Results 101 to 110 of about 1,509,749 (267)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Parental Health and Child Schooling [PDF]
Evidence on the role of parental health on child schooling is surprisingly thin. We explore this issue by estimating the short-run effects of parents\' illness on child school enrollment.
Mariapia Mendola, Massimiliano Bratti
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Scientific ReportsFever and diarrhea are key causes of malnutrition, growth and development disorders, and death among children. At present, most studies on the associated factors of fever and diarrhea in children are concentrated in African and South Asian countries, but
Huixia Li +8 more
doaj +1 more source
Early Child Public Health Home Visiting Annotated Bibliography
, 2008 National Collaborating Centre for Determinants of Health. (2008). Early child public health home visiting annotated bibliography. Antigonish, NS: National Collaborating Centre for Determinants of Health, St. Francis Xavier University.
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Franklin-Naismith Lesion: A Severe Variant of Hip Pointer
Orthopaedic Journal of Sports Medicine, 2019 Sinem Gultekin BBiomed Sci, +1 more
doaj +1 more source
Child Health CheckPoint Rationale document
, 2019 The Child Health CheckPoint Rationale document describes the source of each measure, it's rationale for inclusion in CheckPoint, how it was administered and scored, and any modifications from the original measure or previous LSAC ...
Child Health CheckPoint Team (4820070)
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