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A booster regime of liposome-delivered live-attenuated CHIKV vaccine RNA genome protects against chikungunya virus disease in mice [PDF]

Vaccine, 2023
Mosquito-transmitted chikungunya virus (CHIKV) is the causal pathogen of CHIKV disease and is responsible for global epidemics of arthritic disease. CHIKV infection can lead to severe chronic and debilitating arthralgia, significantly impacting patient ...
Abeyratne, E, Yang, C, Liu, X, Shambhavi Rao, Ali Zaid, Helen Mostafavi, Zaid, A, Rao, S, Freitas, JR, Tharmarajah, K, Kothila Tharmarajah, Adam Taylor, Mehfuz Zaman, Xiang Liu, Mostafavi, H, Suresh Mahalingam, Zaman, M, Joseph R. Freitas, Eranga Abeyratne, Mahalingam, S, Chenying Yang, Taylor, A   +21 more
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Chikungunya Virus (Chikv): General Characteristics and Possible Impact on Hemotherapy

La Prensa Medica, 2015
Chikungunya Virus (Chikv): General Characteristics and Possible Impact on Hemotherapy Chikungunya virus (CHIKV) is an arbovirus belonging to the Alphavirus genus of the Togaviridae family. The virus is transmitted by Aedes mosquitos, the most important of which are A. aegypti and A. albopictus.
Svetoslav Nanev Slavov, Katia Kaori Otaguiri   +1 more
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Seroprevalence of Chikungunya Virus (CHIKV) Infection on Lamu Island, Kenya, October 2004

The American Journal of Tropical Medicine and Hygiene, 2008
An outbreak of Chikungunya virus (CHIKV) disease associated with high fever and severe protracted arthralgias was detected in Lamu, Kenya, peaking in July 2004. At least 1,300 cases were documented. We conducted a seroprevalence study to define the magnitude of transmission on Lamu Island. We conducted a systematic cross-sectional survey.
Kibet, Sergon, Charles, Njuguna, Rosalia, Kalani, Victor, Ofula, Clayton, Onyango, Limbaso S, Konongoi, Sheryl, Bedno, Heather, Burke, Athman M, Dumilla, Joseph, Konde, M Kariuki, Njenga, Rosemary, Sang, Robert F, Breiman   +12 more
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Chikungunya Virus (CHIKV): Coming to America

Biosafety, 2014
Chikungunya Virus (CHIKV) is an arbovirus of the alphavirus genus (Togaviridae family) transmitted by the bite of infected Aedes mosquitoes. The word, Chikungunya, translates to “that which bends up”, based on the stooped position of patients during the rheumatic symptoms of the disease.
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Magnetic Resonance Imaging Brain Findings in Chikungunya Virus (CHIKV) Infection with Neurological Complication during Epidemic Outbreak

Neurology India, 2023
Background and Objective: The Chikungunya virus is an alphavirus RNA of the family Togaviridae transmitted by the Aedes mosquito. We aim to report magnetic resonance imaging (MRI) brain findings for neurological complications at our institute during epidemic outbreak. Materials and Methods:
Kanika Sekhri, Sethi, Abhay Kumar, Aryan, Prem Kumar, Ganeshan   +2 more
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A Child with Serious Chikungunya Virus (CHIKV) Infection Requiring Intensive Care, After an Outbreak

The Indian Journal of Pediatrics, 2010
A 5 1/2-yr-old boy presented with high grade fever for 4 days, and cervical adenitis, body ache, arthralgia, followed by sudden onset of breathlessness. He had clinical, electrocardiographic and echo evidence of myocarditis and congestive cardiac failure.
P Ramesh, Menon, Krishnan, C, Jayaram, Sankar, K M, Gopinathan, Girija, Mohan   +4 more
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Nanotechnology: A promising approach of antiviral treatments against chikungunya virus (CHIKV)

Journal of Scientific and Innovative Research, 2018
Following its emergence in Africa, spread to the Indian Ocean islands in 2006, and occurrences in regions of the world where it hadn’t been reported in the past, Chikungunya has become an emerging public health concern in many countries. The past outbreaks of the chikungunya virus (CHIKV) have caused widespread morbidity and mortality.
Rishikesh Kumar, Ganesh C Sahoo, null Bhawna, Aparna Ramachandran, Md. Yousuf Ansari, Krishna Pandey, VNR Das, RK Topno, Major Madhukar, Pradeep Das   +9 more
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Chikungunya Virus (CHIKV): The Novel Challenge to the Healthcare System

Pakistan Journal of Medical & Health Sciences
Chikungunya (CHIKV) is a viral illness transmitted by mosquitoes, characterized by fever and intense arthralgia. It is induced by a ribonucleic acid (RNA) virus classified within the alphavirus genus of the Togaviridae family1. The word “chikungunya” originates from a phrase in the Kimakonde phrases of southern the Republic of Tanzania, indicating “to ...
Pir eh, Iffat Jamal, Syed Zulfiqar Ali Shah, Muqadas Fatima, Farheen Qadeer, Mushahid Ali   +5 more
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Vathasura Kudineer, an Andrographis based polyherbal formulation exhibits immunomodulation and inhibits chikungunya virus (CHIKV) under in vitro conditions

Journal of Ethnopharmacology, 2023
Chikungunya disease (CHIKD) is caused by the alphavirus, chikungunya virus (CHIKV) and is characterized by acute fever and joint inflammation; the inflammation continues even after clearance of the virus from the system, persisting for several months to years. Currently, there are no modern medicines/vaccines available for its treatment and use of over-
Abdul Hasan, Shree Devi MS, Geetika Sharma, Vimal Narayanan, P. Sathiyarajeswaran, S. Vinayak, Sujatha Sunil   +6 more
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Diagnosing the Outbreak and Spread of the Chikungunya Virus in Central & South America - The DARPA CHIKV Challenge

Journal of Clinical and Biomedical Advances, 2023
In 2014, the U.S. Defense Advanced Research Projects Agency (DARPA) issued a “challenge” to forecast the future outbreaks and spreads of the virus Chikungunya Virus (CHIKV) in Central and South America. We took on the challenge of predicting the cumulative number of Pacific Atlantic Health Organization (PAHO) reported Chikungunya or CHIKV cases by ...
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