patients with gastrointestinal cancer often present reduction in functional capacity and develop frailty, which increases the risk of chemotherapy intolerance. We investigated whether physical frailty is associated with early intolerance to CAPOX (capecitabine+oxaliplatin) in patients with colon, rectal, or gastric cancer.
Isabella Pellegrini Grama Pereira Lima, Nicolle Martins Carrozzi, Talita Oliveira Silva, Karina Almeida de Brunheroti, Joyce Lucchesi, Andréia Cristina Dalbello Rissati, Lucinea Valério de Almeida Castro, Maria Carolina Santos Mendes, José Barreto Campello Carvalheira, Lígia M. Antunes‐Correa   +9 more
wiley   +1 more source

Efficacy of Hepatic Artery Infusion Chemotherapy Combined With Regorafenib and Sintilimab Versus Regorafenib Alone in MSS/pMMR Colorectal Cancer Liver Metastases After Second‐Line Treatment Failure

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Microsatellite stable/proficient mismatch repair (MSS/pMMR) colorectal cancer liver metastases (CRCLM) have limited treatment options after failure of second‐line systemic therapies. Hepatic artery infusion chemotherapy (HAIC) combined with targeted therapy and immunotherapy may offer improved outcomes.
Ran You, Qingyu Xu, Lixing Wang, Bin Leng, Chendong Wang, Zeyu Yu, Ya Lu, Lingfeng Diao, Yi Lu, Guowen Yin   +9 more
wiley   +1 more source

Chemotherapy-induced nausea and vomiting: exploring patients’ subjective experience

Journal of Multidisciplinary Healthcare, 2016
Noor Salihah,1 Nik Mazlan,2 Pei Lin Lua3 1Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Kampus Gong Badak, Terengganu, 2Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, Pahang, 3Community Health Research
Salihah N, Mazlan N, Lua PL
doaj  

A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse. [PDF]

, 2000
A randomized, multicentre, open-label, phase II study compared temozolomide (TMZ), an oral second-generation alkylating agent, and procarbazine (PCB) in 225 patients with glioblastoma multiforme at first relapse.
Albright, RE, Brada, M, Bruner, J, Fink, K, Fredericks, R, Friedman, H, Glantz, M, Greenberg, H, Hohl, RJ, Levin, VA, Olson, J, Osoba, D, Phillips, P, Prados, MD, Rampling, R, Selker, RG, Shapiro, W, Spence, A, Vick, NA, Yue, N, Yung, WK, Zaknoen, S   +21 more
core  

The Clinical Benefits of Nutritional Supplementation Across the Chemotherapy Journey in Cancer Patients: A Multicenter Prospective Cohort Study

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Purpose This study aimed to explore the clinical benefits of receiving nutritional supplementation (NS) throughout the whole course of chemotherapy. Methods This multicenter prospective cohort study totally included 251 cancer patients requiring nutritional support and scheduled for chemotherapy.
Jia‐Xin Huang, Si‐Wei Xie, Hui‐Min Qu, Zhi‐Gang Feng, Xin‐Yi Wang, Jun Zhao, Quan‐Fu Li, Ying Jiang, Feng Chen, Jun Li, Shun‐Chun Yao, Ming‐Hui Zhang, Xian Shen, Xiao‐Dong Chen, Ning Li, Xi Zhang, Le Tian, Min Yang, Meng Tang, Chen‐Xin Song, Bao‐Hua Zou, Sheng‐Ling Qin, Rong Qin, Ming‐Hua Cong   +23 more
wiley   +1 more source