Results 61 to 70 of about 20,687 (197)

Magnetic Resonance Imaging Features of Intravascular Osteosarcoma Affecting the Ventral Internal Vertebral Venous Plexus Causing Cervical Myelopathy in a Dog

Veterinary Radiology &Ultrasound, Volume 67, Issue 4, July 2026.
ABSTRACT A 10.5‐year‐old male castrated Standard Poodle was referred for the evaluation of chronic C6–T2 myelopathy. MRI revealed a severe asymmetric enlargement of the ventral internal vertebral venous plexus, intervertebral/vertebral veins, and possibly the C6 basivertebral vein, with secondary mild spinal cord compression.
Robert Wise, Rachel Durrwachter, Nathan Fanzone, Wilfried Mai   +3 more
wiley   +1 more source

BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors

BMC Cancer, 2012
Background As major regulators of normal chondrogenesis, the bone morphogenic protein (BMP) and transforming growth factor β (TGFB) signaling pathways may be involved in the development and progression of central chondrosarcoma. In order to uncover their
Boeuf Stephane, Bovée Judith VMG, Lehner Burkhard, van den Akker Brendy, van Ruler Maayke, Cleton-Jansen Anne-Marie, Richter Wiltrud   +6 more
doaj   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, Volume 13, Issue 35, 24 June 2026.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Concomitant Medication Effects on Immunotherapy Outcomes in Sarcoma: A Pooled Post Hoc Analysis of Seven Phase II Trials

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Concomitant medications (CMs) influence outcomes in patients receiving immune checkpoint inhibitors (ICIs), but their impact in sarcoma remains undefined. We assessed the association between CM use and ICI outcomes in patients with advanced or metastatic sarcoma. Methods This pooled analysis included patients from seven investigator‐
Adel Shahnam, Kristen DiConza, Simran Jasnani, Rhoena Desir‐Camille, Evan Rosenbaum, Olayode Babatunde, Ciara M. Kelly, Lauren B. Banks, Viswatej Avutu, Ping Chi, Sujana Movva, Mark A. Dickson, Mrinal M. Gounder, Mary L. Keohan, Robert G. Maki, William D. Tap, Sandra P. D'Angelo   +16 more
wiley   +1 more source

Integrative genomic and functional characterization of ADAMTS3 reveals its inflammatory regulation via NF‐κB and STAT3 pathways in osteosarcoma

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Abstract Osteosarcoma (OS) is an aggressive bone malignancy characterized by genomic instability and extensive extracellular matrix (ECM) remodeling. Members of the ADAMTS family are matrix‐associated proteases implicated in tumorigenesis; however, their roles in OS remain poorly defined. This study provides a comprehensive genomic, transcriptomic, and
Ehed Muhammed Aymaz, Meltem Alper, Feyza Nur Sav, Tuğşen Aydemir, Feray Köçkar   +4 more
wiley   +1 more source

β5 integrin up-regulation in brain-derived neurotrophic factor promotes cell motility in human chondrosarcoma.

PLoS ONE, 2013
Chondrosarcoma is a primary malignant bone cancer, with a potent capacity to invade locally and cause distant metastasis; it has a poor prognosis and shows a predilection for metastasis to the lungs.
Chih-Yang Lin, Hui-Jye Chen, Te-Mao Li, Yi-Chin Fong, Shan-Chi Liu, Po-Chun Chen, Chih-Hsin Tang   +6 more
doaj   +1 more source

Systemic Treatment of Advanced Chordoma With Molecular Targeted Therapies: A Large Multicentre European Retrospective Case Series

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background This retrospective series reports outcomes and prognostic factors for advanced chordoma (AC) treatment with molecular targeted therapies (MTTs) in different treatment lines. Methods This is a retrospective series of 57 patients with AC treated between 2004 and 2023 at one of seven participating sarcoma centres.
Astrid Lipplaa, Nadia Hindi, Pawel Teterycz, Robin J. Young, Ioannis Boukonavis, Josefina Cruz, Javier Martinez‐Trufero, Frank Speetjens, Wilco Peul, Robert J. P. van der Wal, Hans Gelderblom   +10 more
wiley   +1 more source

Asymptomatic Chondrosarcoma of the Skull base: A Case Report

Ear, Nose & Throat Journal
Chondrosarcoma of the skull base is a malignant tumor of cartilage origin. Clinical manifestations are nonspecific, early can be asymptomatic. We report a case of asymptomatic chondrosarcoma of the skull base which is difficult to confirm the diagnosis ...
Jie Yu MD, Yang Zhao MD, Xu Tian MD, Zhiqiang Gao MD, Guodong Feng MD   +4 more
doaj   +1 more source

Extracellular Vesicles as Drivers of Lung Endothelial Dysfunction in ARDS: Mechanisms and Therapeutic Opportunities

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
This review summarizes how extracellular vesicles from diverse pulmonary and extrapulmonary sources contribute to endothelial dysfunction in ARDS and evaluates emerging endothelial‐targeted therapies for their potential to mitigate EV‐mediated pathogenic mechanisms.
Mohammed Yaman Al Matni, Patrick Belvitch, Steven M. Dudek, Eleftheria Letsiou   +3 more
wiley   +1 more source

Chondrosarcoma of a rib

International Journal of Surgery Case Reports, 2015
Chondrosarcoma of a rib is a very rare malignant tumor of the bone. Most patients were present with an enlarging painful anterior chest wall tumor. We present a case of an asymptomatic 29-years old female with a tumor size of 10cm×12cm on the left anterior chest wall involving the 8th rib.
Sangma, Mima Maychet B., Dasiah, Simon
openaire   +2 more sources