Results 91 to 100 of about 3,981,458 (213)
British Journal of Haematology, EarlyView.Baseline immunophenotype and gene expression predict suitability for salvage nivolumab in patients with relapsed/refractory haematological malignancy. Summary Allogeneic haematopoietic stem cell transplantation (alloHSCT) relies on donor‐derived T cells to mediate the graft‐versus‐tumour (GVT) effect, but relapse may result from impaired immune ...
Trung Q. Ngo +7 more
wiley +1 more source
, 2021 Chemotherapy-induced thrombocytopenia (CIT) contributes to treatment dose delay and/or modification, often resulting in poorer survival and disease progression. We explored the incidence and clinical consequences of CIT among metastatic colorectal cancer
Shaw, Jaime L. +13 more
core +1 more source
Obinutuzumab-induced severe acute thrombocytopenia: a case report and literature review
Frontiers in ImmunologyObinutuzumab is a humanized type II anti-CD20 monoclonal antibody that is widely used in B-cell lymphomas including follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL).
Kun Kou, Qiaolin Zhou, Lijun Du, Fang Xu
doaj +1 more source
A guide to transcriptional cyclin‐dependent kinases in cancer
The FEBS Journal, EarlyView.Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin +2 more
wiley +1 more source
, 2019 Supplemental material, Supplemental_Table_1 for Effects of Shen Cao Granules on Chemotherapy-Induced Thrombocytopenia in Gastrointestinal Cancer Patients: A Randomized Controlled Trial by Chunfeng Yu, Wei Liu, Yuejun Mu, Aihua Hou and Yin Li in ...
Yuejun Mu (6337496) +4 more
core +1 more source
Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy
Immunology &Cell Biology, EarlyView.IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley +1 more source
Immunology, EarlyView.LW‐9, a peptide derived from Phoneutria nigriventer venom, enhances antitumor immunity in a murine breast cancer model by remodelling the tumour microenvironment. Treatment reduces PD‐L1 expression while increasing CD3+ and GITR+ T‐cell infiltration, resulting in delayed tumour progression, particularly when combined with doxorubicin.
Ingrid Mayara Cavalcante Trevisan +7 more
wiley +1 more source
Viruses, Periodontitis, and Systemic Diseases
Journal of Periodontal Research, EarlyView.This narrative review aimed to summarize current evidence on the viral involvement in periodontitis and its relevance for systemic diseases. The oral cavity acts as an active viral reservoir and dissemination platform, where virus–microbiome interactions may promote dysbiosis, periodontitis progression, and systemic inflammatory effects, while the ...
Kim Natalie Solte +2 more
wiley +1 more source
, 2012 569 Background: Chemotherapy-induced splenomegaly is a relatively known treatment complication, where the clinical sequale of hypersplenism is persistent thrombocytopenia due to splenic sequestration.
Jonathan Phillips +5 more
core +1 more source
Use of in vitro human keratinocyte models to study the effect of cooling on chemotherapy drug-induced cytotoxicity [PDF]
, 2014 A highly distressing side-effect of cancer chemotherapy is chemotherapy-induced alopecia (CIA). Scalp cooling remains the only treatment for CIA, yet there is no experimental evidence to support the cytoprotective capacity of cooling. We have established
van den Hurk, Corina J. +6 more
core +1 more source