Results 21 to 30 of about 20,687 (197)

Anterior chest wall resection and reconstruction due to recurrent chondrosarcoma: a case report [PDF]

Folia Medica, 2023
Chest wall chondrosarcoma is a rare malignant tumor with aggressive biological behavior. The only available treatment for primary or recurrent chondrosarcoma consists of radical surgical resection because of its well-known chemo- and radioresistance ...
Magdalena Alexieva, Georgi Yankov
doaj   +3 more sources

HGF and c-Met interaction promotes migration in human chondrosarcoma cells. [PDF]

PLoS ONE, 2013
Chondrosarcoma is a type of highly malignant tumor with a potent capacity for local invasion and causing distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs.
Hsi-Kai Tsou, Hsien-Te Chen, Ya-Huey Hung, Chia-Hao Chang, Te-Mao Li, Yi-Chin Fong, Chih-Hsin Tang   +6 more
doaj   +1 more source

Chondroid Lipoma in Left Thigh –A Rare Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2017
Chondroid lipoma is a rare variant of lipoma and often confused with chondroid tumours such as soft tissue chondroma, extraskeletal chondrosarcoma and myxoid chondrosarcoma.
Sachin Shivaji Kapse, Surekha U. Arakeri, Anita P. Javalgi   +2 more
doaj   +1 more source

Clear Cell Chondrosarcoma with Rib Cage Metastasis: Case Report

Case Reports in Oncology, 2021
Clear cell chondrosarcoma is a rare histological subtype of chondrosarcoma, usually with a relatively non-aggressive clinical course. However, infrequently they may relapse and metastasize.
Rui Caetano de Oliveira, John Reith, José Casanova   +2 more
doaj   +1 more source

Exploration of the chondrosarcoma metabolome; the mTOR pathway as an important pro-survival pathway

Journal of Bone Oncology, 2019
Background: Chondrosarcomas are malignant cartilage-producing tumors showing mutations and changes in gene expression in metabolism related genes. In this study, we aimed to explore the metabolome and identify targetable metabolic vulnerabilities in ...
Ruben D. Addie, Yvonne de Jong, Gaia Alberti, Alwine B. Kruisselbrink, Ivo Que, Hans Baelde, Judith V.M.G. Bovée   +6 more
doaj   +1 more source

Therapeutic effect of palbociclib in chondrosarcoma: implication of cyclin-dependent kinase 4 as a potential target

Cell Communication and Signaling, 2019
Background Chondrosarcoma is a malignant cartilaginous neoplasm of the bone which resistant to radiation therapy and chemotherapy. Cyclin-dependent kinase 4 (CKD4) is highly expressed in human cancer, and palbociclib, the inhibitor of CDK4 has been used ...
Zhengxiao Ouyang, Sisi Wang, Ming Zeng, Zhihong Li, Qing Zhang, Wanchun Wang, Tang Liu   +6 more
doaj   +1 more source

Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity

Scientific Reports, 2017
Chondrosarcoma is a malignant primary bone tumor. Sirtuin-1 (SIRT1), which is a member of sirtuin family, plays a dual role either in cancer promotion or suppression.
Sung-Chuan Chao, Ying-Ju Chen, Kuo-How Huang, Kuan-Lin Kuo, Ting-Hua Yang, Kuo-Yuan Huang, Ching-Chia Wang, Chih-Hsin Tang, Rong-Sen Yang, Shing-Hwa Liu   +9 more
doaj   +1 more source

Lymph node metastasis in extremity chondrosarcomas

South Asian Journal of Cancer, 2020
Bacground: Primary bone sarcomas mainly metastasize through haematogenous route and rarely through lymph nodes due to paucity of lymphatic channels in the bone (1).
Vineet Kurisunkal, Ashish Gulia, Puri Ajay, Bharat Rekhi   +3 more
doaj   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

Dedifferentiated chondrsarcoma: a clinicopathologic analysis of 25 cases

BMC Musculoskeletal Disorders, 2021
Background To investigate the clinical, imaging and pathological features of dedifferentiated chondrosarcoma for better diagnosis. Methods Patients who had been confirmed to have dedifferentiated chondrosarcoma were enrolled in this study and analyzed in
Lei Cao, Yuan Wu, Shu-Man Han, Tao Sun, Bao-Hai Yu, Feng Gao, Wen-Juan Wu, Bu-Lang Gao   +7 more
doaj   +1 more source