Results 41 to 50 of about 35,110 (238)

Osteoblastoma in the occipital bone: A case report of a rare tumor in the calvarium [PDF]

, 2020
Osteoblastomas infrequently occur in the calvarium, displaying a preference for temporal and frontal bones when it does. We present an unusual case of a large, expansile osteoblastoma in the occipital bone of a 23-year-old man who presented with a ...
Faro, Scott H., Gorniak, Richard J., Trunz, Lukas M.   +2 more
core   +2 more sources

Exploration of the chondrosarcoma metabolome; the mTOR pathway as an important pro-survival pathway

Journal of Bone Oncology, 2019
Background: Chondrosarcomas are malignant cartilage-producing tumors showing mutations and changes in gene expression in metabolism related genes. In this study, we aimed to explore the metabolome and identify targetable metabolic vulnerabilities in ...
Ruben D. Addie, Yvonne de Jong, Gaia Alberti, Alwine B. Kruisselbrink, Ivo Que, Hans Baelde, Judith V.M.G. Bovée   +6 more
doaj   +1 more source

Therapeutic effect of palbociclib in chondrosarcoma: implication of cyclin-dependent kinase 4 as a potential target

Cell Communication and Signaling, 2019
Background Chondrosarcoma is a malignant cartilaginous neoplasm of the bone which resistant to radiation therapy and chemotherapy. Cyclin-dependent kinase 4 (CKD4) is highly expressed in human cancer, and palbociclib, the inhibitor of CDK4 has been used ...
Zhengxiao Ouyang, Sisi Wang, Ming Zeng, Zhihong Li, Qing Zhang, Wanchun Wang, Tang Liu   +6 more
doaj   +1 more source

Lymph node metastasis in extremity chondrosarcomas

South Asian Journal of Cancer, 2020
Bacground: Primary bone sarcomas mainly metastasize through haematogenous route and rarely through lymph nodes due to paucity of lymphatic channels in the bone (1).
Vineet Kurisunkal, Ashish Gulia, Puri Ajay, Bharat Rekhi   +3 more
doaj   +1 more source

Chordoma. Clinical characteristics, management and prognosis of a case series of 25 patients [PDF]

, 2010
Background: Adequate surgery still remains the only curative treatment of chordoma. Interesting clinical data on advanced disease with molecularly targeted therapies were reported.Methods: We described the clinical outcome of a series of chordoma ...
Virginia Ferraresi, Carmen Nuzzo, Carmine Zoccali, Ferdinando Marandino, Antonello Vidiri, Nicola Salducca, Massimo Zeuli, Diana Giannarelli, Francesco Cognetti, Roberto Biagini, A Jemal, R Chugh, CE Peña, JM Mirra, NL Higinbotham, C Catton, PW Chambers, S Boriani, F Tzortzidis, D Baratti, D Schulz-Ertner, DC Weber, GF Fleming, E Tamborini, S Stacchiotti, H Hof, K Schönegger, ZL Gokaslan, HY Zhang, P Bergh, KL Foweraker, PA Forsyth, BJ Cummings, P Gabriele, GC Feigl, HD Suit, M Austin-Seymour, M Austin-Seymour, G Noël, R Chugh, PG Scimeca, A Azzarelli, PG Casali, PG Casali, PM Weinberger, S Stacchiotti   +45 more
core   +1 more source

Insurance impacts survival for children, adolescents, and young adults with bone and soft tissue sarcomas. [PDF]

, 2020
BackgroundWhile racial/ethnic survival disparities have been described in pediatric oncology, the impact of income has not been extensively explored. We analyzed how public insurance influences 5-year overall survival (OS) in young patients with sarcomas.
Goldsby, Robert E, Murphy, Patricia, Penumarthy, Neela L, Shiboski, Stephen C, Winestone, Lena E, Wustrack, Rosanna   +5 more
core   +1 more source

Mesenchymal Chondrosarcoma [PDF]

International Journal of Particle Therapy, 2016
To review the treatment and outcomes of patients with mesenchymal chondrosarcomas (MC).Review of the pertinent literature.MC is a rare aggressive small round blue cell malignancy that may arise in either bone or soft tissue. It usually presents in the 2nd or 3rd decade of life and exhibits an approximately equal gender predilection.
William M, Mendenhall, John D, Reith, Mark T, Scarborough, Bruce K, Stechmiller, Nancy P, Mendenhall   +4 more
openaire   +2 more sources

Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity

Scientific Reports, 2017
Chondrosarcoma is a malignant primary bone tumor. Sirtuin-1 (SIRT1), which is a member of sirtuin family, plays a dual role either in cancer promotion or suppression.
Sung-Chuan Chao, Ying-Ju Chen, Kuo-How Huang, Kuan-Lin Kuo, Ting-Hua Yang, Kuo-Yuan Huang, Ching-Chia Wang, Chih-Hsin Tang, Rong-Sen Yang, Shing-Hwa Liu   +9 more
doaj   +1 more source

Dedifferentiated chondrsarcoma: a clinicopathologic analysis of 25 cases

BMC Musculoskeletal Disorders, 2021
Background To investigate the clinical, imaging and pathological features of dedifferentiated chondrosarcoma for better diagnosis. Methods Patients who had been confirmed to have dedifferentiated chondrosarcoma were enrolled in this study and analyzed in
Lei Cao, Yuan Wu, Shu-Man Han, Tao Sun, Bao-Hai Yu, Feng Gao, Wen-Juan Wu, Bu-Lang Gao   +7 more
doaj   +1 more source

Multi-modality management of chondrosarcoma of scapula: A case report and review of literature

Cancer Treatment and Research Communications, 2023
Chondrosarcoma are malignant tumours in which neoplastic cells produce cartilage. The most commonly affected sites are pelvis, femur, humerus and ribs. Scapula involvement is relatively rare.
Ramakant Tiwari, Bharti Devnani, Balamurugan Thirunavukkarasu, Puneet Pareek, Prateek Daga, Amit Kumar   +5 more
doaj   +1 more source