Results 121 to 130 of about 301,041 (307)

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Teacher-child relationship quality for young children with parent reported language concerns

, 2008
Previous research has demonstrated the importance of the qualities of the teacher-child relationship on children’s development. Close teacher-child relationships are especially important for children at risk.
Hand, Kirstine Alicia
core  

Parent-child communication and educational anxiety: a longitudinal analysis based on the common fate model

BMC Psychology
Background In the face of family stress and emerging family problems, the transactional model of stress and coping provides new perspectives for solving stress problems in the family.
Fengqiang Gao, Chunze Xu, Qing Lv, Yufei Zhao, Lei Han   +4 more
doaj   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Division of child care, parenting roles, and parent-child relationship quality in same-sex headed families [PDF]

, 2017
This study examined division of child care, parenting roles, and parent-child relationship quality, both within and across same-sex couples. Analyses were carried out both at the individual level and at the couple level.
Auber, Valerie W., NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

'Beyond Anti-Smacking': Rethinking parent-child relations

, 2006
Recently, it has been argued that ‘anti-smacking’ campaigns have been so successful that ‘explicit pro-smackers’ are now thin on the ground. Yet the use of physical chastisement remains widespread.
Anderson, Simon, Brownlie, Julie
core   +1 more source

eQTL Meta‐Analysis Reveals Conserved and Population‐Specific Regulatory Variation Underlying Nutritional Trait Evolution and Domestication in Tomato

Advanced Science, EarlyView.
A comprehensive meta‐analysis of expression quantitative trait loci (eQTLs) across five diverse tomato populations reveals a high‐resolution atlas of transcriptional regulation and uncovers conserved and population‐specific regulatory architectures underlying fruit nutritional quality traits, including flavonoids, sugars, organic acids, carotenoids ...
Jiantao Zhao, Xin Wang, Jing Zhang, Ryan McQuinn, Je Min Lee, Itay Gonda, Ari Feder, Yimin Xu, Baike Wang, Qinghui Yu, Denise M. Tieman, Sanwen Huang, Harry Klee, James J. Giovannoni, Zhangjun Fei   +14 more
wiley   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Children’s contact services: key issues [PDF]

, 2015
Children’s Contact Services (CCSs) are designed to provide a safe, supervised environment for children to spend time with the parent they do not live with, or to facilitate the transfer of children from one parent to another, in circumstances where ...
Cathryn Hunter, Joanne Commerford
core  

Parent–child conflict and adolescent health literacy in Mexico: Results from a nationwide dyad study in Mexico

Global Public Health
Research suggests that health literacy (HL) is critical in preventing and managing health problems. However, over half of adults in Mexico report having inadequate health literacy. Research suggests the parent–child relationship can be a key predictor of
Steven Hoffman, Alyssa Black, Kaitlin Ward, Anna Bennion, David Wood, Flavio F. Marsiglia   +5 more
doaj   +1 more source