Results 61 to 70 of about 126,182 (299)

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Resection and postoperative radiation therapy for desmoid fibromatosis of the chest wall in a young woman

Surgical Case Reports, 2021
Background Surgery is an effective treatment for desmoid fibromatosis, but it may be difficult, depending on the location or local spread of the tumor, and the decision to perform surgery must be made carefully.
Daiki Noda, Miyuki Abe, Yohei Takumi, Kentaro Anami, Michiyo Miyawaki, Hideya Takeuchi, Atsushi Osoegawa, Kenji Sugio   +7 more
doaj   +1 more source

Single-breath-hold photoacoustic computed tomography of the breast [PDF]

, 2018
We have developed a single-breath-hold photoacoustic computed tomography (SBH-PACT) system to reveal detailed angiographic structures in human breasts. SBH-PACT features a deep penetration depth (4 cm in vivo) with high spatial and temporal resolutions ...
Appleton, Catherine M, Hu, Peng, Li, Lei, Lin, Li, Maslov, Konstantin, Shi, Junhui, Wang, Lihong V, Zhang, Ruiying   +7 more
core   +2 more sources

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Consumed by Abdominal Distention

Arthritis Care &Research, EarlyView.
Abimbola Fadairo‐Azinge, James Grenert, Brian Haas, Mary Margaretten   +3 more
wiley   +1 more source

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo, Ying Yu, Zhimin Zeng, Yanxin Chen, Yali Yi, Zhiqin Lu, Fujuan Zeng, Peng Xu, Daya Luo, Leifeng Chen, Anwen Liu   +10 more
wiley   +1 more source

Transcatheter arterial chemoembolization improves the resectability of malignant breast phyllodes tumor with angiosarcoma component: a case report

BMC Surgery, 2019
Background A giant phyllodes tumor of the breast is a rare fibroepithelial lesion, and its treatment is controversial. Many case reports have reported performing skin graft reconstruction after tumor excision.
Chih-Yu Kuo, Shing-Huey Lin, Kuan-Der Lee, Sho-Jen Cheng, Jan-Show Chu, Shih-Hsin Tu   +5 more
doaj   +1 more source

Chest wall reconstruction using abdominal rectus and latissimus dorsi muscle flaps: case report [PDF]

Revista Brasileira de Cirurgia Plástica, 2016
INTRODUCTION: Chest wall reconstruction remains one of the great plastic surgery repair challenges. The present work aims to report on cases of chest wall reconstruction using myocutaneous flaps after wall resection due to tumor/osteomyelitis.
Salustiano Gomes de Pinho Pessoa, Vitor de Vasconcellos Muniz, Artur de Vasconcellos Muniz, Paulo Roberto Araújo Barreto, Rafael Jorge Alves de Alcântara, Juliana Régia Furtado Matos   +5 more
doaj   +1 more source

Rethinking Perioperative Corticosteroids in Esophageal Cancer Surgery: Evidence From an Integrative Meta‐Analysis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Esophagectomy remains a highly invasive procedure associated with substantial postoperative morbidity. Pulmonary complications, anastomotic leakage, and in‐hospital mortality are of particular concern. Perioperative corticosteroids are often administered to attenuate excessive inflammatory responses; however, the clinical impact in ...
Tomohiko Yasuda, Akihisa Matsuda, Nobutoshi Hagiwara, Yoshiharu Nakamura, Hiroshi Yoshida   +4 more
wiley   +1 more source

Mesenchymal hamartoma of the liver extending through a localized chest wall defect

Journal of Pediatric Surgery Case Reports, 2018
Mesenchymal hamartoma of the liver (MHL), a common benign hepatic tumor in children, is not commonly associated with other congenital malformations. We describe a novel case of MHL extending through a localized chest wall defect.
Xiaoying Li, Weizhong Gu, Jingjing Ye
doaj   +1 more source