Results 31 to 40 of about 36,516 (242)

Gadd45β expression in chondrosarcoma: A pilot study for diagnostic and biological implications in histological grading

Diagnostic Pathology, 2010
Background Although the diagnosis of chondrosarcoma, especially the distinction between enchondroma and low-grade chondrosarcoma or low-grade chondrosarcoma and high-grade chondrosarcoma, is pathologically difficult, differential diagnosis is very ...
Ishido Yasuhiro, Yamamoto Takuya, Nagano Satoshi, Yokouchi Masahiro, Sakakima Harutoshi, Tanimoto Akihide, Zenmyo Michihisa, Komiya Setsuro, Ijiri Kosei   +8 more
doaj   +1 more source

Elevated levels of Dickkopf-1 are associated with β-catenin accumulation and poor prognosis in patients with chondrosarcoma. [PDF]

PLoS ONE, 2014
BACKGROUND: Dickkopf-1 (DKK1) is an antagonist of Wnt/β-catenin signaling implicated in tumorigenesis. However, the biological role of DKK1 and β-catenin involved in chondrosarcoma has not been sufficiently investigated.
Changbao Chen, Hua Zhou, Xiaolin Zhang, Xinlong Ma, Zhongjun Liu, Xiaoguang Liu   +5 more
doaj   +1 more source

CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression

Molecular Cancer, 2010
Background Chondrosarcoma is a disease that does not respond to conventional cytotoxic chemotherapy and expression of MMP1 is a marker for a poor prognosis. The mechanism of increased MMP1 expression in chondrosarcoma is not completely known. Our goal is
Chen Qian, Wei Lei, Sun Xiaojuan, Terek Richard M   +3 more
doaj   +1 more source

Dedifferentiated Chondrosarcoma

Definitions, 2020
The term dedifferentiated chondrosarcoma has been applied to tumors in which a well differentiated cartilaginous component, sometimes of demonstrably long duration, is associated with a less differentiated non-cartilaginous component that is assumed to ...
Andy Langdown
semanticscholar   +1 more source

Late Lung Metastasis in a Patient with a Clear Cell Chondrosarcoma: An Indication for a Life-Long Follow-Up?

Case Reports in Oncological Medicine, 2021
Background. Clear cell chondrosarcoma (CCCS) is a rare subtype of chondrosarcoma and comprises between 1.6% and 2.5% of all chondrosarcoma. They are known to be chemo- and radiotherapy resistant; surgical resection is therefore the therapy of choice ...
Paulien West, Celine Jacobs, Michael Saerens, David Creytens, Gwen Sys, Lore Lapeire   +5 more
doaj   +1 more source

Exosomal lncRNA RAMP2-AS1 Derived from Chondrosarcoma Cells Promotes Angiogenesis Through miR-2355-5p/VEGFR2 Axis

OncoTargets and Therapy, 2020
Objective Exosomes derived from cancer cells can alter the microenvironment and enhance cancer malignancy through the regulation of peripheral cell functions.
Cheng Cheng, Zhicai Zhang, Fuli Cheng, Zengwu Shao   +3 more
semanticscholar   +1 more source

The antiapoptotic gene survivin is highly expressed in human chondrosarcoma and promotes drug resistance in chondrosarcoma cells in vitro

BMC Cancer, 2011
Background Chondrosarcoma is virtually resistant to chemotherapy and radiation therapy. Survivin, the smallest member of the inhibitor of apoptosis protein family, is a critical factor for tumor progression and resistance to conventional therapeutic ...
Grifka Joachim, Tingart Markus, Balakrishnan Sanjeevi, Campean Valentina, Renkawitz Tobias, Lechler Philipp, Schaumburger Jens   +6 more
doaj   +1 more source

A screening-based approach identifies cell cycle regulators AURKA, CHK1 and PLK1 as targetable regulators of chondrosarcoma cell survival

Journal of Bone Oncology, 2019
Chondrosarcomas are malignant cartilage tumors that are relatively resistant towards conventional therapeutic approaches. Kinase inhibitors have been investigated and shown successful for several different cancer types.
Yvonne de Jong, Fairuz Bennani, Jolieke G. van Oosterwijk, Gaia Alberti, Zuzanna Baranski, Pauline Wijers-Koster, Sanne Venneker, Inge H. Briaire-de Bruijn, Brendy E. van de Akker, Hans Baelde, Anne-Marie Cleton-Jansen, Bob van de Water, Erik H.J. Danen, Judith V.M.G. Bovée   +13 more
doaj   +1 more source

Anterior chest wall resection and reconstruction due to recurrent chondrosarcoma: a case report [PDF]

Folia Medica, 2023
Chest wall chondrosarcoma is a rare malignant tumor with aggressive biological behavior. The only available treatment for primary or recurrent chondrosarcoma consists of radical surgical resection because of its well-known chemo- and radioresistance ...
Magdalena Alexieva, Georgi Yankov
doaj   +3 more sources

HGF and c-Met interaction promotes migration in human chondrosarcoma cells. [PDF]

PLoS ONE, 2013
Chondrosarcoma is a type of highly malignant tumor with a potent capacity for local invasion and causing distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs.
Hsi-Kai Tsou, Hsien-Te Chen, Ya-Huey Hung, Chia-Hao Chang, Te-Mao Li, Yi-Chin Fong, Chih-Hsin Tang   +6 more
doaj   +1 more source