Results 61 to 70 of about 821,382 (263)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Chicago Exploration Days [PDF]
Microscopy and Microanalysis, 2011 Extended abstract of a paper presented at Microscopy and Microanalysis 2011 in Nashville, Tennessee, USA, August 7–August 11, 2011.
openaire +4 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
International Journal of COPD, 2022 Matthew Bonomo,1,* Michael G Hermsen,1,* Samuel Kaskovich,1 Maximilian J Hemmrich,1 Juan C Rojas,2 Kyle A Carey,3 Laura Ruth Venable,4 Matthew M Churpek,5 Valerie G Press3,6 1Pritzker School of Medicine, University of Chicago, Chicago, IL, USA ...
Bonomo M +8 more
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The Famous Women Dinner Service: In Conversation with Contemporary Art
British Art Studies, 2017 This conversation between Judy Chicago, The Women’s Art League, and Hana Leaper, filmed by Jonathan Law at the Elizabeth A. Sackler Center for Feminist Art, Brooklyn Museum, will be published in early 2018.
Judy Chicago +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Variation of iStent Procedure Rates by State in Response to the COVID-19 Pandemic
Clinical Ophthalmology, 2022 Kelly Vogel,1 Cole N Rojas,1 Angelo P Tanna,1 Dustin D French1– 4 1Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; 2Department of Medical Social Science, Northwestern University Feinberg School of ...
Vogel K, Rojas CN, Tanna AP, French DD
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