Results 81 to 90 of about 5,196,912 (292)
Background Doublecortin and calcium/calmodulin-dependent protein kinase-like-1 (DCAMKL1) is a candidate marker for progenitor cells in the gastrointestinal mucosa.
Watanabe Hiromitsu +5 more
doaj +1 more source
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Persistent H. pylori infection triggers the repair program of the mucosa, such as spasmolytic polypeptide‐expressing metaplasia (SPEM). However, the mechanism underlying the initiation of SPEM in gastric tissues by H. pylori remains unclear.
Lijiao He +14 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Other title: Title from HTML header (viewed May 24, 2011): Office of Chief Medical Examiner
Updated irregularly; Began in 2002?; Title from home page (publisher's Web site, viewed May 24, 2011).; At head of title: State of Connecticut.; Harvested from the web on 10/3/12Official website of the Office of the Chief Medical Examiner.
core +1 more source
GROSS AND MICROSCOPIC STRUCTURE OF THE CAROTID BODY IN THE ROCKY PIGEON (COLUMBA LIVIA).
Topographically, the carotid body in rocky pigeon has a silvery-white in in colour and showed different localization. It located on or in the vicinity of the carotid and lateral to the caudal thyroid arteries.
N. S. Al-Samarrae +2 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Brunaini Khoza is a friend of the Chief Fofoza Mwamitwa and composed this song in his honour, here sung by the chief himself. The gist of the song is that without the Chief the people are likely to be in considerable distress which only his presence can ...
Mwamitwa, Fofoza (Chief) +2 more
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