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Chenodeoxycholic Acid: Uses and Limitations

Hospital Practice, 1979
Conclusions about the efficacy and safety of this agent for dissolving cholesterol gallstones must wait until late next year, when results of large clinical trials are available. But results from many studies are available, as are preliminary clinical data from trials of a possible alternative, ursodeoxycholic acid.
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Chenodeoxycholic Acid and Ursodeoxycholic Acid

1990
Cholelithiasis (gallstones) is a major medical and economic problem in the USA (Schoenfield, 1977; Schoenfield et al., 1981). It has been estimated to have a prevalence of 15 million women and five million men, and almost one million new cases are discovered each year (Ingelfinger, 1968; Friedman et al., 1966).
Robert A. Maxwell, Shohreh B. Eckhardt
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The Formation of Deoxycholic Acid and Chenodeoxycholic Acid in Man

Clinical Science, 1974
1. The turnover of deoxycholic acid and chenodeoxycholic acid was studied in six normolipaemic patients after oral administration of trace amounts of isotopically labelled compounds. 2. The mean values for half-life, pool size and turnover of deoxycholic acid were 3·0 days, 663 mg and 171 mg/day respectively.
K, Einarsson, K, Hellström
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Toxicity of Chenodeoxycholic Acid in the Rhesus Monkey

Gastroenterology, 1975
Chenodeoxycholic acid is an important drug for the treatment of cholesterol cholelithiasis in man. Although no toxicity has been demostrated in man, liver lesions develop in rhesus monkeys treated with chenodeoxycholic acid. To elucidate the mechanism of toxicity, chenodeoxycholic acid.
H, Dyrszka   +3 more
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Gallstone dissolution with chenodeoxycholic acid

Klinische Wochenschrift, 1980
Out of 95 patients with radiolucent gallstones who enrolled in a clinical study with chenodeoxycholic acid (CDC) for gallstone dissolution 75 patients with cholecystolithiasis completed 12 months of treatment. As a side effect 31% of patients reported intermittent diarrhea which did not cause cessation of therapy or missing of work.
H J, Weis   +2 more
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Polymorphism of chenodeoxycholic acid.

Il Farmaco; edizione scientifica, 1978
Polymorphism of chenodeoxycholic acid was studied by differential thermal analysis and X-ray diffraction. Four polymorphic forms (three crystalline and one amorphous) were characterized.
G, Giuseppetti, M, Paciotti
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