Results 91 to 100 of about 1,509,749 (267)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Prenatal diagnosis and follow-up of a child with mosaic tetrasomy 9p without obvious abnormal clinical manifestations

Molecular Cytogenetics
Introduction To report the prenatal diagnosis and follow-up of a fetus with mosaic tetrasomy 9p without obvious abnormal clinical manifestations. Case report A fetus diagnosed with mosaic T9p at Shaoxing Maternal and Child Health Hospital in February ...
Lifang Zhang, Feiyan Qian, Weiping Chen, Jiaming Fan, Yan Zeng, Tingting Luo, Ming Che, Bin Yu, Tao Zhang   +8 more
doaj   +1 more source

Promoting child and family social and emotional wellbeing, and constipation and encopresis

, 2013
The foundations of good social and emotional development are formed in early infant-parent and caregiver relationships (Centre for Community Child Health, 2009).
Centre for Community Child Health
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Statistical tables for 1990 Northern Territory Maternal & Child Health Committee : data gathered

, 1991
Northern Territory Maternal & Child Health committee Meeting 1990 statistical ...
Woods, Maxene, Durling, Gypsy
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

New waves, new variants, old inequity: a continuing COVID-19 crisis

BMJ Global Health, 2021
Samir K Saha, Mohammad Shahidul Islam, Yogesh Hooda, Senjuti Saha, Sudipta Saha, Afroza Akter Tanni, Sharmistha Goswami, Syed Muktadir Al Sium, Shuborno Islam, Hafizur Rahman, Ataul Mustufa Anik, Arif Mohammad Tanmoy, Apurba Rajib Malaker, Md Saidul Haq, Tasnim Jabin, Md Mobarok Hossain, Nazifa Tabassum, Md Jibon Hossain   +17 more
doaj   +1 more source

South African Child Gauge 2009/2010

, 2010
The South African Child Gauge is produced annually by the Children's Institute, University of Cape Town to monitor government and civil society's progress towards realising the rights of children.This issue focuses on child health and is divided into ...
Pendlebury, Shirley, Smith, Charmaine, Pendlebury, P, Smith, C, Lake, Lori, Lake, L, Kibel, M, Kibel, Maurice   +7 more
core  

Unhealthy Consequences: Energy Costs and Child Health

, 2007
Substantial and compelling medical and public health evidence indicated that non-medical factors, such as home energy costs, profoundly influence child health and well-being. Child Health Impact Assessment offered an evidence- and experience-based method
JoHanna Flacks, Child Health Impact Working Group (CHIWG)   +1 more
core   +1 more source