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Origin, evolution, and phylogeography of recent epidemic CHIKV strains

Infection, Genetics and Evolution, 2012
Chikungunya virus (CHIKV) is an arthropod-borne virus of the Alphavirus genus, which is transmitted to humans by Aedes spp. mosquitoes and was firstly identified in Tanzania in the mid 1950s. In this article, the findings of a phylogenetic and phylogeographic analysis of the recent CHIKV pandemic are reported.
Alessandra Lo Presti, Massimo Galli, Gianguglielmo Zehender   +2 more
exaly   +3 more sources

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Conjugates of ibuprofen inhibit CHIKV infection and inflammation

Molecular Diversity, 2023
Chikungunya virus infection has become a global health concern because of its high rates of morbidity and mortality in patients with preexisting conditions. Inflammation and arthritis are the major symptoms of CHIKV that persist even after clearance of CHIKV.
Rudra N, Dash, Mamidi, Prabhudutta, Saikat, De, Ranjit P, Swain, Alok K, Moharana, Bharat B, Subudhi, Soma, Chattopadhyay   +6 more
openaire   +2 more sources

Nonreciprocity in CHIKV and MAYV Vaccine-Elicited Protection

Vaccines
Chikungunya virus (CHIKV) is a pathogenic arthritogenic alphavirus responsible for large-scale human epidemics for which a vaccine was recently approved for use. Mayaro virus (MAYV) is a related emerging alphavirus with epidemic potential with circulation overlap potential with CHIKV.
Igor P Dmitriev, John M Powers, Whitney C Weber   +2 more
exaly   +5 more sources

Development of Proniosome Gel Formulation for CHIKV Infection

Pharmaceutics
Given the increasing aging population and the rising prevalence of musculoskeletal diseases due to obesity and injury, urgent research is needed to formulate new treatment alternatives, as current options remain inadequate. Viruses can exacerbate arthritis and worsen symptoms in patients with pre-existing osteoarthritis.
Ayça Altay Benetti, Fok-Moon Lum, Ahmad Suhaimi   +2 more
exaly   +4 more sources

A review targeting the infection by CHIKV using computational and experimental approaches

Journal of Biomolecular Structure and Dynamics, 2021
The rise of normal body temperature of 98.6 °F beyond 100.4 °F in humans indicates fever due to some illness or infection. Viral infections caused by different viruses are one of the major causes of fever. One of such viruses is, Chikungunya virus (CHIKV) is known to cause Chikungunya fever (CHIKF) which is transmitted to humans through the mosquitoes,
Durgesh, Kumar, Kamlesh, Kumari, Ramesh, Chandra, Pallavi, Jain, Lata, Vodwal, Geetu, Gambhir, Prashant, Singh   +6 more
openaire   +2 more sources

Development of a Specific CHIKV-E2 Monoclonal Antibody for Chikungunya Diagnosis [PDF]

Virologica Sinica, 2019
Chikungunya fever is a vector-borne viral disease transmitted to humans by chikungunya virus (CHIKV)-infected mosquitoes. There have been many outbreaks of CHIKV infection worldwide, and the virus poses ongoing risks to global health. To prevent and control CHIKV infection, it is important to improve the current CHIKV diagnostic approaches to allow for
Jihyun Yang, Haryoung Poo, Young Bong Kim   +2 more
exaly   +3 more sources

An overview of the immune response and Arginase I on CHIKV immunopathogenesis

Microbial Pathogenesis, 2019
Chikungunya virus (CHIKV) is mosquito-borne alphavirus that has caused epidemics around the world. Many individuals affected by the disease may experience joint pain that persists for months after the acute phase. The pathophysiology of viral arthritis is not completely elucidated.
Ana Paula Lombardi Pereira, Helena Tiemi Suzukawa, Aline Miquelin do Nascimento, Aedra Carla Bufalo Kawassaki, Camila Regina Basso, Dayane Priscila dos Santos, Kamila Falchetti Damasco, Laís Fernanda Machado, Marla Karine Amarante, Maria Angelica Ehara Watanabe   +9 more
openaire   +2 more sources

Blunting CHIKV infection by keeping T cells in check

Science Translational Medicine, 2017
Modulating the host immune response ameliorates arthritic disease in mice infected with chikungunya virus (Miner et al . and Teo et al .).
Gasque, Philippe, Jaffar-Bandjee, Marie-Christine   +1 more
openaire   +3 more sources

Chikungunya Virus (CHIKV): Coming to America

Biosafety, 2014
Chikungunya Virus (CHIKV) is an arbovirus of the alphavirus genus (Togaviridae family) transmitted by the bite of infected Aedes mosquitoes. The word, Chikungunya, translates to “that which bends up”, based on the stooped position of patients during the rheumatic symptoms of the disease.
openaire   +1 more source

Chicungnya, CHIKV, Chikungunya o Chicunguña

2016
El aula de clase, la investigacion y el momento que vive Colombia con una enfermedad denominada Chicunguna o Chicungunya fueron las grandes herramientas para conocer en que consiste y por que los pacientes se sienten desprotegidos, desesperados, sin respuesta a una enfermedad por la cual solamente reciben como medicamento acetaminofen y muchas ...
Amparo Aurora Ramírez-Tamayo, Juan Luciano Olivella-Jacquín   +1 more
openaire   +1 more source