Results 41 to 50 of about 3,636,957 (301)
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Impact of COVID-19 Pandemic, Social Vulnerability, and Opioid Overdoses in Chicago
AJPM Focus, 2023 Introduction: This research was undertaken to examine the individual and neighborhood drivers that contributed to increases in opioid overdose deaths during the COVID-19 pandemic.
Randall W. Knoebel, PharmD, MPH +1 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Reconsidering Hilberseimer’s Chicago
Urban Planning, 2020 The German architect and urbanist Ludwig Hilberseimer spent the second half of his career as an internationally influential urbanist, author, and educator while living and working in Chicago.
Philip Denny, Charles Waldheim
doaj +1 more source
Clinical variations of polypoidal choroidal vasculopathy: A cohort study from Japan and the USA
Scientific Reports, 2023 We describe the clinical characteristics of treatment-naïve polypoidal choroidal vasculopathy (PCV) in three tertiary clinic settings in 2 cities (Chicago in the USA and Nishinomiya in Japan).
Hisashi Fukuyama +5 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Sucho, občas akcie — černý pátek na newyorské burze očima Čechů v USA [PDF]
Historie - Otázky - ProblémyThe text explores the views of the Czech immigrant community in the US on the 1929 New York Stock Exchange crash through Czech newspapers from Chicago, Nebraska, and Texas, using a comparative approach to analyse the publications.
Michael Durčák
doaj
Humanimalia, 2016 Dave Aftandilian, and Gavin Van Horn, eds. City Creatures: Animal Encounters in the Chicago Wilderness. Chicago and London: The University of Chicago Press, 2015. xi+377 pp. $30.00 hb; $18.00 e-book.
Katharine Mershon
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source