Results 51 to 60 of about 602,886 (284)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The determination of the resistance inheritance against common bunt in wheat and half-diallel hybrids

Plant Protection Science, 2019
This study was conducted to determine the inheritance of common bunt resistance in twelve bread wheat varieties and their half-diallel hybrids in Turkey. The disease ratings were performed on the F2 generations of the hybrids in field conditions.
Gülçİn Akgören Palabiyik, İsmail Poyraz, Ahmet Umay   +2 more
doaj   +1 more source

Tests for Independence in Two-Way Contingency Tables with Small Samples [PDF]

, 2008
When testing the null hypothesis of independence in a two-way contingency table, the likelihood ratio test statistic is approximately distributed as Chi-squared d for large sample sizes (N) but may not be for small samples.
Sharp, Stephen
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

An Asymptotic Two-Sided Test in a Family of Multivariate Distribution

Journal of Statistical Theory and Applications (JSTA), 2020
In the present paper, a two-sided test in a family of multivariate distribution according to the Mahalanobis distance with mean vector and positive definite matrix is considered.
Abouzar Bazyari, Mahmoud Afshari, Monjed H. Samuh   +2 more
doaj   +1 more source

Human factor analysis of general accidents in coal mines based on HFACS

Meikuang Anquan, 2021
In order to find out the human factors leading to coal mine general accidents, the paper counts the coal mine accidents occurred in 2019. Based on the investigation reports, HFACS is used to carry out the statistics and analysis of 43 coal mine general ...
BAI Yanlong, LI Haili, CHEN Yu, HE Shulei, BAI Changjiang, XI Long, XUE Yubi, PENG Jiajia, WANG Xin
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

A Socioecological Assessment of Vulture Abundance and Community Perceptions Before and After Landfill Site Shift in Pokhara, Nepal

Ecology and Evolution
South Asia is home to nine species of vultures, and Nepal hosts all of them. Remarkably, all these species have also been recorded in Pokhara. This could be attributed to Pokhara's location along bird migration pathways and the year‐round availability of
Binita Timilsina, Mohan Bucha Magar, Sangam Poudel, Dinesh Bhusal, Dipa Gurung, Ankit Bilash Joshi, Yajna Prasad Timilsina   +6 more
doaj   +1 more source

HARDY-WEINBERG EQUILIBRIUM ASSUMPTIONS IN CASE-CONTROL TESTS OF GENETIC ASSOCIATION [PDF]

, 2009
The case-control study design is commonly used in genetic association study with a binary trait using unrelated individuals from a population. To test association with a binary trait in a case-control or cohort study, the standard analysis is a chi ...
Lee, Myoungkeun
core