Results 91 to 100 of about 3,099,799 (302)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
DEMAND FOR CHILD CARE AND FEMALE EMPLOYMENT IN COLOMBIA [PDF]
Due to the increase in labor force attachment of mothers of young children in the last decade, child care policies have a renewed importance. This paper uses Colombian data to perform a characterization of the child care market, generating stylized facts
Amanda Glassman, Ximena Pena-Parga
core
Residential child care qualifications audit 2007 [PDF]
, 2007 In recent years there has been a drive to develop a fully qualified residential child care sector in Scotland. In 2003 the Scottish Social Services Council (SSSC) announced the baseline qualifications for residential child care staff and set down a ...
Anderson, Maureen +4 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
First Class in Learning -- First Class in Life: How Washington's Early Childhood Education Career and Wage Ladder Delivers First-Class Care [PDF]
, 2010 High-quality early learning cannot be achieved or sustained when the bonds between teacher and child are broken because teachers leave their jobs to gain higher paid employment in order to support their own families.
Gary Burris, Hannah Lidman, John Burbank
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Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Child Care and the Employment Behavior of Single and Married Mothers [PDF]
This paper examines the relationship between the cost of child care and the employment behavior of married and single mothers. The data used in this paper are from the 1987 SIPP, the first SIPP panel to utilize an improved probing of child care usage and
Jean Kimmel
core +1 more source
Child Care Expenses Make Middle-Class Incomes Hard to Reach [PDF]
, 2018 In this brief, authors Robert Paul Hartley, Marybeth Mattingly, and Christopher Wimer present estimates of the number of families that cannot maintain a middle-class income as a result of child care expenses.
Hartley, Robert Paul +2 more
core +1 more source