Results 101 to 110 of about 3,099,799 (302)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Risk factors for maternal near-miss in an undeveloped province in south-central China, 2012–2022
BMC Public HealthObjective To explore the risk factors for maternal near-miss (MNM) using the WHO near-miss approach. Methods Data were obtained from the Maternal Near-Miss Surveillance System in Hunan Province, China, 2012–2022. Multivariate logistic regression analysis
Xu Zhou +6 more
doaj +1 more source
Intergenerational Child Care Support and the Fluctuating Fertility: A Note [PDF]
This paper describes the relation between fertility and intergenerational child-care support provided by grandparents in a model based on the overlapping generations model with endogenous fertility.
Kenji Azetsu +2 more
core
Who cares for the sick kids? parents’ access to paid time to care for a sick child [PDF]
, 2012 This brief analyzes employed parents’ access to five or more paid sick days annually to care for a sick child in 2008. Using data from the 2008 National Study of the Changing Workforce collected by the Families and Work Institute (the most recent data ...
Schaefer, Andrew P., Smith, Kristin
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
BMC Public HealthObjective To explore risk factors for birth defects (including a broad range of specific defects). Methods Data were derived from the Population-based Birth Defects Surveillance System in Hunan Province, China, 2014–2020.
Xu Zhou +6 more
doaj +1 more source
Mothers’ Everyday Realities and Child Placement Experiences (SUMMARY REPORT) [PDF]
, 2003 Placing a child in substitute care is one of the most challenging aspects of child welfare work. In situations of apprehension, child welfare workers may be required to make quick decisions about child placement sometimes with very limited information ...
Freymond, Nancy Colleen
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Determinants of Child Care Participation [PDF]
When estimating the determinants of child care participation, the simultaneity in mothers' decision to work and in the decision to use child care is a major challenge. In this study, we provide evidence on the determinants of institutional child care use
Coneus, Katja +2 more
core +3 more sources