Results 81 to 90 of about 1,509,749 (267)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Clinical experience of the expanded carrier screening for recessive genetic diseases in a large cohort study in Southern central China

Scientific Reports
Recessive monogenic disorders represent a significant cause of congenital malformations and disabilities in pediatric populations. The present study aims to provide the first comprehensive assessment of clinical experience with expanded carrier screening
Lu pan, Haiyan Luo, Tingting Huang, Huizhen Yuan, Yongyi Zou, Qing Lu, Baitao Zeng, Pengpeng Ma, Yan Yang, Ting Huang, Danping Liu, Bicheng Yang, Yanqiu Liu, Jun Zou, Fen Fu   +14 more
doaj   +1 more source

The National Road Map Strategic Plan to Accelerate Reduction of Maternal,Newborn and Child Deaths in Tanzania 2008-2015 [PDF]

, 2008
This document has been conceived for various purposes. The health of the mother is closely linked to the health and survival of the child. In addition, the socio-economic\ud level of the mother and the maternal health status (HIV/AIDS, malaria, nutrition)
Ministry of Health and Social Welfare, (MoHSW)
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Improving child and family health services for families most in need and building positive relationships with families

, 2012
While most families of young children are well supported socially and make good use of services, some do not. Children from families that have poor social supports and that make limited or no use of early child and family services are at increased risk ...
Centre for Community Child Health
core  

Child Health CheckPoint Material Disclaimer

, 2019
This document describes the disclaimers relating to the Child Health CheckPoint datasets and related ...
Child Health CheckPoint Team (4820070)
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Novel inflammatory markers for predicting adverse pregnancy outcomes in pregnant women with polycystic ovary syndrome: a retrospective case‒control study

BMC Pregnancy and Childbirth
Objective To investigate the potential predictive value of novel inflammatory markers for adverse pregnancy outcomes in pregnant women with polycystic ovary syndrome (PCOS). Methods A retrospective case‒control study was conducted.
Na Pan, Jing Zhang, Ning Zhu, Mengting Liu, Shuying Yang, Zhanshuai Song, Haibo Song   +6 more
doaj   +1 more source

Travelling with children, and nutrition and mental health

, 2014
Transport accidents are a cause of death and disability across the developed world. In Australia, transport accidents are a leading cause of child deaths from unintentional injury (ABS, 2006) and a leading cause of hospitalisation (ABS, 2007).
Centre for Community Child Health
core  

Child Health

, 2002
The largest global equity gap in health, is among children, and concentrated in communicable diseases. This note examines the work of the Integrated Management of Childhood Illness (IMCI) - a strategy to
World Bank
core   +1 more source