Results 41 to 50 of about 36,516 (242)

Chondroid Lipoma in Left Thigh –A Rare Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2017
Chondroid lipoma is a rare variant of lipoma and often confused with chondroid tumours such as soft tissue chondroma, extraskeletal chondrosarcoma and myxoid chondrosarcoma.
Sachin Shivaji Kapse, Surekha U. Arakeri, Anita P. Javalgi   +2 more
doaj   +1 more source

Beyond the Influence of IDH Mutations: Exploring Epigenetic Vulnerabilities in Chondrosarcoma

Cancers, 2020
Simple Summary Cartilage tumors frequently harbor mutations in the isocitrate dehydrogenase (IDH1 or IDH2) genes. These mutations cause an increase in the levels of the oncometabolite D-2-hydroxyglutarate (D-2-HG), which leads to widespread changes in ...
S. Venneker, A. Kruisselbrink, Z. Baranski, Ieva Palubeckaitė, I. B. Briaire-de Bruijn, J. Oosting, P. French, E. Danen, J. Bovée   +8 more
semanticscholar   +1 more source

Exploration of the chondrosarcoma metabolome; the mTOR pathway as an important pro-survival pathway

Journal of Bone Oncology, 2019
Background: Chondrosarcomas are malignant cartilage-producing tumors showing mutations and changes in gene expression in metabolism related genes. In this study, we aimed to explore the metabolome and identify targetable metabolic vulnerabilities in ...
Ruben D. Addie, Yvonne de Jong, Gaia Alberti, Alwine B. Kruisselbrink, Ivo Que, Hans Baelde, Judith V.M.G. Bovée   +6 more
doaj   +1 more source

Clear Cell Chondrosarcoma with Rib Cage Metastasis: Case Report

Case Reports in Oncology, 2021
Clear cell chondrosarcoma is a rare histological subtype of chondrosarcoma, usually with a relatively non-aggressive clinical course. However, infrequently they may relapse and metastasize.
Rui Caetano de Oliveira, John Reith, José Casanova   +2 more
doaj   +1 more source

Lymph node metastasis in extremity chondrosarcomas

South Asian Journal of Cancer, 2020
Bacground: Primary bone sarcomas mainly metastasize through haematogenous route and rarely through lymph nodes due to paucity of lymphatic channels in the bone (1).
Vineet Kurisunkal, Ashish Gulia, Puri Ajay, Bharat Rekhi   +3 more
doaj   +1 more source

Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity

Scientific Reports, 2017
Chondrosarcoma is a malignant primary bone tumor. Sirtuin-1 (SIRT1), which is a member of sirtuin family, plays a dual role either in cancer promotion or suppression.
Sung-Chuan Chao, Ying-Ju Chen, Kuo-How Huang, Kuan-Lin Kuo, Ting-Hua Yang, Kuo-Yuan Huang, Ching-Chia Wang, Chih-Hsin Tang, Rong-Sen Yang, Shing-Hwa Liu   +9 more
doaj   +1 more source

Dedifferentiated chondrsarcoma: a clinicopathologic analysis of 25 cases

BMC Musculoskeletal Disorders, 2021
Background To investigate the clinical, imaging and pathological features of dedifferentiated chondrosarcoma for better diagnosis. Methods Patients who had been confirmed to have dedifferentiated chondrosarcoma were enrolled in this study and analyzed in
Lei Cao, Yuan Wu, Shu-Man Han, Tao Sun, Bao-Hai Yu, Feng Gao, Wen-Juan Wu, Bu-Lang Gao   +7 more
doaj   +1 more source

Translocase of the outer mitochondrial membrane complex subunit 20 (TOMM20) facilitates cancer aggressiveness and therapeutic resistance in chondrosarcoma

Biochimica et Biophysica Acta - Molecular Basis of Disease, 2020
Chondrosarcoma is the second most common primary bone malignancy, representing one fourth of all primary bone sarcomas. It is typically resistant to radiation and chemotherapy treatments.
Megan E Roche, Zhao Lin, D. Whitaker-Menezes, Tingting Zhan, K. Szuhai, J. Bovée, J. Abraham, Wei-Wei Jiang, U. Martinez-Outschoorn, Atrayee Basu-Mallick   +9 more
semanticscholar   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

Genomic profiling identifies association of IDH1/IDH2 mutation with longer relapse free and metastasis free survival in high-grade chondrosarcoma

Clinical Cancer Research, 2019
Purpose: Chondrosarcomas are the second most common primary malignant bone tumors. Although histologic grade is the most important factor predicting the clinical outcome of chondrosarcoma, it is subject to interobserver variability.
G. Zhu, K. Nafa, N. Agaram, A. Zehir, R. Benayed, Justyna Sadowska, L. Borsu, C. Kelly, W. Tap, N. Fabbri, E. Athanasian, P. Boland, J. Healey, M. Berger, M. Ladanyi, M. Hameed   +15 more
semanticscholar   +1 more source