Results 141 to 150 of about 56,264 (258)
Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang +6 more
wiley +1 more source
Humphrey Center News: Spring 1991 v. 6, no. 1 [PDF]
Newsletter of the Hubert H.
Anthony, Richard P. +1 more
core
Our pilot clinical study in laryngeal transplantation achieved divergent outcomes: two cases maintained functional speech/swallowing with around 2 year graft survival and have been ongoing, while two succumbed to sepsis (10mo) and hemorrhagic recurrence (11mo).
Zheng Jiang +9 more
wiley +1 more source
Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management
The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang +12 more
wiley +1 more source
For downloading the full-text of this article please click here. Background and Objective: Nausea and vomiting are two common and disturbing adverse effect of chemotherapy.
Shaghayegh Kamian, Morteza Tabatabaeefar
doaj
Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli +4 more
wiley +1 more source
Background Chemotherapy-induced nausea and vomiting is a common adverse event of cancer treatments. Despite prophylactic antiemetic treatment, nausea remains a particular problem. We aimed to identify risk factors and clarify the usefulness of olanzapine
Suguru Kojima +17 more
doaj +1 more source
ABSTRACT The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety, and systematizing treatment, employing evidence‐based medicine techniques and aimed at improvement of the outcomes.
Yoshiaki Kinoshita +116 more
wiley +1 more source
ABSTRACT Familial adenomatous polyposis (FAP) is a hereditary condition marked by the growth of hundreds to thousands of adenomatous polyps in the colon and rectum, significantly elevating the risk of colorectal cancer (CRC) if left untreated. Caused by pathogenic variants in the APC gene, FAP is typically identified in adolescence, often leading to ...
John Gásdal Karstensen
wiley +1 more source

