Results 71 to 80 of about 1,992,173 (360)

Maternal and child reflective functioning in the context of child sexual abuse: pathways to depression and externalising difficulties

European Journal of Psychotraumatology, 2016
Background Sexual abuse is a well-recognised risk factor for child psychopathology. Little is known regarding whether child and maternal mentalization can be considered a potential resource or protective factor in this context, respectively, mediating or
K. Ensink, Michaël Bégin, L. Normandin, P. Fonagy   +3 more
semanticscholar   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li, Xiaochen Zhang, Jiangwei Xia, Shuang Liu, Yushan Du, Sihan Li, Shukui Zhang, Yong Zhang, Fen Ji, Jianwei Jiao, Jingjing Zhang   +10 more
wiley   +1 more source

Child Abuse Syndrome

Journal of Education, Health and Sport, 2017
According to WHO, child abuse is defined as "any intentional or unintended action towards a person under the age of 18 that negatively affects the present or future health, experience, physical and psychosocial development of a child".
Monka Turska, Michał Raban, Cezary Grochowski, Beata Kulik-Rechberger   +3 more
doaj   +3 more sources

Parents' perceptions about child abuse and their impact on physical and emotional child abuse: A study from primary health care centers in Riyadh, Saudi Arabia

Journal of Family and Community Medicine, 2017
OBJECTIVE: To determine perceptions of parents about child abuse, and their impact on physical and emotional child abuse. MATERIALS AND METHODS: Two hundred parents attending three primary health care centers (PHCCs) in Riyadh serving National Guard ...
Mohammed N Al Dosari, Mazen Ferwana, Imad Abdulmajeed, Khaled K Aldossari, Jamaan M Al-Zahrani   +4 more
doaj   +1 more source

The Need for a Prevention Program for Child Sexual Abuse in Brazil: A Report of Shortfall Care to Pedophilia and its Critical Consequences [PDF]

, 2023
Furian, Gabriel, Beier, Klaus Michael, Schwarz, Karine, da Silva, Dhiordan Cardoso, Grundmann, Dorit, Lobato, Maria Inês Rodrigues   +5 more
openalex   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

The Current situation of Child and adolescent psychological problems and intervention in China

Asian Journal of Medical Sciences, 2016
In China, the psychological health problems of children and adolescents have been more and more serious recently. The psychological disorders not only have a lot of adverse effects for children and adolescents, but also were an important source of mental
Wenyan Jiao
doaj   +1 more source

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

The non-linear impacts of poverty, economic growth and unemployment on child abuse

Discover Social Science and Health
Child abuse remains a persistent and grave issue worldwide, with significant social and economic implications. In Malaysia, despite various measures, child abuse rates have shown a concerning upward trend.
Mohd Shahidan Shaari, Mujeeb Saif Mohsen Al Absey, Temitayo B. Majekodunmi, Amri Sulong, Muhammad Baqir Abdullah, Abdul Rahim Ridzuan, K. P. Jaheer Mukthar   +6 more
doaj   +1 more source