Results 121 to 130 of about 1,509,749 (267)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

COVID-19 rise in Bangladesh correlates with increasing detection of B.1.351 variant

BMJ Global Health, 2021
Samir K Saha, Mohammod Shahidullah, Mohammad Shahidul Islam, Yogesh Hooda, Arif M Tanmoy, Mohammad Saiful Islam Sajib, Senjuti Saha, Afroza Akter Tanni, Sharmistha Goswami, Syed Muktadir Al Sium, Roly Malaker, Shuborno Islam, Hafizur Rahman, Ataul Mustufa Anik, Nikkon Sarker, Kinkar Ghosh, Probir Kumar Sarkar, Mohammed Rizwanul Ahsan Bipul, Syed Shafi Ahmed   +18 more
doaj   +1 more source

Northern Territory maternal and child health collection 1988

, 1988
This report on Perinatal and Infant Mortality identified by maternal race (Aboriginal or non-Aboriginal) is based on the data prepared for the 18th Northern Territory Maternal and Child Health Committee Meeting held on 18 May 1989 to review data based on
Statistical Services, Durling, Gypsy
core  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Design and implementation of edutainment-based school intervention to improve knowledge of acute rheumatic fever and rheumatic heart disease among school-going children in Nepal

Discover Public Health
Background Rheumatic heart disease (RHD), a preventable yet life-threatening condition, remains a major public health concern in Nepal, particularly among children.
Sandeepa Karki, Shishir Paudel, Dhurba Khatri, Rudra Prakash Hada, Yamuna Chhetri, Bhagawan Koirala   +5 more
doaj   +1 more source

Use of personal child health records in the UK: findings from the millennium cohort study.

, 2006
OBJECTIVES: The personal child health record (PCHR) is a record of a child's growth, development, and uptake of preventive health services, designed to enhance communication between parents and health professionals.
Bedford, H, Millennium Cohort Study Child Health Group, Walton, S, Dezateux, C   +3 more
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Health insurance and child support [PDF]

The child support system has been increasing its efforts to make health insurance a part of child support awards. Data from the 1990 Current Population Survey Child Support Supplement show that 40 percent of child support awards require that the ...
D. R. Meyer
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source