Results 281 to 290 of about 2,075,344 (349)

Photosensitizing Lipid Nanoparticles for Ferroptosis‐Enhanced Photodynamic Cancer Therapy via GPX4 Silencing

Advanced Healthcare Materials, EarlyView.
Photosensitizing lipid nanoparticles (PLNPs) are engineered by incorporating cholesterol–PEG–pheophorbide a into MC3‐based LNPs and encapsulating GPX4‐targeting siRNA. Upon light activation, PLNPs generate reactive oxygen species (ROS) while silencing GPX4 to induce ferroptosis.
Ga‐Hyun Bae, Seungyong Shin, Joo Dong Park, Eun‐Young Koh, Seunghyo Ko, Jieun Han, Chun Gown Park, Dong‐Hyun Kim, Kun Na, Wooram Park   +9 more
wiley   +1 more source

Anthracycline-induced cardiotoxicity associated with myocardial energy metabolism: mechanisms revealed through an integration of ¹⁸F-FDG PET/CT and data-independent acquisition proteomics. [PDF]

Front Cardiovasc Med
Xu Y, Chen Y, Zhang S, Zhang B, Zhu Y, Ni H, Jiang W.   +6 more
europepmc   +1 more source

IL‐2 Free Expansion of T Cells with Immunofilaments

Advanced Healthcare Materials, EarlyView.
Ratio and density of stimulatory αCD3 and αCD28 mAb on immunofilaments (IF) influence T cell expansion, cytokine production, and effector phenotype. Moreover, IL‐2 supplementation is not necessary with optimal performing IFs, which leads to simpler culture conditions, and negative side effects of IL‐2 supplementation are reduced.
Marjolein Schluck, Lea Weiss, René Classens, Carl G. Figdor, Roel Hammink   +4 more
wiley   +1 more source

Successful Chemotherapy Induction Following Management of Obstructive Jaundice and Femoral Pathological Fracture in Extensive-Stage Small Cell Lung Cancer: A Case Report. [PDF]

Respirol Case Rep
Hashimoto N, Nagai Y, Hamada Y, Uno T, Ishii R, Iemura H, Yamazaki S, Okudera K, Hamada M, Nagata M.   +9 more
europepmc   +1 more source

IMPROVING CHEMOTHERAPY DRUG DESIGN: A TIME-DEPENDENT DENSITY FUNCTIONAL THEORY STUDY OF THE BERGMAN PHOTOCYCLIZATION REACTIVITY OF ENEDIYNES

, 2014
Phillip James Marzouk
openalex   +1 more source

Smart Catheters for Diagnosis, Monitoring, and Therapy

Advanced Healthcare Materials, EarlyView.
This study presents a comprehensive review of smart catheters, an emerging class of medical devices that integrate embedded sensors, robotics, and communication systems, offering increased functionality and complexity to enable real‐time health monitoring, diagnostics, and treatment. Abstract This review explores smart catheters as an emerging class of
Azra Yaprak Tarman, Samiha Ahmed, Majed Othman Althumayri, Megan Guy, Darlenne Chavez Lugo, Frances S. Ligler, George T. Ligler, Rahmi Oklu, Hiroshi Kawahira, Michael J. McShane, Jun Kameoka, Jonathan Bova, Hatice Ceylan Koydemir   +12 more
wiley   +1 more source

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

Advanced Healthcare Materials, EarlyView.
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins, Samuel L. Hallam, Mariah J. Austin, Adrianne M. Rosales   +3 more
wiley   +1 more source

Racial and Ethnic Disparities in Persistent Chemotherapy-Induced Alopecia Among Women With Breast Cancer.

JAMA Netw Open
Kang D, Kraehenbuehl L, Lee H, Kim N, Kim JY, Park YH, Ahn HK, Goldfarb SB, Patil S, Lo Sicco KI, Shapiro J, Kearney CA, Cho J, Lacouture ME, Ahn JS.   +14 more
europepmc   +1 more source

Real-world analysis of subsequent-line strategies for EGFR C797S mutant non-small cell lung cancer patients acquired resistance to third-generation EGFR tyrosine kinase inhibitors. [PDF]

BMC Cancer
Xu J, Zhu A, Xu Y, Zhang Y, Shen Y, Niu Y, Zhong H, Zhong R.   +7 more
europepmc   +1 more source

Delivery of Multifunctional Microspheres via Intravesical Instillation for Bladder Carcinoma: Therapeutic Potential and Mechanistic Insights

Advanced Healthcare Materials, EarlyView.
PCTM microspheres were successfully synthesized using microfluidic and click chemistry techniques.In Vivo and in vitro experiments have shown that PCTM microspheres have obvious targeting, adhesion, membrane penetration and anti‐tumor properties for bladder tumors.The antitumor mechanism of PCTM microspheres is to indirectly induce S‐stage blockage of ...
Zhaoxiang Lu, Wentie Yang, Youzhi Hong, Yusen Qiao, Chaozhao Liang   +4 more
wiley   +1 more source