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Chondrosarcoma: A Clinical Review
Journal of Clinical Medicine, 2023 Chondrosarcomas are a diverse group of malignant cartilaginous matrix-producing neoplasms. Conventional chondrosarcomas are a continuum of disease based on the biologic activity of the tumor.
Aaron Gazendam +2 more
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Chondrosarcoma-from Molecular Pathology to Novel Therapies
Cancers, 2021 Simple Summary Chondrosarcoma (CHS) belongs to a broad group of sarcomas and is the second most frequent malignant bone tumor. Due to its resistance to chemo- and radiotherapy, treatment of this tumor is complicated and is mainly limited to surgery.
Anna Szumera-Cieckiewicz +2 more
exaly +2 more sources
Cell Death and Disease, 2021 Chondrosarcoma is a malignancy of soft tissue and bone that has a high propensity to metastasize to distant organs. Nerve growth factor (NGF) is critical for neuronal cell growth, apoptosis, and differentiation, and also appears to promote the ...
Huey-En Tzeng +11 more
doaj +2 more sources
Immunotherapy for Chordoma and Chondrosarcoma: Current Evidence
Cancers, 2021 Simple Summary Chordomas and chondrosarcomas are rare tumors that can occur within the skull base and spinal column and are often resistant to chemotherapy and radiation.
Tomáš Garzón-Muvdi +2 more
exaly +2 more sources
Therapeutic Targets and Emerging Treatments in Advanced Chondrosarcoma
International Journal of Molecular Sciences, 2022 Simple Summary Chondrosarcomas develop chemoresistance to standard anticancer drugs, making it difficult to control unresectable or metastatic chondrosarcomas. To improve the clinical outcomes of chondrosarcoma, new treatment approaches, such as molecule-
Katsuhiro Hayashi +2 more
exaly +2 more sources
MiRNA-based expression signatures in differential diagnosis of enchondroma and chondrosarcoma [PDF]
Journal of Bone OncologyBackground: The clinical and histological differentiation of benign enchondroma from malignant chondrosarcoma remains a major challenge. Due to their histological similarity, discrimination of enchondroma from low-grade chondrosarcoma G1/ACT particularly
Annabell Walter +11 more
doaj +2 more sources
Survival and Prognosis of Chondrosarcoma Subtypes: SEER Database Analysis
Journal of Orthopaedic Research, 2020 Chondrosarcomas are rare tumors and, historically, investigation of these tumors has been limited to small series and single‐institution studies. There have been no studies that evaluated the identification or comparison of differences in prognostic ...
Dominick Congiusta +2 more
exaly +2 more sources
Journal of Orthopaedic Surgery and Research, 2020 Objective Chondrosarcoma is the second most common primary bone sarcoma; however, unlike other tumors, the biopsy cannot easily make a definite diagnosis or predict the histological grade.
Qingyu Zhang +4 more
doaj +2 more sources
Cell Communication and Signaling, 2019 Background Chondrosarcoma is a malignant cartilaginous neoplasm of the bone which resistant to radiation therapy and chemotherapy. Cyclin-dependent kinase 4 (CKD4) is highly expressed in human cancer, and palbociclib, the inhibitor of CDK4 has been used ...
Zhengxiao Ouyang +6 more
doaj +2 more sources
Novel Therapeutic Approaches in Chondrosarcoma
Future Oncology, 2017 Chondrosarcoma is a malignant tumor of bones, characterized by the production of cartilage matrix. Due to lack of effective treatment for advanced disease, the clinical management of chondrosarcomas is exceptionally challenging.
Seth Pollack, Alex Lee, Paul H Huang
exaly +2 more sources