Results 51 to 60 of about 35,587 (239)

GIP receptor agonism blocks chemotherapy-induced nausea and vomiting

Molecular Metabolism, 2023
Objective: Nausea and vomiting remain life-threatening obstacles to successful treatment of chronic diseases, despite a cadre of available antiemetic medications.
Tito Borner, Benjamin C. Reiner, Richard C. Crist, C. Daniel Furst, Sarah A. Doebley, Julia G. Halas, Minrong Ai, Ricardo J. Samms, Bart C. De Jonghe, Matthew R. Hayes   +9 more
doaj   +1 more source

Toward Fit‐for‐Purpose Data for Drug Assessment in Non‐small Cell Lung Cancer: A Core Dataset

Clinical Pharmacology &Therapeutics, EarlyView.
Considering the high unmet medical need in people with non‐small cell lung cancer (NSCLC), the drug assessment for targeted therapies often rely on small populations and single‐arm trials, challenging the evaluation by regulatory authorities, health technology assessment bodies (HTAb), and clinicians.
Geeske F. Grit, Maaike van Dartel, Laura Rodwell, Hanneke van der Woude, Cornelis Boersma, Peter G. M. Mol, Doranne Hilarius   +6 more
wiley   +1 more source

Risk factors associated with antineoplastic chemotherapy-induced nausea and vomiting

Revista de Saúde Pública, 2020
OBJECTIVE: To estimate the incidence and to evaluate risk factors for antineoplastic nausea and vomiting with high and moderate emetogenic chemotherapy in adult patients in the first treatment cycle.
Giovana Paula Rezende Simino, Ilka Afonso Reis, Francisco de Assis Acurcio, Eli Iola Gurgel Andrade, Natalia Maria Linhares Brazil, Mariângela Leal Cherchiglia   +5 more
doaj   +2 more sources

Chemotherapy-Induced Nausea and Vomiting in Early Breast Cancer Patients Receiving Adjuvant Chemotherapy With Fluorouracil, Epirubicin, Cyclophosphamide Followed by Docetaxel Versus an Anthracycline-Free Regimen With Docetaxel, Cyclophosphamide-Results From a Randomized Clinical Trial. [PDF]

Int J Cancer
Chemotherapy‐induced nausea and vomiting (CINV) remains a significant clinical problem despite modern antiemetics. In particular, antiemetic strategies for emerging cancer therapies lack detailed evaluation. This randomized trial analyzed hourly CINV data for patients with early breast cancer who received either docetaxel plus cyclophosphamide (TC) or ...
Hörner M, Schäffler H, Häberle L, Goossens C, Pfister K, Leinert E, Veselinovic K, Brucker SY, Köhler U, Heinrich G, Schneeweiss A, Beckmann MW, Fasching PA, Janni W, Rack B, Heublein S, Ziegler P.   +16 more
europepmc   +2 more sources

Efficient Synthesis of Cannabinoid Acids

European Journal of Organic Chemistry, EarlyView.
In this study, an alternative synthesis of cannabinoid acids was developed based on an O→C acyl rearrangement. Specifically, this strategy involved regioselective bromination followed by halogen–lithium exchange and intramolecular nucleophilic addition, which led to successful carboxylation.
Ryosuke Arai, Hikari Nishiguchi, Kayo Nakamura, Hiroko Abe, Akihiko Ishida, Manabu Tokeshi, Kyohei Higashi, Akiyoshi Saitoh, Hideyo Takahashi   +8 more
wiley   +1 more source

Adherence to ESMO clinial recommendations for prophylaxis of chemotherapy-induced nausea and vomiting [PDF]

, 2011
We assessed adherence to the European Society of Medical Oncology (ESMO)/Multinational Association of Supportive Care in Cancer recommendations for prophylaxis of chemotherapy-induced nausea and vomiting (CINV) at our ...
Oliver Gautschi, Henning Burmeister, Stefan Aebi, Cristina Studer, Burmeister, H, Aebi, S, Gautschi, O, Studer, C, Martin F. Fey, Fey, M.F.   +9 more
core   +2 more sources

Treatment‐Related Adverse Events and Health‐Related Quality of Life Associated With Immune Checkpoint Inhibitor Treatment for Mucosal Head and Neck Squamous Cell Carcinoma: A Scoping Review

Head &Neck, EarlyView.
ABSTRACT Background Supportive care needs of patients receiving immune checkpoint inhibitors (ICIs) for head and neck squamous cell carcinoma (HNSCC) are ill‐defined. Hence, known treatment‐related adverse events (TRAEs) and health‐related quality of life (HRQoL) associated with ICI treatment for HNSCC were examined to inform future supportive care ...
N. D. O'Donnell, E. C. Ward, L. R. Wishart, R. Perera, C. Barrett, K. A. Edmiston, E. Mitchell, A. Pigott, R. Pitt, K. Russell, B. A. Chan, R. Ladwa   +11 more
wiley   +1 more source

D2 Receptors and Sodium Ion Channel Blockades of the Basolateral Amygdala Attenuate Lithium Chloride-Induced Conditioned Taste Aversion Applying to Cancer Chemotherapy Nausea and Vomiting

Brain Sciences, 2023
Cancer patients regularly suffer from the behavioral symptoms of chemotherapy-induced nausea and vomiting. Particularly, it is involved in Pavlovian conditioning. Lithium chloride (LiCl) was used as the unconditioned stimulus (US) and contingent with the
Zhi-Yue Gao, Chung Ming Huang, Cai-N Cheng, Andrew Chih-Wei Huang   +3 more
doaj   +1 more source

Trismus and Health‐Related Quality of Life in HNC Patients up to 10 Years Post‐Radiotherapy Completion

Head &Neck, EarlyView.
ABSTRACT Background This prospective study investigates trismus prevalence, quality of life (QOL), and trismus‐related symptoms in HNC patients up to 10 years post‐radiotherapy (RT). Methods A total of 211 patients with HNC receiving RT were followed pretreatment, 12, 60, and 120 months post‐RT.
Therese Karlsson, Lisa Tuomi, Caterina Finizia   +2 more
wiley   +1 more source

Effects of neo-adjuvant chemotherapy for oesophago-gastric cancer on neuro-muscular gastric function [PDF]

, 2012
Delayed gastric emptying symptoms are often reported after chemotherapy. This study aims to characterise the effects of chemotherapy on gastric neuro-muscular function.
Arasaradnam, Ramesh P., Jarvie, E. M., Goodyear, S. J., Borman, R. A., Snead, David R. J., Sanger, G. J., Nwokolo, Chuka U., James, Sean G., Sung, E. Z. H.   +8 more
core   +1 more source