Results 101 to 110 of about 18,495,960 (408)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Child Development

, 2018
The history and purpose of the Nellis Air Force Base Child Care Center is to provide a safe learning environment for developing children of military families.https://digitalscholarship.unlv.edu/educ_sys_202/1039/thumbnail ...
Harris, Theresa
core  

State CCDBG Plans to Promote Opportunities for Babies & Toddlers in Child Care [PDF]

, 2009
Reviews states' 2008-09 plans for using Child Care and Development Block Grant funds to help low-income families access child care. Cites examples aligned with CLASP's recommendations for ensuring environments that support healthy growth and ...
Rachel Schumacher, Teresa Lim
core  

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

Integrating nutrition and child development interventions: scientific basis, evidence of impact, and implementation considerations.

Advances in Nutrition, 2015
The Millennium Development Goals (MDGs) have contributed to unprecedented reductions in poverty and improvement in the lives of millions of men, women, and children in low- and middle-income countries.
M. Black, R. Pérez‐Escamilla, Sylvia Fernandez Rao   +2 more
semanticscholar   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Oxytocin for male subjects with autism spectrum disorder and comorbid intellectual disabilities: A randomized pilot study

Frontiers in Psychiatry, 2016
Approximately half of autism spectrum disorder (ASD) individual suffer from comorbid intellectual disabilities (ID). Oxytocin (OXT) receptors are highly expressed in temporal lobe structures and are likely to play a modulatory role in excitatory ...
Toshio eMunesue, Hiroyuki eNakamura, Mitsuru eKikuchi, Yui eMiura, Noriyuki eTakeuchi, Tokie eAnme, Eiji eNanba, Kaori eAdachi, Kiyotaka eTsubouchi, Yoshimichi eSai, Kenichi eMiyamoto, Shinichi eHorike, Shigeru eYokoyama, Hideo eNakatani, Hirotaka eKosaka, Yoshio eMinabe, Haruhiro eHigashida   +16 more
doaj   +1 more source

Emotion regulation as a scientific construct: methodological challenges and directions for child development research.

Child Development, 2004
Emotion regulation has emerged as a popular topic, but there is doubt about its viability as a scientific construct. This article identifies conceptual and methodological challenges in this area of study and describes exemplar studies that provide a ...
P. Cole, Sarah E. Martin, Tracy A. Dennis   +2 more
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Chemicals, nutrition, and autism spectrum disorder: a mini-review

Frontiers in Neuroscience, 2016
The rapid increase of the prevalence of autism spectrum disorder (ASD) suggests that exposure to chemicals may impact the development of ASD. Therefore, we reviewed literature on the following chemicals, nutrient to investigate their association with ASD:
Takeo eFujiwara, Naho eMorisaki, Yukiko eHonda, Makiko eSampei, Yukako eTani, Yukako eTani   +5 more
doaj   +1 more source