Results 171 to 180 of about 3,981,458 (213)

Chemotherapy Induced Thrombocytopenia in Pediatric Oncology

Critical Reviews in Oncology/Hematology, 2016
Thrombocytopenia has long been recognized as a significant problem of cancer therapy, but there is still lack of consensus about the optimal approach to prophylaxis and/or treatment of this important complication. In pediatric oncology, since there are very few studies dedicated to this problem, the knowledge gap is even larger and no final conclusions
Samvel Danelyan, Gevorg Tamamyan, Michele P Lambert   +2 more
exaly   +3 more sources

Romiplostim versus Placebo for Chemotherapy-Induced Thrombocytopenia

New England Journal of Medicine
Chemotherapy-induced thrombocytopenia (CIT) is a common complication of chemotherapy that is associated with bleeding, reduced relative dose intensity, and potentially worse outcomes. No widely available therapies are approved for CIT.We conducted a phase 3, international, double-blind, randomized, placebo-controlled trial involving patients with ...
Hanny Al-Samkari, César Muñoz, Çağlayan Geredeli, Ippokratis Korantzis, Beatriz González Astorga, Cagatay Arslan, Johnny Francisco Cordeiro Camargo, Florian Scotté, Giuliano Borges, Kejia Wang, Melissa Eisen, David J. Kuter, Gerald A. Soff   +12 more
openaire   +3 more sources

The effect of lithium carbonate on chemotherapy‐induced neutropenia and thrombocytopenia

American Journal of Hematology, 1984
AbstractLithium carbonate ameliorates neutropenia associated with cancer chemotherapy. The effect of lithium on platelet suppression has not, however, been well established. In the present study, five patients with ovarian carcinoma received daily lithium during alternate cycles of treatment with hexamethylmelamine, cyclophosphamide, adriamycin, and ...
C M, Richman, M M, Makii, P A, Weiser, A L, Herbst   +3 more
openaire   +2 more sources

Romiplostim in a Case Series of Chemotherapy-Induced Thrombocytopenia

Blood, 2011
Abstract 1170 Thrombocytopenia is a common effect of cytotoxic chemotherapy regimens in cancer patients, often necessitating reduction or delay in subsequent cycles. While the thrombocytopenia typically resolves with time, a subset of patients (pts) with chemotherapy-induced thrombocytopenia (CIT) have prolonged thrombocytopenia, of ...
Rekha Parameswaran, Gerald A. Soff
openaire   +1 more source

Interleukin 3 in the treatment of chemotherapy induced thrombocytopenia.

Oncology Reports, 1998
We enrolled 19 cancer patients (11 females, 8 males) with thrombocytopenia after standard dose of chemotherapy to receive IL3 10 mg/kg/day s.c. until hematologic recovery. Therapeutic success was obtained in 69.6% of cycles; a major response in 39.3% and a minor response in 30.3% of cycles. We obtained the best results in case of platelet count
V, Leonardi, M, Danova, G, Fincato, S, Palmeri   +3 more
openaire   +2 more sources

Impact of Romiplostim on Overall Survival in Chemotherapy Induced Thrombocytopenia

Blood, 2023
BACKGROUND Romiplostim, a thrombopoietin receptor agonist, has been shown in a phase 2 trial to increase platelet count and facilitate chemotherapy administration in the setting of chemotherapy induced thrombocytopenia (CIT).
Cy R Wilkins, Jeffrey I. Zwicker, Andriy Derkach, Miranda Burge   +3 more
openaire   +1 more source

A second chance for avatrombopag in chemotherapy‐induced thrombocytopenia

British Journal of Haematology
Chemotherapy‐induced thrombocytopenia (CIT) remains a common complication of cancer therapy with no approved available treatments in most of the world. Although a prior clinical trial of avatrombopag for CIT did not meet its primary end‐point, a report from Galamaga and colleagues raises prospects for a second chance for avatrombopag in CIT ...
Hanny Al‐Samkari, Donald C. Moore
openaire   +2 more sources

The Protective Effect of Sweet Potato Root Tuber on Chemotherapy‐Induced Thrombocytopenia

Molecular Nutrition & Food Research, 2022
ScopeSweet potato (Ipomoea batatas L.) is one of the leading crops worldwide, containing high nutritional components such as fiber and polyphenols. Root tuber of Simon 1 (SIMON), a cultivar of sweet potato, is a folk food in China with a hemostasis function but lacking experimental data support.Methods and resultsNow the protective effect of SIMON on ...
Zi‐Heng Qi, Xiao‐Jun Yan, Yang‐Yang Liu, Xia Hou, Zhu Zhao, Yan‐Yan Zhu, Ying‐Jie He, Zhao‐Jie Wang, Hong‐Jun Yang, Zhong‐Yuan Na, Yun‐Li Zhao, Xiao‐Dong Luo   +11 more
openaire   +2 more sources

The use of second-generation thrombopoietic agents for chemotherapy-induced thrombocytopenia

Current Opinion in Oncology, 2008
This review summarizes the history of the development of thrombopoietic agents and discusses their potential use in chemotherapy-induced thrombocytopenia.A new generation of thrombopoietic agents have had preliminary success in the treatment of thrombocytopenia. The initial thrombopoietic agents were recombinant and pegylated human megakaryocyte growth
Benjamin, Levy, Jon E, Arnason, James B, Bussel   +2 more
openaire   +2 more sources

Nanocurcumin as a novel stimulator of megakaryopoiesis that ameliorates chemotherapy-induced thrombocytopenia in mice

Life Sciences, 2020
Platelet production improvement can resolve concerns about the limitations of external platelet supply and platelet transfusion in thrombocytopenia patients. To this end, scientists encourage to induce the generation of megakaryocyte and platelet. Curcumin is a safe ingredient of turmeric that affects various cellular pathways.
Seyedeh Sahar, Mortazavi Farsani, Majid, Sadeghizadeh, Mohammad Ali, Gholampour, Zohreh, Safari, Farhood, Najafi   +4 more
openaire   +2 more sources